AY 9944
- Product Name
- AY 9944
- CAS No.
- 366-93-8
- Chemical Name
- AY 9944
- Synonyms
- AY 9944;trans-id;AY99442HCl;AY 9944 dihydrochlor;AY 9944 DIHYDROCHLORIDE;AY 9944 - CAS 366-93-8 - Calbiochem;TRANS-1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE, 2HCL;1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE;trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexanedihydrochloride;trans1,4-bis(2-dichlorobenzylaminoethyl)cyclohexanedichlorhydrate
- CBNumber
- CB3673047
- Molecular Formula
- C22H30Cl4N2
- Formula Weight
- 464.3
- MOL File
- 366-93-8.mol
AY 9944 Property
- Melting point:
- 288-293.5 °C(lit.)
- storage temp.
- 2-8°C
- solubility
- DMSO: 14 mg/mL
- form
- White solid
- color
- white
- Water Solubility
- Soluble to 50 mM in water
- Sensitive
- Hygroscopic
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 36/37/38-50/53
- Safety Statements
- 26-60-61
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 3
- RTECS
- GU7025000
- HazardClass
- 6.1
- Toxicity
- LD50 orl-mus: 155 mg/kg PSEBAA 139,100,72
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S693162
- Product name
- 1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE
- Purity
- Aldrich
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 190080
- Product name
- AY 9944
- Packaging
- 5mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- J65079
- Product name
- AY 9944 dihydrochloride
- Packaging
- 50mg
- Price
- $896
- Updated
- 2023/06/20
- Product number
- 14611
- Product name
- AY 9944
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 14611
- Product name
- AY 9944
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
AY 9944 Chemical Properties,Usage,Production
Uses
Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol 7-reductase and 8,7-sterol isomerase. A sonic hedgehog inhibitor
Uses
Inhibitor of hedgehog (Hh) signaling
Biological Activity
Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ 7 -dehydrocholesterol reductase (IC 50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo .
Safety Profile
Poison by ingestion.Experimental teratogenic and reproductive effects.Inhibits cholesterol synthesis. When heated todecomposition it emits very toxic fumes of NOx and Cl-.
storage
room temperature (desiccate)
References
[1]. moebius, f.f., et al., molecular cloning and expression of the human delta7-sterol reductase. proc natl acad sci u s a, 1998. 95(4): p. 1899-902.
[2]. achour, a., et al., restoration of immune response by a cationic amphiphilic drug (ay 9944) in vitro: a new approach to chemotherapy against human immunodeficiency virus type 1. antimicrob agents chemother, 1998. 42(10): p. 2482-91.
[3]. xu, l., et al., novel oxysterols observed in tissues and fluids of ay9944-treated rats: a model for smith-lemli-opitz syndrome. j lipid res, 2011. 52(10): p. 1810-20.
AY 9944 Preparation Products And Raw materials
Raw materials
Preparation Products
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