Background and overview Pharmacological effects Pharmacokinetics Indications Adverse reactions Medicine interactions Precautions Contraindication Elderly patients medication
ChemicalBook > CAS DataBase List > Ranitidine Hydrochloride

Ranitidine Hydrochloride

Background and overview Pharmacological effects Pharmacokinetics Indications Adverse reactions Medicine interactions Precautions Contraindication Elderly patients medication
Product Name
Ranitidine Hydrochloride
CAS No.
66357-59-3
Chemical Name
Ranitidine Hydrochloride
Synonyms
Zamec;ZANTAC;Melfax;Zintac;noctone;ranidil;ah19065;NoCLone;Azantac;Raniben
CBNumber
CB3685534
Molecular Formula
C13H23ClN4O3S
Formula Weight
350.86
MOL File
66357-59-3.mol
More
Less

Ranitidine Hydrochloride Property

Melting point:
134°C (dec.)
storage temp. 
2-8°C
solubility 
H2O: 1.8 mg/mL
form 
solid
color 
tan
Water Solubility 
Soluble in water, 2-hydroxypropyl-beta-cyclodextrin, acetic acid, methanol, ethanol and dimethyl sulfoxide. Insoluble in chloroform.
Sensitive 
Hygroscopic
Merck 
14,8110
CAS DataBase Reference
66357-59-3(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
F,T
Risk Statements 
20/21/22-39/23/24/25-23/24/25-11
Safety Statements 
22-24/25-45-36/37-16-7
WGK Germany 
2
RTECS 
KM6557000
HS Code 
2932190002
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1026
Product name
Ranitidine hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$84.5
Updated
2020/08/18
Sigma-Aldrich
Product number
Y0001787
Product name
Ranitidine for impurity A identification
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1598405
Product name
Ranitidine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$366
Updated
2020/08/18
TCI Chemical
Product number
R0073
Product name
Ranitidine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$62
Updated
2021/03/22
TCI Chemical
Product number
R0073
Product name
Ranitidine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$163
Updated
2021/03/22
More
Less

Ranitidine Hydrochloride Chemical Properties,Usage,Production

Background and overview

Ranitidine Hydrochloride (RHCl) is a kind of histamine H2 receptor antagonist. Since its listing in 1981, ranitidine hydrochloride has been widely used in nearly one hundred countries in the world, including China. It is clinically used for the treatment of duodenal ulcer, reflux esophagitis and Zollinger-Ellison syndrome. It is also used for the prevention of gastrointestinal bleeding caused by stress ulcer and recurrent hemorrhage of peptic ulcer. In recent decade, through the combination of ranitidine and other drugs, it has found that it has high efficiency and remarkable features in the treatment of Helicobacter pylori-positive duodenal ulcer, urticaria and post-cerebral hemorrhage stress ulcer with better efficacy than other similar drugs. Owing to its rapid effect, good potency and low price, ranitidine hydrochloride plays an important role in the anti-ulcer drug market today. Therefore, strict quality control plays important roles in guiding patients with reasonable, safe medication.

Pharmacological effects

This product is a H2 receptor inhibitor, being capable of inhibiting the gastric acid secretion. After oral administration, it is absorbed through the gastrointestinal tract quickly. Synthetic route [4]
The intermediates (3) and (5) were synthesized as follows. The intermediates (3) and (5) were then reacted to produce (6) ranitidine. The (6) is subject to purification and salt formation to generate ranitidine hydrochloride, as shown:

Pharmacokinetics

After oral administration, it is absorbed rapidly from the gastrointestinal tract with a bioavailability (F) of about 50% and peak plasma concentration (tmax) reaching within 1 to 2 hours. Plasma protein binding rate is 15% ± 3%; effective blood concentration is 100ng / ml, widely distributed in the body with the apparent volume of distribution (Vd) of 1.1 ~ 1.9L / Kg. It can penetrate through the blood brain barrier with the drug concentration in cerebrospinal fluid being 1/30 ~ 1 / 20 of blood concentration. 30% is subject to liver metabolism with the metabolites including N-oxide, S-oxide and demethylation metabolites. 50% of the prototype is subject to urine excretion through kidney. Half-life (t1 / 2) is 2 to 3 hours, which is similar to cimetidine. Renal failure causes corresponding increase in the half-life. The goods can be transplanted via the placenta with the milk concentration being higher than the plasma concentration of drugs.

Indications

For the treatment of duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome and other high acid secretion disorders.

Adverse reactions

  • Common reactions are: nausea, rash, constipation, fatigue, headache, dizziness and so on.
  • Light adverse reactions on the renal function, gonadal function and central nervous system.
  • A small number of patients get mild liver damage after taking the drug with the symptoms disappearing after stopping, liver function returned to normal.

Medicine interactions

  • Combination with procainamide reduces the clearance rate of the later one.
  • Drug interactions may occur if used with other medications, consult physician or pharmacist for details.

Precautions

  • This product mustn’t be used continuously for more than 7 days, the symptom is not relieved, consult your physician or pharmacist.
  • Elderly patients or patients with liver and kidney dysfunction use with caution.
  • If overdose or serious adverse reactions, should seek medical treatment immediately.
  • Disable it for people who are allergic to this product; allergies should use with caution.
  • This product is not allowed for administration upon change of its traits.
  • Please put this product where children cannot touch.
  • Children must be under adult guardianship. 
  • If you are using other drugs, please consult your physician or pharmacist before using this product.

Contraindication

  • Children under 8 years should be disabled.
  • Pregnant and lactating women should be disabled.

