7-INDAZOLE CARBOXYLIC ACID METHYL ESTER
- Product Name
- 7-INDAZOLE CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 952479-65-1
- Chemical Name
- 7-INDAZOLE CARBOXYLIC ACID METHYL ESTER
- Synonyms
- METHYL 1H-INDAZOLE-7-CARBOXYLATE;Methyl 2H-indazole-7-carboxylate;7-INDAZOLE CARBOXYLIC ACID METHYL ESTER;2H-Indazole-7-carboxylic acid methyl ester
- CBNumber
- CB3666898
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- Mol file
7-INDAZOLE CARBOXYLIC ACID METHYL ESTER Property
- Boiling point:
- 232.7±23.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.39±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0044212
- Product name
- Methyl2H-indazole-7-carboxylate
- Packaging
- 100mg
- Price
- $76
- Updated
- 2021/12/16
- Product number
- CS-0044212
- Product name
- Methyl2H-indazole-7-carboxylate
- Packaging
- 250mg
- Price
- $113
- Updated
- 2021/12/16
- Product number
- CS-0044212
- Product name
- Methyl2H-indazole-7-carboxylate
- Packaging
- 1g
- Price
- $233
- Updated
- 2021/12/16
- Product number
- CHM0392946
- Product name
- METHYL-2H-INDAZOLE-7-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.72
- Updated
- 2021/12/16
- Product number
- 6378AC
- Product name
- Methyl2H-indazole-7-carboxylate
- Packaging
- 5g
- Price
- $1162
- Updated
- 2021/12/16
7-INDAZOLE CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
22223-49-0
755752-82-0
General procedure for the synthesis of methyl 1H-indazole-7-carboxylate from methyl 2-amino-3-methylbenzoate: To a solution of methyl 2-amino-3-methylbenzoate (17.5 g, 106 mmol) in chloroform (300 mL) was slowly added acetic anhydride (22.6 mL, 239 mmol, 2.3 eq.), and the temperature of the reaction was controlled to be lower than 40 °C. After addition, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, potassium acetate (3.00 g, 30.6 mmol, 0.3 eq.) and isoamyl nitrite (30.6 mL, 228 mmol, 2.2 eq.) were added and the reaction mixture was heated to reflux for 24 hours. After the reaction was completed, it was cooled to room temperature. The reaction mixture was washed with saturated aqueous sodium bicarbonate, the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. Methanol (100 mL) and 6N hydrochloric acid (100 mL) were added to the residue and stirred at room temperature for 18 hours. The solvent was removed under reduced pressure and the residue was ground with ethyl acetate (100 mL). The solid product was collected by filtration, washed with ethyl acetate (20 mL) and dried to give 15.3 g (68% yield) of methyl 1H-indazole-7-carboxylate hydrochloride. The product was characterized by 1H NMR (500 MHz, DMSO-d6) and mass spectrometry (APCI): 1H NMR δ 13.3 (bs, 1H), 8.26 (d, 1H), 8.12 (d, 1H), 8.25 (dd, 1H), 7.27 (t, 1H), 3.97 (s, 3H); MS (APCI) m/z 177 (M++1) .
References
[1] Patent: WO2004/29050, 2004, A1. Location in patent: Page 64
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937
[3] Journal of Organic Chemistry, 2016, vol. 81, # 15, p. 6855 - 6861
[4] Patent: WO2007/121578, 2007, A1. Location in patent: Page/Page column 29
[5] Patent: WO2008/65508, 2008, A1
7-INDAZOLE CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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