ChemicalBook > CAS DataBase List > 2-(Trimethylsilyl)ethanol

2-(Trimethylsilyl)ethanol

Product Name
2-(Trimethylsilyl)ethanol
CAS No.
2916-68-9
Chemical Name
2-(Trimethylsilyl)ethanol
Synonyms
2-(triMethylsilyl)ethan-1-ol;Ethanol, 2-(trimethylsilyl)-;trimethylsilylethanol;DK254;DK717;0.825 g/ML;DKFELEX0184;2-(TrimethyL;TIMTEC-BB SBB009030;2-(TriMethylsiyl)ethanol
CBNumber
CB3668443
Molecular Formula
C5H14OSi
Formula Weight
118.25
MOL File
2916-68-9.mol
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2-(Trimethylsilyl)ethanol Property

Boiling point:
71-73 °C35 mm Hg(lit.)
Density 
0.825 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.423(lit.)
Flash point:
123 °F
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
pka
15.38±0.10(Predicted)
form 
Liquid
color 
Clear colorless
Specific Gravity
0.825
Water Solubility 
soluble
Hydrolytic Sensitivity
4: no reaction with water under neutral conditions
BRN 
1732034
Stability:
Hygroscopic
InChIKey
ZNGINKJHQQQORD-UHFFFAOYSA-N
CAS DataBase Reference
2916-68-9(CAS DataBase Reference)
NIST Chemistry Reference
Trimethyl-2-hydroxyethylsilane(2916-68-9)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
10-36/37/38
Safety Statements 
16-37/39-26-24/25
RIDADR 
UN 1987 3/PG 3
WGK Germany 
3
RTECS 
KM5480000
Hazard Note 
Flammable
TSCA 
No
HazardClass 
3
PackingGroup 
III
HS Code 
29310095
Toxicity
mouse,LD50,intraperitoneal,1122mg/kg (1122mg/kg),Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. Vol. 229, Pg. 1011, 1976.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
226890
Product name
2-(Trimethylsilyl)ethanol
Purity
98%
Packaging
1g
Price
$37.6
Updated
2024/03/01
Sigma-Aldrich
Product number
226890
Product name
2-(Trimethylsilyl)ethanol
Purity
98%
Packaging
10g
Price
$82.8
Updated
2024/03/01
TCI Chemical
Product number
T1441
Product name
2-(Trimethylsilyl)ethanol
Purity
>96.0%(GC)
Packaging
5mL
Price
$61
Updated
2024/03/01
TCI Chemical
Product number
T1441
Product name
2-(Trimethylsilyl)ethanol
Purity
>96.0%(GC)
Packaging
25mL
Price
$198
Updated
2024/03/01
Alfa Aesar
Product number
B20970
Product name
2-(Trimethylsilyl)ethanol, 98+%
Packaging
5g
Price
$79.65
Updated
2024/03/01
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2-(Trimethylsilyl)ethanol Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Physical properties

bp 50–52 °C/10 mmHg, 71–73 °C/35 mmHg; d 0.825 g cm?3.

Uses

2-(Trimethylsilyl)ethanol is used as a protecting reagent for carboxyl, phosphoryl, hydroxyl and amino group in organic synthesis. It is used as a precursor to prepare trimethyl(2-phenoxyethyl)silanes by reacting with aromatic fluoride. It is also used in the synthesis of teoc-protected amines by using the corresponding isocyanates.

Uses

Used to synthesize Teoc-protected amines via alcoholysis of the corresponding isocyanates.

Uses

2-(Trimethylsilyl)ethanol is a protecting reagent for carboxyl, phosphoryl, hydroxyl, and amino groups. It participates in the reactions of Phenol and Acid Protection, Alcohol Protection, Hemiacetal Protection, Amine Protection, Enol Ether Synthesis, Carbohydrate Chemistry etc.

