5-CHLORO-2-FLUOROPHENYLBORONIC ACID
- Product Name
- 5-CHLORO-2-FLUOROPHENYLBORONIC ACID
- CAS No.
- 352535-83-2
- Chemical Name
- 5-CHLORO-2-FLUOROPHENYLBORONIC ACID
- Synonyms
- 57842;AKOS BRN-0727;5-chloro-2-fluorophenylboric acid;5-Chloro-2-fluorophenylbornic acid;(5-chloro-2-fluorophenyl)boronicaci;5-CHLORO-2-FLUOROPHENYLBORONIC ACID;5-CHLORO-2-FLUOROBENZENEBORONIC ACID;5-Chloro-2-fluorobenzeneboronicacid97%;B-(5-Chloro-2-fluorophenyl)boronic acid;5-Chloro-2-fluorobenzeneboronic acid 97%
- CBNumber
- CB3663716
- Molecular Formula
- C6H5BClFO2
- Formula Weight
- 174.37
- MOL File
- 352535-83-2.mol
5-CHLORO-2-FLUOROPHENYLBORONIC ACID Property
- Melting point:
- 122-127 °C (lit.)
- Boiling point:
- 310.8±52.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 7.35±0.58(Predicted)
- color
- White to Almost white
- InChI
- 1S/C6H5BClFO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,10-11H
- InChIKey
- GGTUVWGMCFXUAS-UHFFFAOYSA-N
- SMILES
- OB(O)c1cc(Cl)ccc1F
- CAS DataBase Reference
- 352535-83-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2645
- Product name
- 5-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $58
- Updated
- 2025/07/31
- Product number
- C584623
- Product name
- 5-Chloro-2-fluorophenylboronic acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC41843
- Product name
- 5-Chloro-2-fluorophenylboronic acid
- Packaging
- 10g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- C2202
- Product name
- 5-Chloro-2-fluorophenylboronic acid
- Purity
- 96%
- Packaging
- 25g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 035639
- Product name
- 5-Chloro-2-fluorophenylboronic acid
- Packaging
- 5g
- Price
- $61
- Updated
- 2021/12/16
5-CHLORO-2-FLUOROPHENYLBORONIC ACID Chemical Properties,Usage,Production
Uses
suzuki reaction
Uses
Reactant involved in:
- Suzuki cross-coupling reactions
- Synthesis of biaryl amides with muscarinic acetylcholine receptor subtype M1 agonistic activity
- Synthesis of kinesin spindle protein inhibitors
- GABA α2/3 agonist preparation
Synthesis
To a solution of 2-bromo-4-chloro-1-fluorobenzene (5 g, 0.0238 mol) in anhydrous ether (30 ) at -70??C under nitrogen atmosphere was added a 2M solution of n-BuLi in hexane (13 mL, 0.0262 mol). mL) in anhydrous ether (30 ) was added to a 2 M solution of n-BuLi in hexane (13 mL, 0.0262 mol). The solution was stirred at the same temperature for 30 min and then triisopropyl borate (4.93 g,0.0262 mol) was added dropwise to the solution. The white slurry formed was stirred at -70 ??C for 30 min and then warmed to room temperature and stirred for 1 h. The reaction was monitored by TLC and H NMR to monitor the reaction. After the reaction was completed, the reaction mixture was hydrolyzed with 6N NaOH and stirred for 1 h. The reaction mixture was extracted with EtOAc. The organic layer was washed with brine and concentrated under reduced pressure to obtain a viscous compound, which was ground with n-pentane and dried to obtain 5-chloro-2-fluorophenylboronic acid as an off-white solid.
5-CHLORO-2-FLUOROPHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CHLORO-2-FLUOROPHENYLBORONIC ACID manufacturers
- Product
- 5-CHLORO-2-FLUOROPHENYLBORONIC ACID 352535-83-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-05
- Product
- 5-CHLORO-2-FLUOROPHENYLBORONIC ACID 352535-83-2
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 5-CHLORO-2-FLUOROPHENYLBORONIC ACID 352535-83-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10