AY 9944

Product Name: AY 9944
CAS No.: 366-93-8
Chemical Name: AY 9944
Synonyms: AY 9944;trans-id;AY99442HCl;AY 9944 dihydrochlor;AY 9944, 10 mM in DMSO;AY 9944 DIHYDROCHLORIDE;AY 9944 - CAS 366-93-8 - Calbiochem;AY 9944 dihydrochloride, Hedgehog signaling inhibitor;TRANS-1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE, 2HCL;1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE
CBNumber: CB3673047
Molecular Formula: C22H30Cl4N2
Formula Weight: 464.3
MOL File: 366-93-8.mol

More

Less

AY 9944 Property

Melting point:: 288-293.5 °C(lit.)
storage temp.: 2-8°C
solubility: DMSO: 14 mg/mL
form: White solid
color: white
Water Solubility: Soluble to 50 mM in water
Sensitive: Hygroscopic

More

Less

Safety

Hazard Codes: Xi,N
Risk Statements: 36/37/38-50/53
Safety Statements: 26-60-61
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: GU7025000
HazardClass: 6.1
Toxicity: LD50 orl-mus: 155 mg/kg PSEBAA 139,100,72

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S693162
Product name: 1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $113
Updated: 2025/07/31

Sigma-Aldrich

Product number: 190080
Product name: AY 9944
Packaging: 5mg
Price: $248
Updated: 2025/07/31

Sigma-Aldrich

Product number: S693162
Product name: 1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE
Purity: Aldrich
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 14611
Product name: AY 9944
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 14611
Product name: AY 9944
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

More

Less

AY 9944 Chemical Properties,Usage,Production

Uses

Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol 7-reductase and 8,7-sterol isomerase. A sonic hedgehog inhibitor

Uses

Inhibitor of hedgehog (Hh) signaling

Biological Activity

Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ 7 -dehydrocholesterol reductase (IC 50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo .

Safety Profile

Poison by ingestion.Experimental teratogenic and reproductive effects.Inhibits cholesterol synthesis. When heated todecomposition it emits very toxic fumes of NOx and Cl-.

in vivo

AY 9944 (7.5 mg/kg; i.h. every 6 days once from postnatal day 2 to postnatal day 20) reduces brain cholesterol until 400 days after stop treatment^[3].

Animal Model:	Long–Evans hooded rats^[3].
Dosage:	7.5 mg/kg
Administration:	Subcutaneous injection; 7.5 mg/kg every 6 days once; from postnatal day 2 to postnatal day 20
Result:	Reduced brain cholesterol and increased 7-dehydrocholesterol in all brain regions of rats till the treatment stopped for 400 days and showed a more severe effect on the change of sterols in plasma and liver of female rats.

storage

room temperature (desiccate)

References

[1]. moebius, f.f., et al., molecular cloning and expression of the human delta7-sterol reductase. proc natl acad sci u s a, 1998. 95(4): p. 1899-902.
[2]. achour, a., et al., restoration of immune response by a cationic amphiphilic drug (ay 9944) in vitro: a new approach to chemotherapy against human immunodeficiency virus type 1. antimicrob agents chemother, 1998. 42(10): p. 2482-91.
[3]. xu, l., et al., novel oxysterols observed in tissues and fluids of ay9944-treated rats: a model for smith-lemli-opitz syndrome. j lipid res, 2011. 52(10): p. 1810-20.

AY 9944 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AY 9944 Suppliers

Canada 1 China 77 Germany 1 Switzerland 1 United Kingdom 2 United States 11 USA 1 Global 94

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Haiji Pharmaceutical Technology (Suzhou) Co., Ltd

Tel: 18012778619
Email: 3394205705@qq.com
Country: China
ProdList: 9844
Advantage: 58

Shanghai Puluokai Medical Technology Co., LTD

Tel: 17269768198
Fax: QQ:1213744847
Email: prochemx@163.com
Country: China
ProdList: 613
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

366-93-8, AY 9944Related Search:

2-Chlorobenzylamine 1,4-Cyclohexanebis(methylamine) AY 9944

1,4-cyclohexanebis(methylamine),n,n’-bis(2-chlorobenzyl)-,dihydrochloride,(e

4-cyclohexanebis(methylamine),n,n’-bis(o-chlorobenzyl)-dihydrochloride

4-cyclohexanedimethanamine,n,n’-bis((2-chlorophenyl)methyl)-dihydrochlor

trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexanedihydrochloride

N-[(2-chlorophenyl)methyl]-1-[4-[[(2-chlorophenyl)methylamino]methyl]cyclohexyl]methanamine dihydrochloride

1,1'-((1r,4r)-cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine)

1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE

AY 9944 - CAS 366-93-8 - Calbiochem

AY99442HCl

trans-1,4-Bis(2-chlorobenzylaminomethyl)cyclohexane,dihydrochloride

N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride

trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride

trans-1,4-Bis(2-Chlorobenzylamimomethyl)cyclohexane dihydrochloride

(2-chlorobenzyl)-[[4-[[(2-chlorobenzyl)amino]methyl]cyclohexyl]methyl]amine dihydrochloride

trans1,4-bis(2-dichlorobenzylaminoethyl)cyclohexanedichlorhydrate

trans-id

trans-n,n’-(1,4-cyclohexylenedimethylene)bis(2-chlorobenzylamine)dihydrochlo

trans-n,n’-bis(2-chlorobenzyl)-1,4-cyclohexanebis(methylamine)dihydrochlorid

TRANS-N,N-BIS[2-CHLOROPHENYLMETHYL]-1,4-CYCLOHEXANEDIMETHANAMINE DIHYDROCHLORIDE

TRANS-1,4-BIS(2-CHLOROBENZYLAMINOETHYL) CYCLOHEXANE DIHYDROCHLORIDE

TRANS-1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE, 2HCL

AY 9944

AY 9944 DIHYDROCHLORIDE

AY 9944 dihydrochlor

7DHC,AY 9944,hypocholesterolemia,inhibit,AY-9944,cholesterol,Inhibitor,isomerase,AY9944,Δ7-Δ8,accumulation,reductase,biosynthesis

trans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride

AY 9944 dihydrochloride, Hedgehog signaling inhibitor

AY 9944, 10 mM in DMSO

trans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride , AY 9944

trans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride

366-93-8

C22H28Cl2N22HCl

C22H30Cl4N2

Lipid signaling

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals