4-Chloro-2-fluorophenylboronic acid
- Product Name
- 4-Chloro-2-fluorophenylboronic acid
- CAS No.
- 160591-91-3
- Chemical Name
- 4-Chloro-2-fluorophenylboronic acid
- Synonyms
- AKOS BRN-0717;1-Borono-4-chloro-2-fluorobenzene;4-CHLORO-2-FLUOROPHENYLBORONIC ACID;4-chloro-2-fluorobenzenboronic acid;2-fluoro-4-chlorophenylboronic acid;4-CHLORO-2-FLUOROBENZENEBORONIC ACID;4-Chloro-2-fluorobenzeneboronicacid98%;4-Chloro-2-fluorophenylboronic acid，98%;B-(4-chloro-2-fluorophenyl)-Boronic acid;4-Chloro-2-fluorobenzeneboronic acid 98%
- CBNumber
- CB0271596
- Molecular Formula
- C6H5BClFO2
- Formula Weight
- 174.37
- MOL File
- 160591-91-3.mol
4-Chloro-2-fluorophenylboronic acid Property
- Melting point:
- 248-250
- Boiling point:
- 289.2±50.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 8.19±0.58(Predicted)
- color
- White to Light yellow
- Water Solubility
- Insoluble in water.
- InChI
- InChI=1S/C6H5BClFO2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,10-11H
- InChIKey
- YBNDRTRLXPEWKQ-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(Cl)C=C1F)(O)O
- CAS DataBase Reference
- 160591-91-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-36
- Safety Statements
- 26-36/37/39-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- BML00162
- Product name
- 4-Chloro-2-fluorophenylboronic acid
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $42.8
- Updated
- 2025/07/31
- Product number
- C3048
- Product name
- 4-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- C3048
- Product name
- 4-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $82
- Updated
- 2025/07/31
- Product number
- C584620
- Product name
- 4-Chloro-2-fluorophenylboronic acid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C584620
- Product name
- 4-Chloro-2-fluorophenylboronic acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
4-Chloro-2-fluorophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Uses
Used as intermediates for pharmaceutical and agrochemicals.
Uses
suzuki reaction
Synthesis
121-43-7
1996-29-8
7732-18-5
160591-91-3
To a 2L round bottom flask was added 1-bromo-4-chloro-2-fluorobenzene (50 g, 238.7 mmol) and anhydrous tetrahydrofuran (900 ml), and the mixture was cooled to -78°C with stirring. Slowly n-butyllithium (2.5 M hexane solution, 100 ml, 250 mmol) was added dropwise and stirred continuously for 1 hour at this temperature. Subsequently, trimethyl borate (31.9 ml, 286 mmol) was added slowly and the reaction was continued for 30 minutes. After completion of the reaction, 1N aqueous hydrochloric acid solution (600 ml) was added and gradually warmed up to room temperature while stirring. The organic layer was separated, dried with anhydrous magnesium sulfate and filtered. The solvent was removed by distillation under reduced pressure, and the concentrated product was extracted with a mixture of chloroform and hexane solvents, and finally purified by recrystallization to afford 4-chloro-2-fluorophenylboronic acid (33.7 g, 193.3 mmol) in 81% yield.
References
[1] Patent: KR101680413, 2016, B1. Location in patent: Paragraph 0129-0132
4-Chloro-2-fluorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-2-fluorophenylboronic acid Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 4-Chloro-2-fluorophenylboronic acid manufacturers
- Product
- 4-Chloro-2-fluorophenylboronic acid 160591-91-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-13
- Product
- 4-Chloro-2-fluorophenylboronic acid 160591-91-3
- Price
- US $35.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 Ton
- Release date
- 2023-10-27
- Product
- 4-Chloro-2-fluorophenylboronic acid 160591-91-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 30000 Kg
- Release date
- 2023-11-28