ChemicalBook > CAS DataBase List > 1H-INDAZOLE-7-CARBOXYLIC ACID
1H-INDAZOLE-7-CARBOXYLIC ACID
- Product Name
- 1H-INDAZOLE-7-CARBOXYLIC ACID
- CAS No.
- 755752-82-0
- Chemical Name
- 1H-INDAZOLE-7-CARBOXYLIC ACID
- Synonyms
- Niraparib Intermediate5;7-INDAZOLE CARBOXYLLIC ACID;Methyl indazole-7-carboxy...;Methyl indazole-7-carboxylate;Methyl 1H-Indazole-7-carboxyate;7-(Methoxycarbonyl)-1H-indazole;1H-Indazole-7-carboxylic acid methyl ester;7-(1H)Indazole carboxylic acid Methyl ester;1H-Indazole-7-carboxylic acid methyl ester
- CBNumber
- CB2197276
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 755752-82-0.mol
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1H-INDAZOLE-7-CARBOXYLIC ACID Property
- Boiling point:
- 345.2±15.0 °C(Predicted)
- Density
- 1.324
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 11.93±0.40(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C9H8N2O2/c1-13-9(12)7-4-2-3-6-5-10-11-8(6)7/h2-5H,1H3,(H,10,11)
- InChIKey
- GEWJEKADAXWFPY-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2C(OC)=O)C=N1
- CAS DataBase Reference
- 755752-82-0
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Safety
- WGK Germany
- 3
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SYX00166
- Product name
- 1H-Indazole-7-carboxylic acid methyl ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $185
- Updated
- 2025/07/31
TRC
- Product number
- M313528
- Product name
- Methylindazole-7-carboxylate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- M313528
- Product name
- Methylindazole-7-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
TRC
- Product number
- M313528
- Product name
- Methylindazole-7-carboxylate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR30717
- Product name
- Methyl1H-indazole-7-carboxylate
- Purity
- 98%
- Packaging
- 5g
- Price
- $61
- Updated
- 2021/12/16
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1H-INDAZOLE-7-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
22223-49-0
755752-82-0
General procedure for the synthesis of methyl 1H-indazole-7-carboxylate from methyl 2-amino-3-methylbenzoate: To a solution of methyl 2-amino-3-methylbenzoate (17.5 g, 106 mmol) in chloroform (300 mL) was slowly added acetic anhydride (22.6 mL, 239 mmol, 2.3 eq.), and the temperature of the reaction was controlled to be lower than 40°C. The reaction mixture was stirred for 1 hour at room temperature. The reaction mixture was stirred at room temperature for 1 hour and then potassium acetate (3.00 g, 30.6 mmol, 0.3 eq.) and isoamyl nitrite (30.6 mL, 228 mmol, 2.2 eq.) were added sequentially. The reaction mixture was heated to reflux for 24 hours and subsequently cooled to room temperature. The reaction mixture was washed with saturated aqueous sodium bicarbonate, the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. Methanol (100 mL) and 6N hydrochloric acid (100 mL) were added to the residue and the mixture was stirred at room temperature for 18 hours. The volatiles were removed under reduced pressure and the residue was ground with ethyl acetate (100 mL). The solid product was separated by filtration, washed with ethyl acetate (20 mL) and dried to give 15.3 g (68% yield) of methyl 1H-indazole-7-carboxylate hydrochloride. Product characterization data: 1H NMR (500 MHz, DMSO-d6) δ; 13.3 (broad peak, 1H), 8.26 (double peak, 1H), 8.12 (double peak, 1H), 8.25 (double-double peak, 1H), 7.27 (triple peak, 1H), 3.97 (single peak, 3H); MS (APCI) m/z 177 (M++1).
References
[1] Patent: WO2004/29050, 2004, A1. Location in patent: Page 64
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937
[3] Journal of Organic Chemistry, 2016, vol. 81, # 15, p. 6855 - 6861
[4] Patent: WO2007/121578, 2007, A1. Location in patent: Page/Page column 29
[5] Patent: WO2008/65508, 2008, A1
1H-INDAZOLE-7-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-INDAZOLE-7-CARBOXYLIC ACID manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 1H-INDAZOLE-7-CARBOXYLIC ACID 755752-82-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-09
Nanjing Fred Technology Co., Ltd
- Product
- Methyl 1H-Indazole-7-carboxyate 755752-82-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-25
Career Henan Chemical Co
- Product
- 1H-INDAZOLE-7-CARBOXYLIC ACID 755752-82-0
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04
755752-82-0, 1H-INDAZOLE-7-CARBOXYLIC ACIDRelated Search:
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