4-(2-Chloroethyl)morpholine hydrochloride

Product Name: 4-(2-Chloroethyl)morpholine hydrochloride
CAS No.: 3647-69-6
Chemical Name: 4-(2-Chloroethyl)morpholine hydrochloride
Synonyms: MOC;Morpholine, 4-(2-chloroethyl)-, hydrochloride;MOCPRF;4-(2-ChL;ine hydrochL;Chloroethyl Morpholine HCI;Vortioxetine Impurity 70 HCl;2-ChloroethylmorpholineHcl98%;Vortioxetine Impurity 69 DiHCl;N-(2-Chloroethyl)morpholine HCl
CBNumber: CB4146399
Molecular Formula: C6H13Cl2NO
Formula Weight: 186.08
MOL File: 3647-69-6.mol

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4-(2-Chloroethyl)morpholine hydrochloride Property

Melting point:: 180-185 °C (dec.)(lit.)
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form: Hygroscopic Crystalline Powder
color: White to beige
PH: 4.5-5 (10g/l, H2O, 20℃)
Water Solubility: soluble
Sensitive: Hygroscopic
BRN: 3684083
InChI: InChI=1S/C6H12ClNO.ClH/c7-1-2-8-3-5-9-6-4-8;/h1-6H2;1H
InChIKey: NBJHDLKSWUDGJG-UHFFFAOYSA-N
SMILES: C1OCCN(CCCl)C1.[H]Cl
CAS DataBase Reference: 3647-69-6(CAS DataBase Reference)
EPA Substance Registry System: Morpholine, 4-(2-chloroethyl)-, hydrochloride (3647-69-6)

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Safety

Hazard Codes: T
Risk Statements: 21-25-34-43-52/53
Safety Statements: 26-36/37/39-45-61
RIDADR: UN 2923 8/PG 3
WGK Germany: 2
RTECS: QE0260000
Autoignition Temperature: 365 °C
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29349990
Toxicity: LD50 orally in Rabbit: 96 mg/kg LD50 dermal Rat 1502 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.41417
Product name: N-(2-Chloroethyl)-morpholinium chloride
Purity: for synthesis
Packaging: 100g
Price: $58
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.41417
Product name: N-(2-Chloroethyl)-morpholinium chloride
Purity: for synthesis
Packaging: 10Kg
Price: $1830
Updated: 2025/07/31

Sigma-Aldrich

Product number: C42203
Product name: 4-(2-Chloroethyl)morpholine hydrochloride
Purity: 99%
Packaging: 5G
Price: $32.3
Updated: 2023/06/20

Sigma-Aldrich

Product number: 23051
Product name: 4-(2-Chloroethyl)morpholine hydrochloride
Purity: purum, ≥97.0% (AT)
Packaging: 100g
Price: $50
Updated: 2023/06/20

TCI Chemical

Product number: C1106
Product name: 4-(2-Chloroethyl)morpholine Hydrochloride
Purity: >97.0%(T)
Packaging: 25g
Price: $100
Updated: 2025/07/31

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4-(2-Chloroethyl)morpholine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to beige crystalline powder

Uses

4-(2-Chloroethyl)morpholine hydrochloride (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine). It is also used as Agrochemical Intermediates, dyestuff Intermediates.

Uses

4-(2-Chloroethyl)morpholine is used in the preparation of potential DNA cross-linking antitumor agents as well as synthetic opiate analogues. 4-(2-Chloroethyl)morpholine may possess sickle-cell hemogl obin aggregation inhibiting-activity.

Safety Profile

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

Synthesis

110-91-8

107-07-3

3647-69-6

General procedure for the synthesis of N-(2-chloroethyl)morpholine hydrochloride from morpholine and 2-chloroethanol: 5.0 mL of morpholine (57.5 mmol) and 4.6 mL of 2-chloroethanol (69.0 mmol) were added to 40 mL of toluene, and heated and refluxed for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and then 8.4 mL (114 mmol) of thionyl chloride was added slowly dropwise under ice bath conditions. After the dropwise addition, the reaction was continued in the ice bath for 20 min, after which the ice bath was removed and the reaction mixture was allowed to stir for 6 h at room temperature. At the end of the reaction, toluene and unreacted thionyl chloride were removed by distillation under reduced pressure. The resulting residue was recrystallized from ethanol to give 7.9 g of N-(2-chloroethyl)morpholine hydrochloride.

References

[1] Patent: US2013/85140, 2013, A1. Location in patent: Paragraph 0074; 0075
[2] Patent: CN104710394, 2017, B. Location in patent: Paragraph 0039-0041

4-(2-Chloroethyl)morpholine hydrochloride Preparation Products And Raw materials

Raw materials

2-Morpholinoethanol

Preparation Products

4-(2-MORPHOLIN-4-YL-ETHOXY)-BENZOIC ACID

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4-(2-Chloroethyl)morpholine hydrochloride Suppliers

Americas 1 Belgium 1 Canada 2 China 269 Europe 4 Finland 1 France 4 Germany 7 India 56 Italy 1 Japan 4 Slovakia 1 South Korea 3 Switzerland 7 Ukraine 1 United Kingdom 17 United States 34 Global 413

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TAIYUAN RHF CO.,LTD.

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View Lastest Price from 4-(2-Chloroethyl)morpholine hydrochloride manufacturers

Baoji Guokang Healthchem Co., Ltd.

Product: 4-(2-Chloroethyl)morpholine hydrochloride 3647-69-6
Price: US $242.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1T
Release date: 2021-06-02

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(2-Chloroethyl)morpholine hydrochloride 3647-69-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-07-15

Wuhan Boyuan Import & Export Co., LTD

Product: 4- (2-Chloroethyl) Morphol Ine Hydrochloride 3647-69-6
Price: US $30.00/G
Min. Order: 100G
Purity: 99.9%
Supply Ability: 5000tons
Release date: 2023-07-31

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4-(2-Chloroethyl)morpholine hydrochloride - [C4795]

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3647-69-6

3647-69-4

C6H12NOCI

C6H12ClNOHCl

C6H13Cl2NO

C6H12ClNOClH

C6H13ClNO

Heterocyclic Building Blocks

Halogenated Heterocycles

Morpholines

Building Blocks

Aromatic Morpholines

Building Blocks

C4 to C10

Chemical Synthesis

Halogenated Heterocycles