TRPV4 antibody
Source Reactivity Background References- Product Name
- TRPV4 antibody
- Chemical Name
- TRPV4 antibody
- Synonyms
- TRPV4 antibody
- CBNumber
- CB35702609
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb163273
- Product name
- TRPV4 antibody
- Purity
- Affinity-purified by affinity-chromatography using epitope-specific immunogen.
- Packaging
- 100μg
- Price
- $280.5
- Updated
- 2021/12/16
- Product number
- orb2457
- Product name
- TRPV4 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $402.9
- Updated
- 2021/12/16
- Product number
- orb165910
- Product name
- TRPV4 antibody
- Purity
- Peptide Affinity purified
- Packaging
- 400μl
- Price
- $525.3
- Updated
- 2021/12/16
- Product number
- orb2457
- Product name
- TRPV4 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $654.5
- Updated
- 2021/12/16
- Product number
- orb85971
- Product name
- TRPV4 antibody
- Purity
- Immunoaffinity purified
- Packaging
- 50μg
- Price
- $725.9
- Updated
- 2021/12/16
TRPV4 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Monkey
Background
TRPV4 is a member of the transient receptor potential vanilloid family of ion channels, and functions as a Ca2+-permeant non-selective cation channel. TRPV4 channels are expressed in many cell types, with particular abundance in sensory and spinal neurons. TRPV4 channels play a role in maintaining cellular homeostasis, by facilitating transmembrane Ca2+ transport in response to various stimuli, including thermal stress, fatty acid metabolites, and hypotonicity. Mutations in the TRPV4 gene have consequently been attributed to a variety of pathological conditions. For example, constitutively active TRPV4 mutants can lead to excess Ca2+ influx, resulting in toxicity and degeneration of peripheral nerves. TRPV4-dependent Ca2+ influx was also shown to mediate strain-induced and TGFβ1-induced epithelial-mesenchymal transition, suggesting a mechanistic role for TRPV4-mediated Ca2+ transport in fibrosis and oncogenesis. Consistent with this, studies in capillary endothelial cells showed that mechanical strain-induced Ca2+ influx through TRPV4 promote focal adhesion and stress fiber remodeling, mediated specifically through integrins, PI3K, and downstream kinases including Rho and ROCK.
References
[1] Everaerts, W. et al. (2010) Prog Biophys Mol Biol 103, 2-17.
[2] Vriens, J. et al. (2004) Proc Natl Acad Sci U S A 101, 396-401.
[3] Fecto, F. et al. (2011) J Biol Chem 286, 17281-91.
[4] Sharma, S. et al. (2019) J Cell Mol Med 23, 761-74.
[5] Thodeti, C.K. et al. (2009) Circ Res 104, 1123-30.
TRPV4 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
TRPV4 antibody Suppliers
- Tel
- 15921930842 15921930842
- yh-wang@univ-bio.com
- Country
- China
- ProdList
- 25004
- Advantage
- 58
- Tel
- 18007124176 19384116026
- 2706668885@qq.com
- Country
- China
- ProdList
- 4987
- Advantage
- 58
- Tel
- 400821347
- orders@novusbio.com
- Country
- China
- ProdList
- 6434
- Advantage
- 58
- Tel
- 027-87196173
- cusabio@163.com
- Country
- China
- ProdList
- 6066
- Advantage
- 58
- Tel
- 027-19371278702 18008634902
- 19384116026@163.com
- Country
- China
- ProdList
- 3008
- Advantage
- 58
- Tel
- 0755-26755892 1-949-553-1900
- international@genetex.com
- Country
- China
- ProdList
- 6092
- Advantage
- 58
- Tel
- 858.663.9055 8586639055
- NSJBioname@qq.com
- Country
- China
- ProdList
- 6941
- Advantage
- 58
- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
- Country
- China
- ProdList
- 6174
- Advantage
- 58
- Tel
- 18886812933
- sales@biosynth.com
- Country
- China
- ProdList
- 6218
- Advantage
- 58
- Tel
- 21-80243558 86218024
- info@cellsignal.cn
- Country
- China
- ProdList
- 6427
- Advantage
- 58