Methyl 1H-indazole-5-carboxylate
- Product Name
- Methyl 1H-indazole-5-carboxylate
- CAS No.
- 473416-12-5
- Chemical Name
- Methyl 1H-indazole-5-carboxylate
- Synonyms
- Methyl indazole-5-carboxy...;5-Carboxyindazole Methyl este;Methyl indazole-5-carboxylate;5-CARBOXYINDAZOLE METHYL ESTER;Methyl 5-1H-indazolecarboxylate;5-(Methoxycarbonyl)-1H-indazole;1-(1H-indazol-5-yl)propan-1-one;Methyl 1H-indazol-5-carboxylate;METHYL 1H-INDAZOLE-5-CARBOXYLATE;INDAZOLE-5-CARBOXYLIC ACID METHYL ESTER
- CBNumber
- CB2105402
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 473416-12-5.mol
Methyl 1H-indazole-5-carboxylate Property
- Boiling point:
- 345.2±15.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.81±0.40(Predicted)
- form
- solid
- color
- Orange
- InChI
- InChI=1S/C9H8N2O2/c1-13-9(12)6-2-3-8-7(4-6)5-10-11-8/h2-5H,1H3,(H,10,11)
- InChIKey
- LPLOEZPPYOSNEW-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(C(OC)=O)C=C2)C=N1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CVT00048
- Product name
- Methyl 1H-indazole-5-carboxylate
- Packaging
- 1g
- Price
- $259
- Updated
- 2025/07/31
- Product number
- M313533
- Product name
- Methylindazole-5-carboxylate
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 069834
- Product name
- 1H-Indazole-5-carboxylic acid methyl ester
- Purity
- 97%
- Packaging
- 5g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- OR30715
- Product name
- Methyl 1H-indazole-5-carboxylate
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4H23-1-24
- Product name
- Methyl 1H-indazole-5-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
Methyl 1H-indazole-5-carboxylate Chemical Properties,Usage,Production
Uses
5-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER is a versatile compound commonly utilized in chemical synthesis as a key building block for the creation of various organic molecules.
Synthesis
67-56-1
61700-61-6
473416-12-5
Concentrated sulfuric acid (0.2 mL) was slowly added to a methanolic (5 mL) suspension of 1H-indazole-5-carboxylic acid (470 mg, 2.9 mmol). The reaction mixture was heated to 70 °C and the reaction was stirred at this temperature overnight. Upon completion of the reaction, the mixture was cooled to room temperature and diluted and neutralized by adding water (10 mL), saturated aqueous sodium bicarbonate (5 mL), and ethyl acetate (30 mL) in that order. The organic and aqueous phases were separated and the aqueous phase was extracted once more with ethyl acetate (30 mL). All organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to afford methyl 1H-indazole-5-carboxylate (466 mg, 2.65 mmol, 88% yield) as a light pink to yellow solid. Mass spectrometry analysis showed that the measured value of C9H8N2O2 was (M + H)+ 176.9.
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 470 - 492
[2] Patent: WO2013/78237, 2013, A1. Location in patent: Page/Page column 81; 82
[3] Patent: WO2016/196776, 2016, A2. Location in patent: Paragraph 00725
[4] Patent: WO2013/96496, 2013, A2. Location in patent: Page/Page column 26
Methyl 1H-indazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 1H-indazole-5-carboxylate manufacturers
- Product
- 5-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER 473416-12-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09