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Sulfacarbamide

Product Name
Sulfacarbamide
CAS No.
547-44-4
Chemical Name
Sulfacarbamide
Synonyms
a435;A 435;Uramid;Urenil;Uractyl;Euvernil;Sulfaurea;Urosulfan;NSC 78438;Sulphaurea
CBNumber
CB3711796
Molecular Formula
C7H9N3O3S
Formula Weight
215.23
MOL File
547-44-4.mol
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Sulfacarbamide Property

Melting point:
146-148° (slight dec)
Density 
1.4565 (rough estimate)
refractive index 
1.6630 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO : ≥ 28 mg/mL (130.09 mM)
form 
Solid
pka
pKa 1.78(H2O t = 25 I = 0.05) (Uncertain);5.42(H2O t = 25 I = 0.05) (Uncertain)
color 
White to off-white
Water Solubility 
2.333g/L(20 ºC)
InChI
InChI=1S/C7H9N3O3S/c8-5-1-3-6(4-2-5)14(12,13)10-7(9)11/h1-4H,8H2,(H3,9,10,11)
InChIKey
WVAKABMNNSMCDK-UHFFFAOYSA-N
SMILES
C1(S(NC(N)=O)(=O)=O)=CC=C(N)C=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S441104
Product name
1-SULFANILYLUREA
Purity
Aldrich
Packaging
1g
Price
$179
Updated
2024/03/01
TRC
Product number
S688947
Product name
Sulfacarbamide-d4
Packaging
1mg
Price
$155
Updated
2021/12/16
TRC
Product number
S688945
Product name
Sulfacarbamide
Packaging
1g
Price
$115
Updated
2021/12/16
AK Scientific
Product number
7956AB
Product name
4-Amino-N-carbamoylbenzenesulfonamide
Packaging
100mg
Price
$126
Updated
2021/12/16
AK Scientific
Product number
7956AB
Product name
4-Amino-N-carbamoylbenzenesulfonamide
Packaging
25mg
Price
$96
Updated
2021/12/16
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Sulfacarbamide Chemical Properties,Usage,Production

Description

Sulfacarbamide is a blood sugar-lowering drug, also acting on the vegetative nervous system.

Chemical Properties

White solid

Uses

Sulfacarbamide-d4 is the labeled analogue of Sulfacarbamide (S688945), an antibiotic which is rapidly absorbed in blister fluid.

Uses

antibacterial

Definition

ChEBI: Sulfacarbamide is a sulfonamide and a member of benzenes.

World Health Organization (WHO)

Sulfacarbamide, a sulfonamide anti-infective agent, was introduced in the 1940's for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The Sulfacarbamide are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfacarbamide still remains available in at least one country for the treatment of urinary infections.

Mechanism of action

Sulfonylureas bind to and inhibit the ATP-sensitive potassium channels (K) on the pancreatic beta cells. As a result, potassium efflux decreases, and the beta-cell membrane depolarizes. Membrane depolarization causes calcium channels to open, leading to calcium influx and increased intracellular calcium, which stimulates insulin secretion from the pancreatic beta cells. Sulfonylureas cause insulin release regardless of blood glucose levels.

Sulfacarbamide Preparation Products And Raw materials

Raw materials

Preparation Products

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547-44-4, SulfacarbamideRelated Search:


  • SULFANILYLUREA
  • 1-(4-Aminobenzenesulfonyl)urea
  • 1-Amino-4-([(aminocarbonyl)amino]sulfonyl)benzene
  • 1-Sulfanilylurea
  • 4-amino-n-(aminocarbonyl)-benzenesulfonamid
  • 4-Amino-N-(aminocarbonyl)benzenesulfonamide
  • 4-Sulfacarbamide
  • A 435
  • a435
  • Benzenesulfonamide, 4-amino-N-(aminocarbonyl)-
  • Benzenesulfonamide,4-amino-N-(aminocarbonyl)-
  • Euvernil
  • N-Sulfanilcarbamide
  • p-Aminobenzenesulfonylurea
  • sulfacarbamide
  • Sulfanilamide, N(sup1)-carbamoyl-
  • Sulfanilcarbamid
  • sulfanilyl-ure
  • Sulfanylharnstoff
  • Sulfanyluree
  • Sulfaurea
  • Sulphaurea
  • Uractyl
  • Uramid
  • Urea, sulfanilyl-
  • Urenil
  • Urosulfan
  • Urosulfane
  • Sulphaminoic acid N-carbamoylamide
  • (4-aminophenyl)sulfonylurea
  • 1-(4-azanylphenyl)sulfonylurea
  • [(4-aMinobenzene)sulfonyl]urea
  • 4-AMino-N-carbaMoylbenzenesulfonaMide
  • [(p-Aminophenyl)sulfonyl]urea
  • A 435 (amide)
  • NSC 78438
  • NSC 78438Q
  • Sulphacarbamide
  • N-[(4-Aminophenyl)sulphonyl]urea (S
  • Inhibitor,inhibit,Sulfacarbamide
  • N-[(4-aminophenyl)sulfonyl]urea (sulfacarbamide)
  • Sulfaguanidine Impurity B
  • Sulfaguanidine EP Impurity B
  • 547-44-4
  • SULFAUREA