ChemicalBook > CAS DataBase List > 2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE
2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE
Uses- Product Name
- 2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE
- CAS No.
- 98026-88-1
- Chemical Name
- 2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE
- Synonyms
- 2-chloro-5-pyrimidinesulfonyl chloride;2-Chloro-pyrimidine-5-sulphonylchloride;2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE;5-PyriMidinesulfonyl chloride, 2-chloro-
- CBNumber
- CB3690224
- Molecular Formula
- C4H2Cl2N2O2S
- Formula Weight
- 213.04
- MOL File
- 98026-88-1.mol
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2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE Property
- Melting point:
- 66-67 °C
- Boiling point:
- 383.2±15.0 °C(Predicted)
- Density
- 1.711±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- pka
- -5.59±0.22(Predicted)
- form
- Crystalline Powder or Powder
- color
- White to cream
- InChI
- InChI=1S/C4H2Cl2N2O2S/c5-4-7-1-3(2-8-4)11(6,9)10/h1-2H
- InChIKey
- DMAOAJYJIATWJS-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(S(Cl)(=O)=O)C=N1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H332Harmful if inhaled
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
TRC
- Product number
- B406408
- Product name
- 2-chloropyrimidine-5-sulfonylchloride
- Packaging
- 5g
- Price
- $520
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC74941
- Product name
- 2-Chloro-5-pyrimidinesulfonyl chloride
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC74941
- Product name
- 2-Chloro-5-pyrimidinesulfonyl chloride
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR346309
- Product name
- 2-Chloro-pyrimidine-5-sulphonylchloride
- Packaging
- 1g
- Price
- $243
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 8H62-5-47
- Product name
- 2-Chloropyrimidine-5-sulfonyl chloride
- Packaging
- 1g
- Price
- $268
- Updated
- 2021/12/16
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2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE Chemical Properties,Usage,Production
Uses
2-Chloro-pyrimidine-5-sulfonyl chloride is a pyrimidine heterocyclic compound mainly used in organic synthesis and pharmaceutical research and development.
Synthesis
40828-51-1
98026-88-1
The general procedure for synthesizing 2-chloropyrimidine-5-sulfonyl chloride using 2-hydroxypyrimidine-5-sulfonic acid as a starting material was as follows: referring to the method of Example 26, 2-hydroxypyrimidine-5-sulfonic acid (12.8 g) was mixed with phosphorus pentachloride (37.8 g) and the reaction was stirred for 4 hrs at 180°C. Upon completion of the reaction, the mixture was cooled to room temperature and toluene (200 mL) was added to dissolve the product, followed by filtration to remove insoluble impurities. The filtrate was washed with ice water and dried over anhydrous magnesium sulfate. After removal of the solvent by evaporation under reduced pressure, the residue was allowed to stand in a refrigerator for one day to give 2-chloropyrimidine-5-sulfonyl chloride in the form of a light yellow solid (yield 14.8 g, 96% yield). The product was characterized by 1H-NMR (CDCl3) with chemical shift δ: 9.19 (2H, s).
References
[1] Patent: US2007/60623, 2007, A1. Location in patent: Page/Page column 23
[2] Patent: WO2006/36024, 2006, A1. Location in patent: Page/Page column 159
[3] Patent: EP2336107, 2015, B1. Location in patent: Paragraph 0303
[4] Patent: WO2004/74283, 2004, A1. Location in patent: Page 87
[5] Patent: EP1803709, 2007, A1
2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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