TRADD Antibody
Source Reactivity Background References- Product Name
- TRADD Antibody
- Chemical Name
- TRADD Antibody
- Synonyms
- TRADD Antibody;Mouse Monoclonal TRADD Antibody
- CBNumber
- CB35701905
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb11504
- Product name
- TRADD antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $402.9
- Updated
- 2021/12/16
- Product number
- orb11504
- Product name
- TRADD antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $654.5
- Updated
- 2021/12/16
TRADD Antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
Apoptosis mediated by death factors like FasL and TNF-α involves the formation of a death-inducing signaling complex to their respective receptors. Upon ligand activation to their receptors, Fas and TNF-R1 associate with death domain containing adaptor proteins FADD and TRADD. In addition to its carboxy-terminal DD, FADD contains an amino-terminal death effector domain that binds to DEDs found on caspase-8 which leads to activation of this initiator caspase. Caspase-8 subsequently activates downstream effector caspases, like caspase-3, resulting in the cleavage of proteins involved in the execution of apoptosis. Unlike FADD, TRADD does not contain a DED. Apoptosis driven by TNF-R1 binding to TRADD involves association of TRADD and FADD which then leads to activation of caspase-8.
References
[1] Nagata, S. (1997) Cell 88, 355-65.
[2] Chinnaiyan, A.M. et al. (1995) Cell 81, 505-12.
[3] Boldin, M.P. et al. (1995) J. Biol. Chem. 270, 7795-8.
[4] Hsu, H. et al. (1995) Cell 81, 495-504.
[5] Muzio, M. et al. (1996) Cell 85, 817-27.
[6] Boldin, M.P. et al. (1996) Cell 85, 803-15.
[7] Hsu, H. et al. (1996) Cell 84, 299-308.
TRADD Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
TRADD Antibody Suppliers
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- 15921930842 15921930842
- yh-wang@univ-bio.com
- Country
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- Tel
- 65-64153170
- Sales.China@bio-rad.com
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- Enzo Biochem Inc. 13797054060
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