P1075

Product Name: P1075
CAS No.: 60559-98-0
Chemical Name: P1075
Synonyms: P1075;-3-pyridinyl-guanidine;-(1,1-dimethylpropyl)-N’2-cyano-1-tert-pentyl-3-(3-pyridyl)guanidine;2-cyano-1-tert-pentyl-3-(3-pyridyl)-guanidin;N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-3-PYRIDYLGUANIDINE;n-cyano-n’-(1,1-dimethylpropyl)-n’’-3-pyridinyl-guanidin;N-cyano-N'-(1,1-dimethylpropyl)-N''-(3-pyridinyl)guanidine;Guanidine, N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-;Inhibitor,Potassium Channel,P1075,KcsA,COS-7,adult rabbit cardiomyocytes,inhibit,P 1075,P-1075
CBNumber: CB3682098
Molecular Formula: C12H17N5
Formula Weight: 231.3
MOL File: 60559-98-0.mol

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P1075 Property

Melting point:: 186-187 °C
Boiling point:: 347.6±34.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 50 mM in ethanol and to 100 mM in DMSO
form: Powder
pka: 4.74±0.11(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21849
Product name: P1075
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 21849
Product name: P1075
Purity: ≥98%
Packaging: 5mg
Price: $179
Updated: 2024/03/01

Tocris

Product number: 1355
Product name: P1075
Purity: ≥99%(HPLC)
Packaging: 10
Price: $210
Updated: 2021/12/16

Tocris

Product number: 1355
Product name: P1075
Purity: ≥99%(HPLC)
Packaging: 50
Price: $882
Updated: 2021/12/16

Usbiological

Product number: 256142
Product name: P1075
Packaging: 10mg
Price: $466
Updated: 2021/12/16

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P1075 Chemical Properties,Usage,Production

Uses

N-Cyano-N''-(1,1-dimethylpropyl)-N''''-3-pyridinyl-guanidine is an ATP-sensitive potassium channels activator or opener (KATPCO) by causing relaxation of various isolated animal and human blood vessels.

Definition

ChEBI: 1-cyano-2-(2-methylbutan-2-yl)-3-(3-pyridinyl)guanidine is a member of pyridines.

Biological Activity

Potent K ATP channel opener (EC 50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (K d values are 17 and 3 nM respectively).

Enzyme inhibitor

This potent potassium ion channel opener, or KCO (FW = 231.30 g/mol; CAS 60559-98-0; Solubility: 50 mM in Ethanol; 100 mM in DMSO), also known as N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridyl-guanidine, targets Kir6 (or KATP) channels (EC50 = 7.5 nM; for relaxation of rat aorta). In studies on rats, rabbit and dogs, P1075 effects only correlate with the presence of specific receptor binding sites in rat vascular preparations, showing there are significant species-specific and raising questions about the pharmacological significance of this KATP opener binding site. These channels are heteromultimers composed with a 4:4 stoichiometry of an inwardly rectifying K+ channel subunit plus a regulatory subunit comprising the receptor sites for hypoglycemic sulfonylureas and KCOs (a sulfonylurea receptor). P1075-induced channel activation IS mediated by drug interaction with a single binding site per tetradimeric complex. P-1075 also binds to sulfonylurea receptors SUR2A (Kd = 17 nM) and SUR2B (Kd = 3 nM)

P1075 Preparation Products And Raw materials

Raw materials

Preparation Products

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P1075 Suppliers

China 30 Germany 2 India 1 South Korea 1 United Kingdom 2 United States 8 USA 1 Global 45

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60559-98-0, P1075Related Search:

Dicyandiamide [3H]P-1075 P1075

P1075

N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-3-PYRIDYLGUANIDINE

2-cyano-1-tert-pentyl-3-(3-pyridyl)-guanidin

2-cyano-1-tert-pentyl-3-(3-pyridyl)guanidine

n-cyano-n’-(1,1-dimethylpropyl)-n’’-3-pyridinyl-guanidin

N-cyano-N'-(1,1-dimethylpropyl)-N''-(3-pyridinyl)guanidine

Guanidine, N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-

-(1,1-dimethylpropyl)-N&rsquo

-3-pyridinyl-guanidine

Inhibitor,Potassium Channel,P1075,KcsA,COS-7,adult rabbit cardiomyocytes,inhibit,P 1075,P-1075

60559-98-0

C12H17N5

Potassium channel