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AY 9944

Product Name
AY 9944
CAS No.
366-93-8
Chemical Name
AY 9944
Synonyms
AY 9944;trans-id;AY99442HCl;AY 9944 dihydrochlor;AY 9944 DIHYDROCHLORIDE;AY 9944 - CAS 366-93-8 - Calbiochem;TRANS-1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE, 2HCL;1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE;trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexanedihydrochloride;trans1,4-bis(2-dichlorobenzylaminoethyl)cyclohexanedichlorhydrate
CBNumber
CB3673047
Molecular Formula
C22H30Cl4N2
Formula Weight
464.3
MOL File
366-93-8.mol
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AY 9944 Property

Melting point:
288-293.5 °C(lit.)
storage temp. 
2-8°C
solubility 
DMSO: 14 mg/mL
form 
White solid
color 
white
Water Solubility 
Soluble to 50 mM in water
Sensitive 
Hygroscopic
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Safety

Hazard Codes 
Xi,N
Risk Statements 
36/37/38-50/53
Safety Statements 
26-60-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
RTECS 
GU7025000
HazardClass 
6.1
Toxicity
LD50 orl-mus: 155 mg/kg PSEBAA 139,100,72
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S693162
Product name
1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE
Purity
Aldrich
Packaging
5mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
190080
Product name
AY 9944
Packaging
5mg
Price
$230
Updated
2024/03/01
Alfa Aesar
Product number
J65079
Product name
AY 9944 dihydrochloride
Packaging
50mg
Price
$896
Updated
2023/06/20
Cayman Chemical
Product number
14611
Product name
AY 9944
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
14611
Product name
AY 9944
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
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AY 9944 Chemical Properties,Usage,Production

Uses

Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol 7-reductase and 8,7-sterol isomerase. A sonic hedgehog inhibitor

Uses

Inhibitor of hedgehog (Hh) signaling

Biological Activity

Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ 7 -dehydrocholesterol reductase (IC 50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo .

Safety Profile

Poison by ingestion.Experimental teratogenic and reproductive effects.Inhibits cholesterol synthesis. When heated todecomposition it emits very toxic fumes of NOx and Cl-.

storage

room temperature (desiccate)

References

[1]. moebius, f.f., et al., molecular cloning and expression of the human delta7-sterol reductase. proc natl acad sci u s a, 1998. 95(4): p. 1899-902.
[2]. achour, a., et al., restoration of immune response by a cationic amphiphilic drug (ay 9944) in vitro: a new approach to chemotherapy against human immunodeficiency virus type 1. antimicrob agents chemother, 1998. 42(10): p. 2482-91.
[3]. xu, l., et al., novel oxysterols observed in tissues and fluids of ay9944-treated rats: a model for smith-lemli-opitz syndrome. j lipid res, 2011. 52(10): p. 1810-20.

AY 9944 Preparation Products And Raw materials

Raw materials

Preparation Products

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AY 9944 Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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Jiangsu yize medical technology co. LTD
Tel
18962082606
Email
3394205705@qq.com
Country
China
ProdList
9837
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58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988968278
Fax
QQ:3283937693
Email
sales@ubiochem.com
Country
China
ProdList
4297
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58
Shanghai Puluokai Medical Technology Co., LTD
Tel
17269768198
Fax
QQ:1213744847
Email
prochemx@163.com
Country
China
ProdList
613
Advantage
58

366-93-8, AY 9944Related Search:


  • 1,4-cyclohexanebis(methylamine),n,n’-bis(2-chlorobenzyl)-,dihydrochloride,(e
  • 4-cyclohexanebis(methylamine),n,n’-bis(o-chlorobenzyl)-dihydrochloride
  • 4-cyclohexanedimethanamine,n,n’-bis((2-chlorophenyl)methyl)-dihydrochlor
  • trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexanedihydrochloride
  • N-[(2-chlorophenyl)methyl]-1-[4-[[(2-chlorophenyl)methylamino]methyl]cyclohexyl]methanamine dihydrochloride
  • 1,1'-((1r,4r)-cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine)
  • 1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE
  • AY 9944 - CAS 366-93-8 - Calbiochem
  • AY99442HCl
  • trans-1,4-Bis(2-chlorobenzylaminomethyl)cyclohexane,dihydrochloride
  • N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride
  • trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride
  • trans-1,4-Bis(2-Chlorobenzylamimomethyl)cyclohexane dihydrochloride
  • (2-chlorobenzyl)-[[4-[[(2-chlorobenzyl)amino]methyl]cyclohexyl]methyl]amine dihydrochloride
  • trans1,4-bis(2-dichlorobenzylaminoethyl)cyclohexanedichlorhydrate
  • trans-id
  • trans-n,n’-(1,4-cyclohexylenedimethylene)bis(2-chlorobenzylamine)dihydrochlo
  • trans-n,n’-bis(2-chlorobenzyl)-1,4-cyclohexanebis(methylamine)dihydrochlorid
  • TRANS-N,N-BIS[2-CHLOROPHENYLMETHYL]-1,4-CYCLOHEXANEDIMETHANAMINE DIHYDROCHLORIDE
  • TRANS-1,4-BIS(2-CHLOROBENZYLAMINOETHYL) CYCLOHEXANE DIHYDROCHLORIDE
  • TRANS-1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE, 2HCL
  • AY 9944
  • AY 9944 DIHYDROCHLORIDE
  • AY 9944 dihydrochlor
  • 7DHC,AY 9944,hypocholesterolemia,inhibit,AY-9944,cholesterol,Inhibitor,isomerase,AY9944,Δ7-Δ8,accumulation,reductase,biosynthesis
  • trans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride
  • 366-93-8
  • C22H28Cl2N22HCl
  • C22H30Cl4N2
  • Lipid signaling
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals