1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL
- Product Name
- 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL
- CAS No.
- 488-41-5
- Chemical Name
- 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL
- Synonyms
- r54;myebrol;nsc-94100;NSC 94110;mieobromol;nci-c04762;dibromannit;myelobromol;Mielobromol;mitobronitol
- CBNumber
- CB3692682
- Molecular Formula
- C6H12Br2O4
- Formula Weight
- 307.97
- MOL File
- 488-41-5.mol
1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL Property
- Melting point:
- 176-178°
- Boiling point:
- 511.2±50.0 °C(Predicted)
- Density
- 1.8987 (rough estimate)
- refractive index
- 1.4840 (estimate)
- storage temp.
- −20°C
- pka
- 12.61±0.20(Predicted)
- EPA Substance Registry System
- Mitobronitol (488-41-5)
Safety
- Hazard Codes
- T
- Risk Statements
- 45-22
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- RTECS
- OP2800000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H350May cause cancer
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CRB0005708
- Product name
- 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.46
- Updated
- 2021/12/16
- Product number
- MT-08038
- Product name
- 1,6-Dibromo-1,6-dideoxy-D-mannitol
- Purity
- 98%
- Packaging
- 1g
- Price
- $355
- Updated
- 2021/12/16
1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL Chemical Properties,Usage,Production
Originator
Myelobromol,Hormonchemie,W. Germany,1967
Uses
Antineoplastic.
Definition
ChEBI: Mitobronitol is an alcohol and an organobromine compound.
Manufacturing Process
750 g D-mannitol are dissolved in 4,000 ml of a 48% aqueous hydrogenbromide solution, whereupon the solution thus obtained is saturated at 0°Cwith gaseous hydrogen bromide until a HBr content of 69 to 70% is achieved.The reaction mixture is heated for 6 hours at 60°C in an autoclave, is thendecolorized with charcoal, extracted with 1 liter chloroform twice and dilutedwith 7 liters of water. The pH value of the solution is adjusted by means ofsodium bicarbonate to1 to 2. The crystals precipitated after cooling for a dayare filtered and washed with water until free from acid. 250 g crude 1,6-dibromo-1,6-didesoxy-D-mannitol are obtained. MP 176° to 178°C. Analysis:Br % = 52 (calc.: 51.9).
250 g of the crude DBM are dissolved in 2.5 liters of hot methanol and ondecolorizing and filtration 2.5 liters of dichloroethane are added. 220 g ofcrystalline DBM are obtained. MP 178°C. Br % = 51.9.
Therapeutic Function
Cancer chemotherapy
General Description
White powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A halogenated alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Fire Hazard
Flash point data for 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL are not available, but 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL is probably combustible.
1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL manufacturers
- Product
- 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL 488-41-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-05