(6-BROMO-1H-INDOL-2-YL)METHANOL
- Product Name
- (6-BROMO-1H-INDOL-2-YL)METHANOL
- CAS No.
- 923197-75-5
- Chemical Name
- (6-BROMO-1H-INDOL-2-YL)METHANOL
- Synonyms
- 6-bromo-1H-Indole-2-methanol;1H-Indole-2-methanol, 6-bromo-;(6-BROMO-1H-INDOL-2-YL)METHANOL;6-Bromo-2-(hydroxymethyl)-1H-indole
- CBNumber
- CB3699166
- Molecular Formula
- C9H8BrNO
- Formula Weight
- 226.07
- MOL File
- Mol file
(6-BROMO-1H-INDOL-2-YL)METHANOL Property
- Melting point:
- 111-113°
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Safety
- Safety Statements
- 24/25
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B336468
- Product name
- (6-bromo-1H-indol-2-yl)methanol
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- Z3027
- Product name
- 6-Bromindol-2-methanol
- Packaging
- 100mg
- Price
- $112
- Updated
- 2021/12/16
- Product number
- 4H01-9-21
- Product name
- 6-Bromo-2-(hydroxymethyl)-1H-indole
- Packaging
- 500mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- JK233744
- Product name
- (6-Bromo-1H-indol-2-yl)methanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $335
- Updated
- 2021/12/16
- Product number
- 046983
- Product name
- (6-Bromo-1H-indol-2-yl)methanol
- Purity
- >95%
- Packaging
- 500mg
- Price
- $362
- Updated
- 2021/12/16
(6-BROMO-1H-INDOL-2-YL)METHANOL Chemical Properties,Usage,Production
Chemical Properties
White to light yellow powder or solid
Synthesis
16732-65-3
923197-75-5
General procedure for the synthesis of (6-bromo-1H-indol-2-yl)methanol from 6-bromoindole-2-carboxylic acid: to a solution of 6-bromo-1H-indole-2-carboxylic acid (1.00 g, 4.20 mmol) in tetrahydrofuran (THF, 20.0 mL) was added slowly and dropwise at 0 °C lithium aluminium hydroxide (LiAlH4, 1.0 M solution in THF, 4.20 mL. 4.20 mmol). The reaction mixture was gradually warmed to room temperature with stirring for 4 hours. Upon completion of the reaction, the reaction was quenched by sequential addition of water and 15% aqueous sodium hydroxide (NaOH) solution at 0°C, at which time a precipitate was generated. The reaction mixture was filtered through a diatomaceous earth pad and the filtrate was extracted with ethyl acetate (EtOAc, 3 x 20 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product (6-bromo-1H-indol-2-yl)methanol (696 mg, 73% yield) as a yellow solid. The product was characterized by 1H NMR (500 MHz, CDCl3): δ 7.51 (s, 1H), 7.43 (d, J=8.0 Hz, 1H), 7.20 (dd, J=8.0,1.6 Hz, 1H), 6.38 (s, 1H), 4.83 (d, J=5.6 Hz, 2H).
References
[1] Liebigs Annalen der Chemie, 1986, # 3, p. 438 - 455
[2] Patent: US2012/157469, 2012, A1. Location in patent: Page/Page column 28-29
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 2, p. 364 - 377
(6-BROMO-1H-INDOL-2-YL)METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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