ChemicalBook > CAS DataBase List > Naled

Naled

Product Name
Naled
CAS No.
300-76-5
Chemical Name
Naled
Synonyms
BRP;NALED;oms75;DIBROM;BROMEX;Alvora;hibrom;naledu;RE-4355;Trumpet
CBNumber
CB9202010
Molecular Formula
C4H7Br2Cl2O4P
Formula Weight
380.78
MOL File
300-76-5.mol
More
Less

Naled Property

Melting point:
212℃ (decomposition)
Boiling point:
110℃ (0.5 Torr)
Density 
1.96 g/cm3
vapor pressure 
2 (quoted, Verschueren, 1983)
refractive index 
1.5108 (28℃)
storage temp. 
0-6°C
solubility 
Freely soluble in ketone, alcohols, aromatic and chlorinated hydrocarbons but sparingly soluble in petroleum solvents and mineral oils (Windholz et al., 1983)
form 
solid
Water Solubility 
2000mg l-1(20 °C)
Specific Gravity
1.96 (20℃)
Merck 
13,6384
BRN 
2049930
Exposure limits
NIOSH REL: TWA 3 mg/m3, IDLH 200 mg/m3; OSHA PEL: TWA 3 mg/m3; ACGIH TLV: TWA 3 mg/m3.
Stability:
Light Sensitive, Moisture Sensitive
EPA Substance Registry System
Naled (300-76-5)
More
Less

Safety

Hazard Codes 
Xn,N,T
Risk Statements 
21/22-36/38-50-25-21
Safety Statements 
36/37-61-26
RIDADR 
3018
WGK Germany 
3
RTECS 
TB9450000
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29199000
Hazardous Substances Data
300-76-5(Hazardous Substances Data)
Toxicity
LD50 in male rats (mg/kg): 250 orally; 800 dermally (Gaines)
IDLA
200 mg/m3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
45429
Product name
Dibrom?
Purity
PESTANAL
Packaging
250mg
Price
$65.4
Updated
2024/03/01
Cayman Chemical
Product number
25783
Product name
Naled
Packaging
100mg
Price
$37
Updated
2024/03/01
TRC
Product number
N245300
Product name
Naled
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
N245300
Product name
Naled
Packaging
250mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
9899AF
Product name
Naled
Packaging
100mg
Price
$139
Updated
2021/12/16
More
Less

Naled Chemical Properties,Usage,Production

Description

Sensitization to Naled seems to be rare.

Description

Naled is an organophosphate insecticide and acaricide that inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It reduces the number of A. sollicitans mosquitos by 97% after one hour when aerially applied at a concentration of 0.1 pounds per acre. Naled (125 ppm AI) induces 100 and 64% mortality of T. telarius adults and immature mites, respectively, in an immediate contact toxicity test but does not induce mortality in mite eggs. It is toxic to rats with an LD50 value of 250 mg/kg. Formulations containing naled have been used in the control of mosquitoes in public areas and of crop-damaging insects in agriculture.

Chemical Properties

Clear Colorless Liquid

Chemical Properties

Naled is a white crystalline solid (when pure) or light straw-colored liquid (above 26.7℃) with a slightly pungent insecticide odor.

Physical properties

Colorless to pale yellow liquid or solid with a pungent odor

Uses

Insecticide used for control of spider mites, sucking and chewing insects in fruits, vegetables and ornamentals. Its use may be restricted.

Uses

A cholinesterase inhibitor. Insecticide; acaricide.

Uses

Insecticide; acaricide.

Uses

Naled is used to control mites, sucking pests and some other insects in a wide variety of crops. It is also used for the control of public and animal health pests including mosquitoes.

Definition

ChEBI: An dialkyl phosphate resulting from the formal condensation of the acidic hydroxy group of dimethyl hydrogen phosphate with the alcoholic hydroxy group of 1,2-dibromo-2,2-dichloroethanol. An organophosphate insecticide, it is no longer approved for use wit in the European Union.

General Description

DIBROM is a white solid that may be dissolved in a liquid organic carrier with a pungent odor. DIBROM is a water emulsifiable liquid. DIBROM is insoluble in water and sinks in water. DIBROM can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. If DIBROM is in liquid form, DIBROM can easily penetrate the soil and contaminate groundwater and nearby streams. DIBROM is used as a pesticide.

Air & Water Reactions

Practically insoluble in water [Farm Chemicals Handbook]. Hydrolyzed slowly in presence of water.

