3,5-BIS(TRIFLUOROMETHYL)ANISOLE
- Product Name
- 3,5-BIS(TRIFLUOROMETHYL)ANISOLE
- CAS No.
- 349-60-0
- Chemical Name
- 3,5-BIS(TRIFLUOROMETHYL)ANISOLE
- Synonyms
- 3,5-Bis-trifluormethyl-aniso;3,5-BIS(TRIFLUOROMETHYL)ANISOLE;1-Methoxy-3,5-bis(trifluoromethyl)benzene;Benzene, 1-methoxy-3,5-bis(trifluoromethyl)-;1,3-Bis(trifluoromethyl)-5-methoxybenzene, 3,5-Bis(trifluoromethyl)phenyl methyl ether
- CBNumber
- CB3705645
- Molecular Formula
- C9H6F6O
- Formula Weight
- 244.13
- MOL File
- 349-60-0.mol
3,5-BIS(TRIFLUOROMETHYL)ANISOLE Property
- Boiling point:
- 158-160°C
- Density
- 1.352
- refractive index
- 1.4075
- Flash point:
- 158-160°C
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
- BRN
- 2533238
- CAS DataBase Reference
- 349-60-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- HCH0020795
- Product name
- 3,5-BIS(TRIFLUOROMETHYL)ANISOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $149.1
- Updated
- 2021/12/16
- Product number
- Z0532
- Product name
- 3,5-Bis(trifluoromethyl)anisole
- Packaging
- 25g
- Price
- $171
- Updated
- 2021/12/16
- Product number
- 2807-3-X5
- Product name
- 3,5-Bis(trifluoromethyl)anisole
- Packaging
- 25g
- Price
- $397
- Updated
- 2021/12/16
- Product number
- HCH0020795
- Product name
- 3,5-BIS(TRIFLUOROMETHYL)ANISOLE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1170.48
- Updated
- 2021/12/16
- Product number
- 005854
- Product name
- 3,5-Bis(trifluoromethyl)anisole
- Packaging
- 5g
- Price
- $44
- Updated
- 2021/12/16
3,5-BIS(TRIFLUOROMETHYL)ANISOLE Chemical Properties,Usage,Production
Synthesis
328-70-1
124-41-4
349-60-0
The general procedure for the synthesis of 3,5-bis(trifluoromethyl)anisole from 3,5-bis(trifluoromethyl)bromobenzene and sodium methanol was as follows: 25 g of 1-bromo-3,5-bis(trifluoromethyl)benzene (85 mmol) was mixed with 366 mg of copper(I) bromide (CuBr, 3 mol%), 1.57 g of 18-crown-6 (7 mol%), and 92.3 g of sodium methanol in methanol ( 30% concentration, 21% precursor concentration) were mixed and heated to 105 °C. The reaction conversion was >97% as determined by GC (total reaction time 22 h). Subsequently, the reaction mixture was poured into 175 g of water and the pH was adjusted to 5-6 by dropwise addition of hydrochloric acid and then filtered through diatomaceous earth. The aqueous phase was extracted twice with 150 g of dichloromethane. The organic phases were combined and purified by vacuum fractional distillation to afford 16.5 g of 3,5-bis(trifluoromethyl)anisole (68 mmol, 79.4% yield) with a GC purity of >98.5%.
References
[1] Patent: US2008/71084, 2008, A1. Location in patent: Page/Page column 4
3,5-BIS(TRIFLUOROMETHYL)ANISOLE Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-BIS(TRIFLUOROMETHYL)ANISOLE Suppliers
- Tel
- --
- Fax
- --
- info@pschemicals.com
- Country
- The Netherlands
- ProdList
- 2724
- Advantage
- 58
View Lastest Price from 3,5-BIS(TRIFLUOROMETHYL)ANISOLE manufacturers
- Product
- 1-methoxy-3,5-bis(trifluoromethyl)benzene 349-60-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.2%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 3,5-BIS(TRIFLUOROMETHYL)ANISOLE 349-60-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-31