4-(2-Chloroethyl)morpholine

Product Name: 4-(2-Chloroethyl)morpholine
CAS No.: 3240-94-6
Chemical Name: 4-(2-Chloroethyl)morpholine
Synonyms: N-CHLOROETHYLMORPHOLINE;tl401;TIMTEC-BB SBB004079;morpholinoethylchloride;2-morpholinoethylchloride;beta-chloroethylmorpholine;1-(2-Chloroethyl)Morpholine;4-(2-chloroethyl)-morpholin;beta-morpholinoethylchloride;N-(2-Chloroethyl)-morpholine
CBNumber: CB3672853
Molecular Formula: C6H12ClNO
Formula Weight: 149.62
MOL File: 3240-94-6.mol

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4-(2-Chloroethyl)morpholine Property

Boiling point:: 94°C/12mmHg(lit.)
Density: 1.0823 (rough estimate)
refractive index: 1.4750 to 1.4790
storage temp.: Storage temp. -20°C
pka: 6.15±0.10(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C6H12ClNO/c7-1-2-8-3-5-9-6-4-8/h1-6H2
InChIKey: ZAPMTSHEXFEPSD-UHFFFAOYSA-N
SMILES: N1(CCCl)CCOCC1
CAS DataBase Reference: 3240-94-6(CAS DataBase Reference)
EPA Substance Registry System: Morpholine, 4-(2-chloroethyl)- (3240-94-6)

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Safety

RIDADR: UN 2922 8/6.1/PG III
RTECS: QE0175000
HazardClass: 8/6.1
PackingGroup: III
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3061
Product name: 4-(2-Chloroethyl)morpholine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $122
Updated: 2021/12/16

TRC

Product number: C363290
Product name: 4-(2-Chloroethyl)morpholine
Packaging: 500mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C363290
Product name: 4-(2-Chloroethyl)morpholine
Packaging: 1g
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: OR903887
Product name: 4-(2-Chloroethyl)morpholine
Purity: 98%
Packaging: 5g
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139778
Product name: 4-(2-Chloroethyl)morpholine
Packaging: 5G
Price: $80
Updated: 2021/12/16

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4-(2-Chloroethyl)morpholine Chemical Properties,Usage,Production

Uses

4-(2-Chloroethyl)morpholine

Synthesis

622-40-2

3240-94-6

Thionyl chloride (69.44 mmol, 5.06 mL, 5.0 eq.) was slowly added to a stirred solution of 2-morpholinoethan-1-ol (13.88 mmol, 2.5 g, 1.0 eq.) in dichloromethane (25 mL) with a catalytic amount of DMF at 0 °C. The reaction mixture was heated to 40 °C overnight. The reaction progress was monitored by TLC. After completion of the reaction, the solvent was removed by vacuum evaporation to give the crude product. The crude product was diluted with dichloromethane and washed with saturated sodium bicarbonate solution. The organic layer was concentrated under reduced pressure to give the crude residue. The crude product was purified by column chromatography using dichloromethane solution containing 3% methanol as eluent to afford the target compound 4-(2-chloroethyl)morpholine (2.0 g, 74.0% yield) as a colorless liquid.1H NMR (DMSO-d6, 300 MHz): δ 3.69 (t, J = 6.9 Hz, 2H), 3.57 (m, J = 4.5 Hz, 4H ), 2.64 (t, J = 6.9 Hz, 2H), 2.43 (t, J = 4.5 Hz, 4H); MS: [M + H]+ 149.95 (10%).

References

[1] Patent: WO2017/149518, 2017, A1. Location in patent: Page/Page column 25; 26
[2] Patent: WO2018/29604, 2018, A1. Location in patent: Page/Page column 47
[3] Journal of the American Chemical Society, 1940, vol. 62, p. 1443,1446
[4] Journal of the American Pharmaceutical Association (1912-1977), 1953, vol. 42, p. 342
[5] Journal of the Indian Chemical Society, 1959, vol. 36, p. 349,352

4-(2-Chloroethyl)morpholine Preparation Products And Raw materials

Raw materials

Preparation Products

2-(2-MORPHOLIN-4-YLETHOXY)ANILINE

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4-(2-Chloroethyl)morpholine Suppliers

China 128 Europe 2 Germany 2 India 4 Switzerland 1 United Kingdom 1 United States 12 Global 150

Henan Weituxi Chemical Technology Co., Ltd.

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Energy Chemical

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Tongchuang Pharma(Suzhou). Co., Ltd.

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Yangzhou Hopechem Co., Ltd.

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View Lastest Price from 4-(2-Chloroethyl)morpholine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(2-Chloroethyl)morpholine 3240-94-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-10

Career Henan Chemical Co

Product: 4-(2-Chloroethyl)morpholine 3240-94-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg, 5kg ,50kg
Release date: 2020-01-08

3240-94-6, 4-(2-Chloroethyl)morpholineRelated Search:

N-(2,2-DICHLORO-1-MORPHOLINOETHYLIDENE)-N'-[2-(2,4-DICHLOROPHENOXY)PHENYL]UREA 4-[CHLORO(PHENYL)ACETYL]MORPHOLINE 4-(2-CHLOROACETYL)MORPHOLINE TRIMORPHAMID 4-(2-Chloroethyl)morpholine hydrochloride 4-(2-chloropropanoyl)-2-methylmorpholine TIMTEC-BB SBB010861 4-(CHLOROACETYL)-2-METHYLMORPHOLINE 4-(8,8-DICHLORO-4,6,6-TRIMETHYL-3-OXATRICYCLO[5.1.0.0(2,4)]OCT-1-YL)MORPHOLINE N-(2,2-DICHLORO-1-MORPHOLINOETHYLIDENE)-N'-(5-METHYLISOXAZOL-3-YL)UREA 4-[2-CHLORO-2-(PHENYLSULFONYL)ETHYL]-1,4-OXAZINAN-4-IUM CHLORIDE 3(2H)-Pyridazinone, 6-chloro-5-(4-morpholinyl)-, hydrazone, sulfate (1 :1) 4-(2-Chloroethyl)morpholine

TIMTEC-BB SBB004079

N-CHLOROETHYLMORPHOLINE

4-(2-CHLORO-ETHYL)-MORPHOLINE

2-(4-morpholinyl)ethylchloride

2-morpholinoethylchloride

4-(2-chloroethyl)-morpholin

beta-chloroethylmorpholine

beta-morpholinoethylchloride

morpholinoethylchloride

tl401

1-(2-Chloroethyl)Morpholine

N-(2-Chloroethyl)-morpholine

4-(2-CHLOROETHYL) MORPHOLINE HYDROCHLORI DE(OTHER CMPNDS CNTNG AN UNFUSED PYRDN R ING(W/N HYDRGNTD)IN STRUCTURE)(DRUG INTE

Morpholine,4-(2-chloroethyl)-

Galactose Impurity 3 (Galactose EP Impurity C)

3240-94-6

Thiadiazoles