Reactivity Profile

DIBROM is incompatible with the following: Strong oxidizers, acids, sunlight, water [Note: Corrosive to metals. Hydrolyzed in presence of water.] . Unstable in presence of Iron [USCG, 1999]. Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Hazard

Technical compound is a moderately volatile liquid. Bp 110C (0.5 mm Hg). Insoluble in water; slightly soluble in aliphatic solvents; very soluble in aromatic solvents; hydrolyzes in water.

Health Hazard

INHALATION OR INGESTION: Symptoms secondary to cholinesterase inhibition are: headache, giddiness, nervousness, blurred vision, weakness, nausea, cramps, diarrhea, chest discomfort, sweating, miosis, tearing, salivation, and other excessive respiratory tract secretion, vomiting, cyanosis, muscle twitching, and convulsions. EYES: Irritating. SKIN: Irritating-can cause dermatitis.

Fire Hazard

May be combustible. (NOAA, 2007)

Agricultural Uses

Insecticide, Fungicide, Bactericide, Acaricide: Naled is a fast-acting, nonsystemic contact and stomach insecticide used to control aphids, mites, mosquitoes,and flies on crops and in greenhouses, mushroom houses, animal and poultry houses, kennels, food-processing plants, and aquaria and in outdoor mosquito control. Liquid formulations can be applied to greenhouse heating pipes to kill insects by vapor action. It has been used by veterinarians to kill parasitic worms (other than tapeworms) in dogs. Naled may no longer be used in and around the home by residents or professional applicators. Naled is available in dust, emulsion concentrate, liquid, and ULV formulations. Also used in cooling towers, veterinary medicine, pulp and paper mill systems, hospitals, swimming pools, and bathrooms. A U.S. EPA restricted Use Pesticide (RUP). Not approved for use in EU countries. Registered for use in the U.S.

Trade name

AI3-24988®; ARTHODIBROM®; BROMCHLOPHOS®; BROMEX®; DIBROM®; FLYKILLER®; LUCANAL®; HIBROM®; ORTHO® 4355; ORTHODIBROM®; ORTHODIBROMO®; PROKIL® Naled; TRUMPET®

Contact allergens

Naled is an organophosphate cholinesterase inhibitor that is used as an insecticide and acaricide. Sensitization seems to be very rare.

Potential Exposure

A potential danger to those involved in the manufacture, formulation, and application of this insecticide, fungicide, bactericide, acaricide. Also used in cooling towers, veterinary medicine, pulp and paper mill systems; hospitals, swimming pools; and bathrooms.

Carcinogenicity

When dogs were given 0.2, 2.0, or 20 mg/kg/day naled by gavage for 1 year, cholinergic signs (soft stools/diarrhea, salivation, and emesis), increases in mineralization of spinal cord, and mild testicular degeneration in males occurred at 2 and 20 mg/kg/day dose levels . Erythrocyte and brain cholinesterase activities were depressed at the same dose levels. Anemia also occurred at 2 and 20 mg/kg/day, and erythrocyte count, hemoglobin, and hematocrit were reduced. At 20 mg/kg/ day dose level, liver and kidney weights increased but these were not accompanied by histopathological changes. There was no evidence of carcinogenicity.

Environmental Fate

Chemical/Physical. Completely hydrolyzed in water within 2 days (Windholz et al., 1983). In the presence of metals or reducing agents, naled loses bromine, forming dichlorvos (Hartley and Kidd, 1987)
Naled emits toxic fumes of bromines, chlorides and phosphorus oxides when heated to decomposition (Lewis, 1990).

Metabolic pathway

Naled is produced by the photochemical bromination of the dichlorovinyl moiety of dichlorvos. The main route of naled metabolism and transformation in the environment is through debromination to dichlorvos which is probably the active cholinesterase inhibitor in vivo. Naled is also rapidly hydrolysed to bromodichloroacetaldehyde in aqueous environments: consequently much of its detoxification is likely to be via a nonenzymatic hydrolytic route.

Solubility in water

Freely soluble in ketone, alcohols, aromatic and chlorinated hydrocarbons but sparingly soluble in petroleum solvents and mineral oils (Windholz et al., 1983)

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Degradation

Naled is stable when dry but it is rapidly hydrolysed in aqueous media and more rapidly in alkaline and acidic media. It is degraded by sunlight. In the presence of metals and reducing agents, bromine is lost and dichlorvos (2) is formed (PM). In unbuffered aqueous solution naled was rapidly hydrolysed via two routes, one leading to the formation of dimethyl phosphate (3) and bromodichloroacetaldehyde (4) and the second via desmethyhaled (5), which further decomposed to yield bromodichloroacetaldehyde (4) and monomethyl phosphate (6) as shown in Scheme 1. Naled was found to be much less hydrolytically stable than dichlorvos and exhibited a maximum stability at pH 4 (Jentzen and Fischer, 1978).

