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4-Chloro-2-fluorophenylboronic acid

Product Name
4-Chloro-2-fluorophenylboronic acid
CAS No.
160591-91-3
Chemical Name
4-Chloro-2-fluorophenylboronic acid
Synonyms
AKOS BRN-0717;1-Borono-4-chloro-2-fluorobenzene;4-CHLORO-2-FLUOROPHENYLBORONIC ACID;4-chloro-2-fluorobenzenboronic acid;2-fluoro-4-chlorophenylboronic acid;4-CHLORO-2-FLUOROBENZENEBORONIC ACID;4-Chloro-2-fluorobenzeneboronicacid98%;4-Chloro-2-fluorophenylboronic acid，98%;B-(4-chloro-2-fluorophenyl)-Boronic acid;4-Chloro-2-fluorobenzeneboronic acid 98%
CBNumber
CB0271596
Molecular Formula
C6H5BClFO2
Formula Weight
174.37
MOL File
160591-91-3.mol
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4-Chloro-2-fluorophenylboronic acid Property

Melting point:
248-250
Boiling point:
289.2±50.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
8.19±0.58(Predicted)
color 
White to Light yellow
Water Solubility 
Insoluble in water.
InChI
InChI=1S/C6H5BClFO2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,10-11H
InChIKey
YBNDRTRLXPEWKQ-UHFFFAOYSA-N
SMILES
B(C1=CC=C(Cl)C=C1F)(O)O
CAS DataBase Reference
160591-91-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36
Safety Statements 
26-36/37/39-37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BML00162
Product name
4-Chloro-2-fluorophenylboronic acid
Purity
Aldrich
Packaging
1g
Price
$42.8
Updated
2025/07/31
TCI Chemical
Product number
C3048
Product name
4-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
C3048
Product name
4-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$82
Updated
2025/07/31
TRC
Product number
C584620
Product name
4-Chloro-2-fluorophenylboronic acid
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
C584620
Product name
4-Chloro-2-fluorophenylboronic acid
Packaging
500mg
Price
$65
Updated
2021/12/16
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4-Chloro-2-fluorophenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

Used as intermediates for pharmaceutical and agrochemicals.

Uses

suzuki reaction

Synthesis

121-43-7

1996-29-8

7732-18-5

160591-91-3

To a 2L round bottom flask was added 1-bromo-4-chloro-2-fluorobenzene (50 g, 238.7 mmol) and anhydrous tetrahydrofuran (900 ml), and the mixture was cooled to -78°C with stirring. Slowly n-butyllithium (2.5 M hexane solution, 100 ml, 250 mmol) was added dropwise and stirred continuously for 1 hour at this temperature. Subsequently, trimethyl borate (31.9 ml, 286 mmol) was added slowly and the reaction was continued for 30 minutes. After completion of the reaction, 1N aqueous hydrochloric acid solution (600 ml) was added and gradually warmed up to room temperature while stirring. The organic layer was separated, dried with anhydrous magnesium sulfate and filtered. The solvent was removed by distillation under reduced pressure, and the concentrated product was extracted with a mixture of chloroform and hexane solvents, and finally purified by recrystallization to afford 4-chloro-2-fluorophenylboronic acid (33.7 g, 193.3 mmol) in 81% yield.

References

[1] Patent: KR101680413, 2016, B1. Location in patent: Paragraph 0129-0132

4-Chloro-2-fluorophenylboronic acid Preparation Products And Raw materials

Raw materials

4-Chloro-2-fluoroaniline Trimethyl borate Sodium bromide Sodium chloride Sodium sulfite Sodium nitrite Hydrogen bromide Tetrahydrofuran Diethyl ether Ethyl acetate Cuprous bromide Hydrochloric acid Copper(II) sulfate Triisopropyl borate Magnesium sulfate PETROLEUM ETHER n-Butyllithium

Preparation Products

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4-Chloro-2-fluorophenylboronic acid Suppliers

Americas 1 China 188 Europe 1 Germany 6 India 3 Japan 1 Russia 1 United Kingdom 8 United States 31 Global 240
Zhengzhou HQ Material Co., Ltd.
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0371-67759225 13526468238
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sale@hqmat.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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market03@meryer.com
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China
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INTATRADE GmbH
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+49 3493/605464
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+49 3493/605470
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sales@intatrade.de
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Germany
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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saleschina@alfa-asia.com
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China
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Energy Chemical
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sales8178@energy-chemical.com
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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sales@chemwish.com
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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Beijing Ouhe Technology Co., Ltd
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010-010-82967028 13522913783
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+86-10-82967029
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2355560935@qq.com
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China
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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+86-21-54098501
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+86-21-54096319
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sales@sinch.com.cn
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China
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View Lastest Price from 4-Chloro-2-fluorophenylboronic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-Chloro-2-fluorophenylboronic acid 160591-91-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-13
Hebei Xinsheng New Material Technology Co., LTD.
Product
4-Chloro-2-fluorophenylboronic acid 160591-91-3
Price
US $35.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 Ton
Release date
2023-10-27
Hebei Xinsheng New Material Technology Co., LTD.
Product
4-Chloro-2-fluorophenylboronic acid 160591-91-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
30000 Kg
Release date
2023-11-28

160591-91-3, 4-Chloro-2-fluorophenylboronic acidRelated Search:

4-Chlorophenylboronic acid Florfenicol 4-Fluorobenzeneboronic acid Phenylboronic acid MCPA SODIUM Transfluthrin 2,3,4,5,6-PENTAFLUOROBENZENEBORONIC ACID 3-(Benzyloxy)-2-chloro-6-fluorophenylboronic acid,3-Benzyloxy-2-chloro-6-fluorophenylboronic acid Difluorochloromethane 6-Bromo-3-chloro-2-fluorophenylboronic acid 5-CHLORO-2-FLUOROPHENYLBORONIC ACID 3-CHLORO-5-FLUOROPHENYLBORONIC ACID 2-CHLORO-6-FLUOROPHENYLBORONIC ACID 3-CHLORO-4-FLUOROPHENYLBORONIC ACID,3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) 2-FLUOROPHENYLBORONIC ACID 2-CHLORO-4-FLUOROPHENYLBORONIC ACID 2-CHLORO-5-FLUOROPHENYLBORONIC ACID 4-CHLORO-2,6-DIFLUOROPHENYLBORONIC ACID

  • AKOS BRN-0717
  • 4-CHLORO-2-FLUOROPHENYLBORONIC ACID
  • 4-CHLORO-2-FLUOROBENZENEBORONIC ACID
  • 4-Chloro-2-fluorobenzeneboronic acid 98%
  • 4-Chloro-2-fluorobenzeneboronicacid98%
  • 4-chloro-2-fluorobenzenboronic acid
  • Boronic acid, B-(4-chloro-2-fluorophenyl)-
  • 1-Borono-4-chloro-2-fluorobenzene
  • 2-fluoro-4-chlorophenylboronic acid
  • 4-Chloro-2-fluorobenzeneboronic acid (contains varying aMounts of anhydride)
  • B-(4-chloro-2-fluorophenyl)-Boronic acid
  • 4-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
  • 4-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride) &gt
  • 4-Chloro-2-fluorophenylboronic acid，98%
  • 4-Chloro-2-fluorobenzeneboronic acid - [C20549]
  • 160591-91-3
  • 16059-91-3
  • C6H6BClFO2
  • Aryl
  • Organoborons
  • blocks
  • BoronicAcids