5-Carboxyindazole hydrochloride
- Product Name
- 5-Carboxyindazole hydrochloride
- CAS No.
- 61700-61-6
- Chemical Name
- 5-Carboxyindazole hydrochloride
- Synonyms
- 1H-INDAZOLE-5-CARBOXYLIC ACID;5-(1H)INDAZOLE CARBOXYLIC ACID;100287;5-CARBOXYINDAZOLE HCL;5-Carboxy-1H-indazole;5-INDAZOLECARBOXYLIC ACID;1H-INDAZOLE-5-CARBOXYLATE;INDAZOLE-5-CARBOXYLIC ACID;1H-Indazole-5-carboxylic ...;1H-5-indazolecarboxylic acid
- CBNumber
- CB5140334
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 61700-61-6.mol
5-Carboxyindazole hydrochloride Property
- Melting point:
- >250℃
- Boiling point:
- 443.7±18.0 °C(Predicted)
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.03±0.30(Predicted)
- form
- Spherical Beads
- color
- Yellow to amber
- InChIKey
- MAVGBUDLHOOROM-UHFFFAOYSA-N
- CAS DataBase Reference
- 61700-61-6(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 702455
- Product name
- 1H-Indazole-5-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $50.9
- Updated
- 2025/07/31
- Product number
- I509048
- Product name
- 1H-Indazole-5-carboxylic acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 057942
- Product name
- 1H-Indazole-5-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- J54230
- Product name
- 1H-Indazole-5-carboxylic acid
- Packaging
- 1g
- Price
- $17
- Updated
- 2021/12/16
- Product number
- OR60062
- Product name
- 1H-Indazole-5-carboxylic acid
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
5-Carboxyindazole hydrochloride Chemical Properties,Usage,Production
Uses
1H-Indazole-5-carboxylic Acid is used as a reactant in the synthesis of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists.
Synthesis
473416-12-5
61700-61-6
General procedure for the synthesis of indazole-5-carboxylic acid hydrochloride from methyl 1H-indazole-5-carboxylate: 1H-indazole-5-carboxylic acid methyl ester (6.5 g, 1.0 eq.) and 200 mL of methanol (MeOH) were added to a stirred 1 L reaction flask, followed by a solution of sodium hydroxide (NaOH, 4.4 g, 3.0 eq.) dissolved in 150 mL of water (H2O). The reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, the organic solvent was evaporated under reduced pressure. The remaining aqueous phase was washed with ethyl acetate (EtOAc) and then acidified with 3N hydrochloric acid (HCl) to pH=5~6. The precipitate was collected by filtration and washed with deionized water to afford the target product, indazole-5-carboxylic acid hydrochloride, as a yellow solid (6.2 g, 98% yield).
References
[1] Patent: WO2013/97773, 2013, A1. Location in patent: Paragraph 0261
[2] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 40
[3] Patent: WO2014/66743, 2014, A1. Location in patent: Paragraph 0146
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8219 - 8248
5-Carboxyindazole hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Carboxyindazole hydrochloride manufacturers
- Product
- 1H-Indazole-5-carboxylic acid 61700-61-6
- Price
- US $34.00-282.00/g
- Min. Order
- 25g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-12-29
- Product
- 1H-Indazole-5-carboxylic acid 61700-61-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 5-Carboxyindazole hydrochloride 61700-61-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09