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Hydrolyzed in presence of water. Degraded by sunlight. Decomposes when heated; on contact with acids, acid fumes; bases, producing fumes of hydrogen chloride, hydrogen bromide, phosphorous oxides. Reacts with acids, strong oxidizers in sunlight. Slowly reacts with water; hydrolysis is; corrosive to metals. Attacks some plastics, rubber and coatings.

Waste Disposal

This pesticide is more stable to hydrolysis than dichlorvos (50% hydrolysis at pH 9 @ 37.5℃ in 301 minutes). It is unstable in alkaline conditions, in presence of iron; and is degraded by sunlight. About 10% hydrolysis per day is obtained in ambient water. Incineration is recommended for large amounts. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Naled Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Naled Suppliers

Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24842
Advantage
65
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TianJin Alta Scientific Co., Ltd.
Tel
022-65378550-8551
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2773
Advantage
58
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9947
Advantage
58
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20)
Fax
0539-6362799(To 20)
Country
China
ProdList
10007
Advantage
58

300-76-5, NaledRelated Search:


  • DIBROM
  • DIBROM (NALED)
  • BROMEX
  • BROMCHLOPHOS
  • BRP
  • 1,2-DIBROMO-2,2-DICHLOROETHYL DIMETHYL-PHOSPHATE
  • RE-4355
  • O,O'-DIMETHYL-1,2-DIBROMO-2,2-DICHLOROETHYL PHOSPHATE
  • NALED
  • Naled 250mg [300-76-5]
  • Naled Solution, 100ppm
  • 1,2-dibromo-2,2-dichloro-ethanodimethylphosphate
  • 1,2-Dibromo-2,2-dichloroethyl dimethyl phosphatic acid
  • bromochlorphos
  • naled (bsi,iso,ansi,esa)
  • DIMETHYL-1,2-DIBROMO-2-DICHLOROETHYL-PHOSPHATE
  • 1,2-DIBROMO-2,2-DICHLOROETHYLDIMETHYLESTERPHOSPHATE
  • O-(1,2-dibromo-2,2-dichloethyl )-0,0-dimethylphosphate
  • naled (ISO) 1,2-dibromo-2,2-dichloroethyl dimethyl phosphate
  • Trumpet
  • Alvora
  • arthodibrom
  • Bromex 50
  • bromex(insecticide)
  • bromex50
  • Dibromfos
  • Dimethyl 1,2-dibromo-2,2-dichloroethyl phosphate
  • dimethyl-1,2-dibromo-2,2-dichloroethylphosphate
  • dimethyl1,2-dibromo-2,2-dichloroethylphosphate
  • ENT 24988
  • ent24988
  • flibolex
  • fosbrom
  • fosforano-1,2-dwubromo-2,2-dwuchloroetylo-o,o-dwumetylowy
  • hibrom
  • Naled dibromo-
  • naled,[liquid]
  • naledu
  • nikabrom
  • o-(1,2-dibrom-2,2-dichlor-aethyl)-o,o-dimethyl-phosphat
  • o-(1,2-dibromo-2,2-dicloro-etil)-o,o-dimetil-fosfato
  • o-(1,2-dibroom-2,2-dichloor-ethyl)-o,o-dimethyl-fosfaat
  • o,2,2-dichloro-1,2-dibromoethylphosphate
  • o,o-dimethyl-o-(1,2-dibrom-2,2-dichlor-aethyl)-phosphat
  • o,o-dimethyl-o-(1,2-dibromo-2,2-dichloroethyl)phosphate
  • o,o-dimethylo-2,2-dichloro-1,2-dibromoethylphosphate
  • o-Dibrom 8E
  • oms75
  • Ortho Dibrom 8E
  • ortho4355
  • orthodibrom
  • Ortho-Dibrom
  • orthodibromo
  • phosphatedeo,o-dimethyleetdeo-(1,2-dibromo-2,2-dichlorethyle)
  • phosphatedeo,o-dimethyleetdeo-(1,2-dibromo-2,2-dichlorethyle)(french)
  • Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester
  • phosphoricacid,1,2-dibromo-2,2-dichloroethyldimethylester
  • (1,2-Dibromo-2,2-dichloroethyl) dimethyl phosphate, Bromchlophos, Naled