ChemicalBook > CAS DataBase List > THR-ARG-SER-ALA-TRP

THR-ARG-SER-ALA-TRP

Product Name: THR-ARG-SER-ALA-TRP
CAS No.: 138949-73-2
Chemical Name: THR-ARG-SER-ALA-TRP
Synonyms: Osteostain;OSTEOSTATIN;PTHRP (107-111);THR-ARG-SER-ALA-TRP;OSTEOSTATIN (HUMAN, RAT);H-THR-ARG-SER-ALA-TRP-OH;PTH-RP (107-111) (HUMAN, RAT);PTH RELATED PEPTIDE (107-111);THR-ARG-SER-ALA-TRP USP/EP/BP;PTH-RELATED PROTEIN (107-111) (HUMAN, RAT)
CBNumber: CB3689855
Molecular Formula: C27H41N9O8
Formula Weight: 619.67
MOL File: 138949-73-2.mol

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THR-ARG-SER-ALA-TRP Property

storage temp.: -15°C
form: Solid
Sequence: Thr-Arg-Ser-Ala-Trp

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: O8070-01
Product name: Osteostatin
Packaging: 1mg
Price: $531
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PRO0000428
Product name: THR-ARG-SER-ALA-TRP
Purity: 95.00%
Packaging: 1MG
Price: $617.93
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb372627
Product name: Osteostatin
Purity: > 95%
Packaging: 1mg
Price: $651.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb372627
Product name: Osteostatin
Purity: > 95%
Packaging: 5mg
Price: $1611.6
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb372627
Product name: Osteostatin
Purity: > 95%
Packaging: 10mg
Price: $2410.6
Updated: 2021/12/16

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THR-ARG-SER-ALA-TRP Chemical Properties,Usage,Production

Uses

Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].

in vivo

Osteostatin (80 or 120 μg/kg,; after the onset of disease s.c. every day for 13 days) decreases the severity of arthritis as well as cartilage and bone degradation^[4].

Animal Model:	Collagen-induced arthritis in male DBA/1 mice^[4]
Dosage:	80 or 120 μg/kg
Administration:	After the onset of disease s.c. every day for 13 days
Result:	Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes. Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10.

References

[1] Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6. DOI:10.1210/endo-129-6-3424
[2] Ibá?ez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. DOI:10.3390/ijms23158551
[3] Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803. DOI:10.1016/j.actbio.2009.08.033
[4] Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845. DOI:10.3390/ijms20163845

THR-ARG-SER-ALA-TRP Preparation Products And Raw materials

Raw materials

Preparation Products

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THR-ARG-SER-ALA-TRP Suppliers

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138949-73-2, THR-ARG-SER-ALA-TRPRelated Search:

HEMOGLOBIN Ferritin RP107 THR-ARG-SER-ALA-TRP-NH2,H-THR-ARG-SER-ALA-TRP-NH2 AC-GLY-TRP-OH THR-ARG-SER-ALA-TRP H-GLY-GLY-TRP-OH (Ser(POH)3·)-Tau Peptide (379-408) Acetyl Gastric Inhibitory Peptide (human) CDK2/CYCLIN INHIBITORY PEPTIDE I

OSTEOSTATIN (1-5) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT)

OSTEOSTATIN (HUMAN, RAT)

PARATHYROID HORMONE-RELATED PROTEIN (107-111)

PARATHYROID HORMONE RELATED PROTEIN (107-111), HUMAN, RAT

PARATHYROID HORMONE RELATED PEPTIDE (107-111)

LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE: KHLNSMERVEWLRKKLQDVHNF

pTH-Related Protein (107-111) (huMan, bovine, dog, horse, Mouse, rabbit, rat), HypercalceMia of Malignancy Factor (107-111) (huMan, bovine, dog, horse, Mouse, rabbit, rat), pTH-rP (107-111) (huMan, bovine, dog, horse, Mouse, rabbit, rat)

Osteostatin, Parathyroid hormone-related protein (107-111), PTHrP (107-111), Thr-Arg-Ser-Ala-Trp

Osteostain

HYPERCALCEMIA OF MALIGNANCY FACTOR (107-111) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT)

HYPERCALCEMIA OF MALIGNANCY FACTOR (107-111) (HUMAN, RAT)

HYPERCALCEMIA OF MALIGNANCY FACTOR FRAGMENT 107-111

H-THR-ARG-SER-ALA-TRP-OH

THR-ARG-SER-ALA-TRP

PTHRP (107-111)

PTH-RP (107-111) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT)

PTH-RP (107-111) (HUMAN, RAT)

PTH RELATED PEPTIDE (107-111)

PTH-RELATED PROTEIN (107-111) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT)

PTH-RELATED PROTEIN (107-111) (HUMAN, RAT)

OSTEOSTATIN

L-Tryptophan, L-threonyl-L-arginyl-L-seryl-L-alanyl-

THR-ARG-SER-ALA-TRP USP/EP/BP

Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt H-Thr-Arg-Ser-Ala-Trp-OH trifluoroacetate salt

138949-73-2

C27H41N9O8