ChemicalBook > CAS DataBase List > N,N-DIETHYLNICOTINAMIDE

N,N-DIETHYLNICOTINAMIDE

Product Name: N,N-DIETHYLNICOTINAMIDE
CAS No.: 59-26-7
Chemical Name: N,N-DIETHYLNICOTINAMIDE
Synonyms: NIKETHAMIDE;Nikotin;CORVOTONE;Tonocard;nicor;Ni-Cor;Corivo;Cormed;Cormid;Corvin
CBNumber: CB3677171
Molecular Formula: C10H14N2O
Formula Weight: 178.23
MOL File: 59-26-7.mol

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N,N-DIETHYLNICOTINAMIDE Property

Melting point:: 23 °C (lit.)
Boiling point:: 296-300 °C (lit.)
Density: 1.06 g/mL at 25 °C (lit.)
refractive index: n20/D 1.524(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: pKa 3.46(H2O,t =20) (Uncertain)
form: Liquid
color: Clear colorless to yellow
Merck: 14,6543
BRN: 5743
InChI: InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
InChIKey: NCYVXEGFNDZQCU-UHFFFAOYSA-N
SMILES: C1=NC=CC=C1C(N(CC)CC)=O
CAS DataBase Reference: 59-26-7(CAS DataBase Reference)
EPA Substance Registry System: Nikethamide (59-26-7)

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38-23/24/25
Safety Statements: 26-45-36/37/39
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: QS4375000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29333999
Toxicity: LD50 i.p. in rats: 272 mg/kg (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D98807
Product name: N,N-Diethylnicotinamide
Purity: 99%
Packaging: 25g
Price: $64.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: N0800000
Product name: Nikethamide
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 1 mL
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: D98807
Product name: N,N-Diethylnicotinamide
Purity: 99%
Packaging: 100g
Price: $128
Updated: 2023/06/20

Sigma-Aldrich

Product number: D98807
Product name: N,N-Diethylnicotinamide
Purity: 99%
Packaging: 500g
Price: $181
Updated: 2025/07/31

Sigma-Aldrich

Product number: N0800000
Product name: Nikethamide
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: n0800000
Price: $220
Updated: 2024/03/01

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N,N-DIETHYLNICOTINAMIDE Chemical Properties,Usage,Production

Description

A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca M. Pop. It forms colourless needles from EtOH and is optically active with a specific rotation of [α]_D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p. 216-9°C and the hydrobromide, m.p. 223-6°C have been described.

Chemical Properties

clear colorless to yellow liquid

Uses

analeptic

Uses

N,N-Diethylnicotinamide (DENC) is commonly used as a ligand to prepare tetranuclear copper complexes.

Definition

ChEBI: Nikethamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.

Application

N,N-Diethylnicotinamide (DENA) is one of the central respiratory stimulants and is used in the study of respiratory failure. DENA is also an excellent hydrophilic agent for paclitaxel (PTX) and improves the water solubility of PTX.

General Description

Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth.

Air & Water Reactions

Water soluble.

Reactivity Profile

N,N-DIETHYLNICOTINAMIDE is incompatible with sodium carbonate solutions which cause precipitation. .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition N,N-DIETHYLNICOTINAMIDE emits toxic fumes.

Fire Hazard

N,N-DIETHYLNICOTINAMIDE is combustible.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.

References

Yunusov, Akramov, Yunusov, Dokl. Akad. Nauk. USSR, 162,607 (1965)
Yunusov, Akramov, Yunusov, Khim. Prir. Soedin., 2, 340 (1966)
Ibragimova, Yunusov, Yunusov, ibid, 6,438 (1970)
Yunusov, et al., ibid, 7, 380 (1971)

N,N-DIETHYLNICOTINAMIDE Preparation Products And Raw materials

Raw materials

Nicotinic acid Diethylamine

Preparation Products

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N,N-DIETHYLNICOTINAMIDE Suppliers

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View Lastest Price from N,N-DIETHYLNICOTINAMIDE manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: N,N-DIETHYLNICOTINAMIDE 59-26-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-30

Hebei Chuanghai Biotechnology Co., Ltd

Product: N,N-DIETHYLNICOTINAMIDE 59-26-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

Henan Suikang Pharmaceutical Co.,Ltd.

Product: N,N-DIETHYLNICOTINAMIDE 59-26-7
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99.0%
Supply Ability: 1tons
Release date: 2024-04-28

59-26-7, N,N-DIETHYLNICOTINAMIDERelated Search:

4-[(2-CHLOROPYRIDIN-3-YL)CARBONYL]MORPHOLINE N,N-DIETHYLNICOTINAMIDE nicopholine Nicotinamide N,N-DIISOPROPYLNICOTINAMIDE 1-Nicotinoyl-4-phenyl-2-pyrrolidinone N-BENZYL-N-NICOTINOYLNICOTINAMIDE N,N-Diethylnicotinamide 1-oxide (2-CHLORO-3-PYRIDINYL)(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)METHANONE [4-(4-CHLOROPHENYL)-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDIN-5-YL](2-CHLORO-3-PYRIDYL)METHANONE 3-PYRIDYL 4-(5-(TRIFLUOROMETHYL)(2-PYRIDYL))PIPERAZINYL KETONE N3-BENZYL-N3-(2-THIENYLMETHYL)-2-CHLORONICOTINAMIDE (4-METHYLPIPERAZINO)[6-(1H-PYRAZOL-1-YL)-3-PYRIDINYL]METHANONE 1-(PYRIDIN-3-YLCARBONYL)PIPERIDINE-4-CARBOXYLIC ACID MORPHOLINO[6-(1H-PYRAZOL-1-YL)-3-PYRIDINYL]METHANONE [(2-(TRIFLUOROMETHYL)-1,6-NAPHTHYRIDIN-3-YL)CARBONYL]PYRROLIDINE 7-CHLORO-N,N-DIETHYL-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE (2-METHYL-1,6-NAPHTHYRIDIN-3-YL)MORPHOLINOMETHANONE

CORVOTONE

DYNACORYL

EUCORAN

LABOTEST-BB LT00134638

PYRIDINE-3-CARBOXYLIC ACID DIETHYLAMIDE

PYRICARDYL

N,N-DIETHYLNICOTINAMIDE

NICKETHAMIDE

NICOTINIC ACID DIETHYLAMIDE

NIKETHAMIDE

NIKETHAMIDUM

NICAMIDE

3-Pyridinecarboxamide, N,N-diethyl-

Anacordone

Astrocar

beta-Pyrimidum

Camphozone

Canfodiamina

Carbamidal

Cardamine

Cardiagen

Hansacor

Inicardio

Kardiamid

Kardonyl

Kordiamin

Leptamin

Mediamid

N,N-Diethyl-3-pyridinecarboxamide

N,N-Diethyl-3-pyri-dinecarboxamide

n,n-diethyl-nicotinamid

Niamine

Nicetamide

nicethamid

Nicethamide

nicor

Ni-Cor

Nicordamin

Nicorine

Nicoryl

Nicotinamide, N,N-diethyl-

Nikardin

N,N-Diethylnicotinamide (Nikethamide)

N,N-Diethylnicotinamide,97%

N,N-Diethylnicotinamide 59-26-7

Phenyl 2-hydroxy-4,5-dimethoxybenzoate CORVOTONE

ANACARDONE

Cardiamid

Cardiamide

Cardiamina

Cardiamine

Cardimon

Citocor

Coracon

Coractiv N

Coraetamidum

Coraethamide

Coraethamidum