ChemicalBook > CAS DataBase List > 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE

3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE

Product Name
3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
CAS No.
145959-21-3
Chemical Name
3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
Synonyms
3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE;Benzamide, 3-chloro-N-methoxy-N-methyl-
CBNumber
CB3705135
Molecular Formula
C9H10ClNO2
Formula Weight
199.63
MOL File
145959-21-3.mol
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3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE Property

Boiling point:
335.9±25.0 °C(Predicted)
Density 
1.224±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Oil
color 
Colourless
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Safety

HS Code 
2928009090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FC149328
Product name
3-Chloro-N-methoxy-N-methylbenzamide
Packaging
250mg
Price
$52.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC149328
Product name
3-Chloro-N-methoxy-N-methylbenzamide
Packaging
500mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC149328
Product name
3-Chloro-N-methoxy-N-methylbenzamide
Packaging
1g
Price
$156
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC149328
Product name
3-Chloro-N-methoxy-N-methylbenzamide
Packaging
2g
Price
$271
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021721
Product name
3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
Purity
95.00%
Packaging
1G
Price
$289.8
Updated
2021/12/16
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3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE Chemical Properties,Usage,Production

Uses

3-Chloro-N-methoxy-N-methylbenzamide is an intermediate in the synthesis of ketamine related compounds with potential anesthetic properties.

Synthesis

873-63-2

6638-79-5

145959-21-3

General procedure for the synthesis of 3-chloro-N-methoxy-N-methylaniline from 3-chlorobenzyl alcohol and dimethylhydroxylamine hydrochloride: in a pre-oven-dried 15 mL glass vial fitted with a magnetic stir bar, Cu(OAc)2-H2O (12 mg, 6 mol%), N,O-dimethylhydroxylamine hydrochloride (117 mg, 1.2 mmol), 3- chlorobenzyl alcohol (1 mmol), 70% TBHP aqueous solution (0.17 mL, 1.2 mmol), CaCO3 (120 mg, 1.2 mmol), and MeCN (1 mL). Subsequently, the glass vials were rinsed three times with nitrogen and the reaction mixture was stirred at room temperature for 1 hour. Next, the reaction mixture was continued to be stirred at 80 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature. All volatiles were removed under vacuum. The product was extracted with EtOAc (20 mL) and the organic layer was washed with saturated aqueous NaHCO3 solution. Subsequently, the organic layer was dried with Na2SO4 and the solvent was removed under vacuum. Finally, the Weinreb amide product was purified by silica gel column chromatography (100-200 mesh) using a gradient elution of petroleum ether (boiling point 60-80 °C) and EtOAc. All amide products were identified by GC-MS, 1H NMR and 13C NMR spectral analysis.

References

[1] Synthesis (Germany), 2015, vol. 47, # 4, p. 526 - 532

3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE Suppliers

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145959-21-3, 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDERelated Search:

N-METHOXY-N-METHYLBENZAMIDE N-(2-carbamothioylethyl)-5-chloro-2-methoxy-N-methylbenzamide N-(4-aminophenyl)-5-chloro-2-methoxy-N-methylbenzamide 2-bromo-5-chloro-N-methoxy-N-methylbenzamide 5-bromo-2-chloro-N-methoxy-N-methylbenzamide 2-CHLORO-N-METHOXY-N-METHYLBENZAMIDE 4-CHLORO-N-METHOXY-N-METHYLBENZAMIDE 5-CHLORO-N-METHOXY-N-METHYL-2-TETRAZOL-1-YL-BENZAMIDE 3A,11C-DIHYDRO-3H-BENZO[5,6]CHROMENO[4,3-C]ISOXAZOL-1(4H)-YL(3,4-DICHLOROPHENYL)METHANONE Seclazone 3,4-DICHLORO-N-METHOXY-N-METHYLBENZENECARBOXAMIDE 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE Meseclazone

  • 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
  • Benzamide, 3-chloro-N-methoxy-N-methyl-
  • 145959-21-3