Elderly patients medication

The elderly have reduced liver and kidney function; in order to ensure drug safety, dosage should be adjusted.

Chemical Properties

Off-White Crystalline Solid

Uses

A histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.

Uses

antifungal

brand name

Zantac (GlaxoSmithKline).

Contact allergens

Ranitidine, an H2-receptor antagonist, can cause contact dermatitis within the pharmaceutical industry and in health care workers, or may induce systemic drug reactions in patients.

Ranitidine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ranitidine Hydrochloride Suppliers

Suzhou Philip Johnson Pharmaceutical Co., Ltd
Tel
--
Fax
--
Email
wangchunhua@homesunpharm.com
Country
China
ProdList
57
Advantage
50
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12356
Advantage
60
Adamas Reagent, Ltd.
Tel
400-600-9262
Email
bxy@titansci.com
Country
China
ProdList
13915
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8940
Advantage
52
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
Advantage
57
More
Less

View Lastest Price from Ranitidine Hydrochloride manufacturers

Hebei Crovell Biotech Co Ltd
Product
Ranitidine Hydrochloride 66357-59-3
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-07-06
Hebei Lingding Biological Technology Co., Ltd
Product
Ranitidine HCL 66357-59-3
Price
US $90.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-05-24
Dideu Industries Group Limited
Product
Ranitidine Hydrochloride USP/EP/BP 66357-59-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-03

66357-59-3, Ranitidine HydrochlorideRelated Search:


  • ah19065
  • ranidil
  • ranigast
  • Ranitidine hydrochloride USP24
  • NoCLone
  • Ranitidine Hydrochlooride
  • (Z)-N-(2-(((5-((dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N-methyl-2-nitroethene-1,1-diamine
  • Ranitidine Hydrochloride, 98.0%(LC&T
  • N'-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2-nitro-1,1-ethenediamine,hydrochloride (1:1)
  • (Ranitidine HCl )CP2005 USp29
  • noctone
  • RANITIDINE HCL
  • n'-[2-[[5-(dimethylaminomethyl)-2-furyl]methylsulfanyl]ethyl]-n-methyl-2-nitro-ethene-1,1-diamine hydrochloride
  • N-[2-[5-[(DIMETHYLAMINO)METHYL]FURFURYLTHIO]ETHYL]-N'-METHYL-2-NITRO-1,1-ETHENEDIAMINE HYDROCHLORIDE
  • n-[2-[[5-[(dimethylamino)methyl]furfuryl]thio]ethyl]-n'-methyl-2-nitrovinylidenediamine hydrochloride
  • n-[2-[[5-[(dimethylamino)methyl]furfuryl]thio]ethyl]-n'-methyl-2-nitrovinylidenediamine monohydrochloride
  • N-[2-[[[5-[(DIMETHYLAMINO)METHYL]-2-FURANYL]METHYL]THIO]ETHYL]-N'-METHYL-2-NITRO-1,1-ETHANEDIAMINE HYDROCHLORIDE
  • N-[2-[[[-5-[(DIMETHYLAMINO)METHYL]-2-FURANYL]METHYL]THIO]ETHYL]-N'-METHYL-2-NITRO-1,1 ETHENEDIAMINE, HYDROCHLORIDE
  • ZANTAC
  • N-[2-[[[5-[(Dimethylamino)methyl]furan-2-yl]methyl]sulfanyl]ethyl]-N′-methyl-2-nitroeth-1-ene-1,1-diamine hydrochloride
  • 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-, hydrochloride
  • Ranitidine for impurity A identification
  • Rantidine hydrochloride USP24
  • Ranitidine hydrochloride CP2000,USP24
  • Rantidine HCL
  • Ranitidine HCL BP2000/USP25
  • RANITIDINE HCL USP (FORM 1)
  • RANITIDINE HCL USP (FORM 2)
  • RANITIDINE HYDROCHLORIDE HISTAMINE H2 RE CEPTOR
  • Ranitidinehydrochloride,99%
  • Zantac[R]
  • N-[2-[[[-5-[(Dimethylamino)methyl)]-2-furanyl]methyl]thio]ethyl]-Nmethyl-2-nitro-1,1ethenediamine, Hydrochloride
  • 1,1-Ethenediamine, N-2-5-(dimethylamino)methyl-2-furanylmethylthioethyl-N-methyl-2-nitro-, monohydrochloride
  • RANITIDINEHYDROCHLORIDE,USP
  • N'-[2-[[5-(dimethylaminomethyl)-2-furyl]methylsulfanyl]ethyl]-N-methyl-2-nitro-ethene-1,1-diamine
  • Azantac
  • Melfax
  • Raniben
  • Raniplex
  • Zintac
  • Ceototac
  • Tsurudek
  • Zamec
  • Ranitidine Hydrochloride (200 mg)
  • N1-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)sulfanyl]ethyl}-N1-methyl-2-nitro-1,1-ethylenediamine hydrochloride
  • Ranitidine HCI
  • Ranitidine hydrochloride CRS
  • Ranitidine Hydrochloride &gt
  • Ranitidine Hydrochloride RS
  • Ranitidine hydrochloride salt
  • Ranitidine for impurity A identification CRS
  • N-(2-(((5-((dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N-methyl-2-nitroethene-1,1-diamine hydrochloride
  • Ranitidine Hydrochloride USP/EP/BP
  • Ranitidine hydrochloride
  • Ranitidine hydrochloride
  • 66357-59-3
  • 66357-35-3
  • 66357-45-5