1H-INDAZOLE-7-CARBOXYLIC ACID

Product Name: 1H-INDAZOLE-7-CARBOXYLIC ACID
CAS No.: 755752-82-0
Chemical Name: 1H-INDAZOLE-7-CARBOXYLIC ACID
Synonyms: Niraparib Intermediate5;7-INDAZOLE CARBOXYLLIC ACID;Methyl indazole-7-carboxy...;Methyl indazole-7-carboxylate;Methyl 1H-Indazole-7-carboxyate;7-(Methoxycarbonyl)-1H-indazole;1H-Indazole-7-carboxylic acid methyl ester;7-(1H)Indazole carboxylic acid Methyl ester;1H-Indazole-7-carboxylic acid methyl ester
CBNumber: CB2197276
Molecular Formula: C9H8N2O2
Formula Weight: 176.17
MOL File: 755752-82-0.mol

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1H-INDAZOLE-7-CARBOXYLIC ACID Property

Boiling point:: 345.2±15.0 °C(Predicted)
Density: 1.324
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 11.93±0.40(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C9H8N2O2/c1-13-9(12)7-4-2-3-6-5-10-11-8(6)7/h2-5H,1H3,(H,10,11)
InChIKey: GEWJEKADAXWFPY-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC=C2C(OC)=O)C=N1
CAS DataBase Reference: 755752-82-0

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Safety

WGK Germany: 3
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00166
Product name: 1H-Indazole-7-carboxylic acid methyl ester
Purity: Aldrich
Packaging: 1g
Price: $185
Updated: 2025/07/31

TRC

Product number: M313528
Product name: Methylindazole-7-carboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M313528
Product name: Methylindazole-7-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: M313528
Product name: Methylindazole-7-carboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR30717
Product name: Methyl1H-indazole-7-carboxylate
Purity: 98%
Packaging: 5g
Price: $61
Updated: 2021/12/16

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1H-INDAZOLE-7-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

22223-49-0

755752-82-0

General procedure for the synthesis of methyl 1H-indazole-7-carboxylate from methyl 2-amino-3-methylbenzoate: To a solution of methyl 2-amino-3-methylbenzoate (17.5 g, 106 mmol) in chloroform (300 mL) was slowly added acetic anhydride (22.6 mL, 239 mmol, 2.3 eq.), and the temperature of the reaction was controlled to be lower than 40°C. The reaction mixture was stirred for 1 hour at room temperature. The reaction mixture was stirred at room temperature for 1 hour and then potassium acetate (3.00 g, 30.6 mmol, 0.3 eq.) and isoamyl nitrite (30.6 mL, 228 mmol, 2.2 eq.) were added sequentially. The reaction mixture was heated to reflux for 24 hours and subsequently cooled to room temperature. The reaction mixture was washed with saturated aqueous sodium bicarbonate, the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. Methanol (100 mL) and 6N hydrochloric acid (100 mL) were added to the residue and the mixture was stirred at room temperature for 18 hours. The volatiles were removed under reduced pressure and the residue was ground with ethyl acetate (100 mL). The solid product was separated by filtration, washed with ethyl acetate (20 mL) and dried to give 15.3 g (68% yield) of methyl 1H-indazole-7-carboxylate hydrochloride. Product characterization data: 1H NMR (500 MHz, DMSO-d6) δ; 13.3 (broad peak, 1H), 8.26 (double peak, 1H), 8.12 (double peak, 1H), 8.25 (double-double peak, 1H), 7.27 (triple peak, 1H), 3.97 (single peak, 3H); MS (APCI) m/z 177 (M++1).

References

[1] Patent: WO2004/29050, 2004, A1. Location in patent: Page 64
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937
[3] Journal of Organic Chemistry, 2016, vol. 81, # 15, p. 6855 - 6861
[4] Patent: WO2007/121578, 2007, A1. Location in patent: Page/Page column 29
[5] Patent: WO2008/65508, 2008, A1

1H-INDAZOLE-7-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-INDAZOLE-7-CARBOXYLIC ACID Suppliers

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View Lastest Price from 1H-INDAZOLE-7-CARBOXYLIC ACID manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1H-INDAZOLE-7-CARBOXYLIC ACID 755752-82-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-09

Nanjing Fred Technology Co., Ltd

Product: Methyl 1H-Indazole-7-carboxyate 755752-82-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-25

Career Henan Chemical Co

Product: 1H-INDAZOLE-7-CARBOXYLIC ACID 755752-82-0
Price: US $500.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-04

755752-82-0, 1H-INDAZOLE-7-CARBOXYLIC ACIDRelated Search:

5-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID METHYL ESTER 5-Amino-1H-indazole-3-carboxylic acid methyl ester,1H-Indazole-3-carboxylic acid, 5-amino-, methyl ester 1H-Indazole-3-carboxylic acid, 6-bromo- INDAZOLE-5-CARBOXYLIC ACID METHYL ESTER 1-[2,4-DICHLOROBENZYL]-1H-INDAZOLE-3-CARBOXYLIC ACID 1H-indazole-7-carboxylic acid ETHYL 1H-INDAZOLE-7-CARBOXYLATE 7-METHOXYCARBONYL-1H-INDAZOLE-3-CARBOXYLIC ACID 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER 5-NITRO-1H-INDAZOLE-7-CARBOXYLIC ACID METHYL ESTER 3-FORMYL-7-INDAZOLE CARBOXYLIC ACID METHYL ESTER 7-methyl-1H-indazole-3-carboxylic acid 1H-INDAZOLE-7-CARBOXYLIC ACID INDAZOLE-4-CARBOXYLIC ACID METHYL ESTER 7-fluoro-1H-indazole-3-carboxylic acid 1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid 1-METHYL-1H-INDAZOLE-6-CARBOXYLIC ACID 1-(2-chlorophenyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid

Methyl indazole-7-carboxylate

1H-Indazole-7-carboxylic acid methyl ester

7-INDAZOLE CARBOXYLLIC ACID

Methyl indazole-7-carboxy...

7-(Methoxycarbonyl)-1H-indazole

7-(1H)Indazole carboxylic acid Methyl ester

Niraparib Intermediate5

Methyl 1H-Indazole-7-carboxyate

1<i>H</i>-Indazole-7-carboxylic acid methyl ester

755752-82-0

Indazoles