Preparation

Three methods of preparation have been reported: (a) from the treatment of ethyl bromoacetate with zinc followed by the reaction with chlorotrimethylsilane1 and subsequent reduction of the resultant ethyl trimethylsilylacetate with lithium aluminum hydride2,3 or borane¨Ctetrahydrofuran(eq 1); (b) from the hydroboration/oxidation or oxymercuration/demercuration of vinyltrimethylsilane (eq 2); and (c)most conveniently, by the reaction of the Grignard reagent formed from (chloromethyl)trimethylsilane with paraformaldehyde (eq 3).

Purification Methods

If the NMR spectrum is not clean, then dissolve the alcohol in Et2O, wash it with aqueous NH4Cl solution, dry (Na2SO4), evaporate and distil it. The 3,4-dinitrobenzoyl derivative has m 66o (from EtOH). [NMR: Speier et al. J Am Chem Soc 79 974 1957, Z Naturforsch 14b 137 1959, Beilstein 4 IV 3951.]

2-(Trimethylsilyl)ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(Trimethylsilyl)ethanol manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
2-(Trimethylsilyl)ethanol 2916-68-9
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-19
Hebei Weibang Biotechnology Co., Ltd
Product
2-(Trimethylsilyl)ethanol 2916-68-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-11-04
Henan Aochuang Chemical Co.,Ltd.
Product
2-(Trimethylsilyl)ethanol 2916-68-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-19

2916-68-9, 2-(Trimethylsilyl)ethanolRelated Search:

TRIMETHYLSULFOXONIUM CHLORIDE N-(Trimethylsilyl)acetamide allyltrimethylammonium chloride Benzyltrimethylammonium chloride 2-Methoxyethanol Ethanol Vinyltrimethoxysilane Ethyl acetate Silicone rubber,methyl-vinyl 3-(TRIMETHYLSILYL)-1,2-PROPANEDIOL TERT-BUTYL TRIMETHYLSILYLACETATE FMOC-TYR(PO3(MDPSE)2)-OH (TRIMETHYLSILYL)ACETIC ACID 2-(Trimethylsilyl)ethoxymethyl chloride 2-(METHYLDIPHENYLSILYL)ETHANOL Ethyl (trimethylsilyl)acetate METHYL (TRIMETHYLSILYL)ACETATE 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE

  • 2-HYDROXYETHYLTRIMETHYLSILANE
  • 2-(TRIMETHYLSILYL)ETHANOL
  • 2-(TRIMETHYLSILYL)ETHANAL
  • 2-(trimethylsilyl)-ethano
  • TIMTEC-BB SBB009030
  • 2-(TRIMETHYLSILYL)ETHANOL, 97%2-(TRIMETHYLSILYL)ETHANOL, 97%2-(TRIMETHYLSILYL)ETHANOL, 97%
  • Ethanol, 2-(trimethylsilyl)-
  • Silane, (2-hydroxyethyl)trimethyl-
  • trimethylsilylethanol
  • (2-hydroxyethyl)trimethyl-silan
  • 2-(TRIMETHYLSILYL)ETHANOL, 98+%
  • 2-(Trimethylsilyl)ethyl alcohol
  • 2-(Trimethylsilyl)ethanol,99%
  • 2-(triMethylsilyl)ethan-1-ol
  • 2-(TriMethylsilyl)ethanol, 99% 10ML
  • 0.825 g/ML
  • 2-Trimethylsilanyl-ethanol
  • 2-(TriMethylsiyl)ethanol
  • 2-(TrimethyL
  • 2-(Trimethylsilyl)ethanol, 98%, for synthesis
  • DK254
  • DK717
  • DKFELEX0184
  • 2916-68-9
  • CH33SiCH2CH2OH
  • C5H14OSi
  • C5H14SiO
  • Si-(C)4 Compounds
  • Silicon Compounds (for Synthesis)
  • Si (Classes of Silicon Compounds)
  • Protecting and Derivatizing Reagents
  • Protection and Derivatization
  • Silicon-Based
  • Synthetic Reagents
  • Si (Classes of Silicon Compounds)
  • Si-(C)4 Compounds
  • Silicon Compounds (for Synthesis)
  • Synthetic Organic Chemistry
  • Alcohols and Derivatives
  • bc0001