P1075
- Product Name
- P1075
- CAS No.
- 60559-98-0
- Chemical Name
- P1075
- Synonyms
- P1075;-3-pyridinyl-guanidine;-(1,1-dimethylpropyl)-N’2-cyano-1-tert-pentyl-3-(3-pyridyl)guanidine;2-cyano-1-tert-pentyl-3-(3-pyridyl)-guanidin;N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-3-PYRIDYLGUANIDINE;n-cyano-n’-(1,1-dimethylpropyl)-n’’-3-pyridinyl-guanidin;N-cyano-N'-(1,1-dimethylpropyl)-N''-(3-pyridinyl)guanidine;Guanidine, N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-;Inhibitor,Potassium Channel,P1075,KcsA,COS-7,adult rabbit cardiomyocytes,inhibit,P 1075,P-1075
- CBNumber
- CB3682098
- Molecular Formula
- C12H17N5
- Formula Weight
- 231.3
- MOL File
- 60559-98-0.mol
P1075 Property
- Melting point:
- 186-187 °C
- Boiling point:
- 347.6±34.0 °C(Predicted)
- Density
- 1.07±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 50 mM in ethanol and to 100 mM in DMSO
- form
- Powder
- pka
- 4.74±0.11(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21849
- Product name
- P1075
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 21849
- Product name
- P1075
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 1355
- Product name
- P1075
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $210
- Updated
- 2021/12/16
- Product number
- 1355
- Product name
- P1075
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $882
- Updated
- 2021/12/16
- Product number
- 256142
- Product name
- P1075
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
P1075 Chemical Properties,Usage,Production
Uses
N-Cyano-N''-(1,1-dimethylpropyl)-N''''-3-pyridinyl-guanidine is an ATP-sensitive potassium channels activator or opener (KATPCO) by causing relaxation of various isolated animal and human blood vessels.
Definition
ChEBI: 1-cyano-2-(2-methylbutan-2-yl)-3-(3-pyridinyl)guanidine is a member of pyridines.
Biological Activity
Potent K ATP channel opener (EC 50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (K d values are 17 and 3 nM respectively).
Enzyme inhibitor
This potent potassium ion channel opener, or KCO (FW = 231.30 g/mol; CAS 60559-98-0; Solubility: 50 mM in Ethanol; 100 mM in DMSO), also known as N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridyl-guanidine, targets Kir6 (or KATP) channels (EC50 = 7.5 nM; for relaxation of rat aorta). In studies on rats, rabbit and dogs, P1075 effects only correlate with the presence of specific receptor binding sites in rat vascular preparations, showing there are significant species-specific and raising questions about the pharmacological significance of this KATP opener binding site. These channels are heteromultimers composed with a 4:4 stoichiometry of an inwardly rectifying K+ channel subunit plus a regulatory subunit comprising the receptor sites for hypoglycemic sulfonylureas and KCOs (a sulfonylurea receptor). P1075-induced channel activation IS mediated by drug interaction with a single binding site per tetradimeric complex. P-1075 also binds to sulfonylurea receptors SUR2A (Kd = 17 nM) and SUR2B (Kd = 3 nM)