ChemicalBook > CAS DataBase List > 4-(2-Chloroethyl)morpholine hydrochloride

4-(2-Chloroethyl)morpholine hydrochloride

Product Name
4-(2-Chloroethyl)morpholine hydrochloride
CAS No.
3647-69-6
Chemical Name
4-(2-Chloroethyl)morpholine hydrochloride
Synonyms
MOC;Morpholine, 4-(2-chloroethyl)-, hydrochloride;MOCPRF;4-(2-ChL;ine hydrochL;Chloroethyl Morpholine HCI;Vortioxetine Impurity 70 HCl;2-ChloroethylmorpholineHcl98%;Vortioxetine Impurity 69 DiHCl;N-(2-Chloroethyl)morpholine HCl
CBNumber
CB4146399
Molecular Formula
C6H13Cl2NO
Formula Weight
186.08
MOL File
3647-69-6.mol
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4-(2-Chloroethyl)morpholine hydrochloride Property

Melting point:
180-185 °C (dec.)(lit.)
storage temp. 
Store below +30°C.
solubility 
Chloroform (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form 
Hygroscopic Crystalline Powder
color 
White to beige
PH
4.5-5 (10g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
3684083
InChI
InChI=1S/C6H12ClNO.ClH/c7-1-2-8-3-5-9-6-4-8;/h1-6H2;1H
InChIKey
NBJHDLKSWUDGJG-UHFFFAOYSA-N
SMILES
C1OCCN(CCCl)C1.[H]Cl
CAS DataBase Reference
3647-69-6(CAS DataBase Reference)
EPA Substance Registry System
Morpholine, 4-(2-chloroethyl)-, hydrochloride (3647-69-6)
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Safety

Hazard Codes 
T
Risk Statements 
21-25-34-43-52/53
Safety Statements 
26-36/37/39-45-61
RIDADR 
UN 2923 8/PG 3
WGK Germany 
2
RTECS 
QE0260000
Autoignition Temperature
365 °C
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29349990
Toxicity
LD50 orally in Rabbit: 96 mg/kg LD50 dermal Rat 1502 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.41417
Product name
N-(2-Chloroethyl)-morpholinium chloride
Purity
for synthesis
Packaging
100g
Price
$58
Updated
2025/07/31
Sigma-Aldrich
Product number
8.41417
Product name
N-(2-Chloroethyl)-morpholinium chloride
Purity
for synthesis
Packaging
10Kg
Price
$1830
Updated
2025/07/31
Sigma-Aldrich
Product number
C42203
Product name
4-(2-Chloroethyl)morpholine hydrochloride
Purity
99%
Packaging
5G
Price
$32.3
Updated
2023/06/20
Sigma-Aldrich
Product number
23051
Product name
4-(2-Chloroethyl)morpholine hydrochloride
Purity
purum, ≥97.0% (AT)
Packaging
100g
Price
$50
Updated
2023/06/20
TCI Chemical
Product number
C1106
Product name
4-(2-Chloroethyl)morpholine Hydrochloride
Purity
>97.0%(T)
Packaging
25g
Price
$100
Updated
2025/07/31
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4-(2-Chloroethyl)morpholine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to beige crystalline powder

Uses

4-(2-Chloroethyl)morpholine hydrochloride (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine). It is also used as Agrochemical Intermediates, dyestuff Intermediates.

Uses

4-(2-Chloroethyl)morpholine is used in the preparation of potential DNA cross-linking antitumor agents as well as synthetic opiate analogues. 4-(2-Chloroethyl)morpholine may possess sickle-cell hemogl obin aggregation inhibiting-activity.

Safety Profile

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

Synthesis

110-91-8

107-07-3

3647-69-6

General procedure for the synthesis of N-(2-chloroethyl)morpholine hydrochloride from morpholine and 2-chloroethanol: 5.0 mL of morpholine (57.5 mmol) and 4.6 mL of 2-chloroethanol (69.0 mmol) were added to 40 mL of toluene, and heated and refluxed for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and then 8.4 mL (114 mmol) of thionyl chloride was added slowly dropwise under ice bath conditions. After the dropwise addition, the reaction was continued in the ice bath for 20 min, after which the ice bath was removed and the reaction mixture was allowed to stir for 6 h at room temperature. At the end of the reaction, toluene and unreacted thionyl chloride were removed by distillation under reduced pressure. The resulting residue was recrystallized from ethanol to give 7.9 g of N-(2-chloroethyl)morpholine hydrochloride.

References

[1] Patent: US2013/85140, 2013, A1. Location in patent: Paragraph 0074; 0075
[2] Patent: CN104710394, 2017, B. Location in patent: Paragraph 0039-0041

4-(2-Chloroethyl)morpholine hydrochloride Preparation Products And Raw materials

Raw materials

2-Morpholinoethanol

Preparation Products

4-(2-MORPHOLIN-4-YL-ETHOXY)-BENZOIC ACID
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4-(2-Chloroethyl)morpholine hydrochloride Suppliers

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View Lastest Price from 4-(2-Chloroethyl)morpholine hydrochloride manufacturers

Baoji Guokang Healthchem Co., Ltd.
Product
4-(2-Chloroethyl)morpholine hydrochloride 3647-69-6
Price
US $242.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2021-06-02
Shaanxi Dideu Medichem Co. Ltd
Product
4-(2-Chloroethyl)morpholine hydrochloride 3647-69-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20t
Release date
2024-07-15
Wuhan Boyuan Import & Export Co., LTD
Product
4- (2-Chloroethyl) Morphol Ine Hydrochloride 3647-69-6
Price
US $30.00/G
Min. Order
100G
Purity
99.9%
Supply Ability
5000tons
Release date
2023-07-31

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