Brief introduction Antibacterial activity Cephalosporins Precautions Uses
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Ceftiofur

Brief introduction Antibacterial activity Cephalosporins Precautions Uses
Product Name
Ceftiofur
CAS No.
80370-57-6
Chemical Name
Ceftiofur
Synonyms
CEFTIOFUR HCL;Ceftiofur Free Acid;Ceftiofur crystalline free acid;Ceftiofur, >=98%;EXCENEL;U-67279A;CEFTIOFUR;Cefthiofur;CEFTIFURHCL;Ceftiofuran
CBNumber
CB3713790
Molecular Formula
C19H17N5O7S3
Formula Weight
523.56
MOL File
80370-57-6.mol
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Ceftiofur Property

Melting point:
>212°C (dec.)
Density 
1.81±0.1 g/cm3(Predicted)
storage temp. 
0-6°C
solubility 
DMSO (Slightly), Methanol (Very Slightly, Heated, Sonicated)
pka
2.62±0.50(Predicted)
color 
Off-White to Pale Beige
Stability:
Hygroscopic
InChI
InChI=1S/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-/t12-,16-/m1/s1
InChIKey
ZBHXIWJRIFEVQY-IHMPYVIRSA-N
SMILES
N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\OC)=O)C1=O)SCC(CSC(C1=CC=CO1)=O)=C2C(O)=O
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Safety

Safety Statements 
24/25
WGK Germany 
2
HS Code 
29349990
Hazardous Substances Data
80370-57-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
34001
Product name
Ceftiofur
Purity
VETRANAL?, analytical standard
Packaging
100mg
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
34001
Product name
Ceftiofur
Purity
VETRANAL
Packaging
100mg-r
Price
$92.1
Updated
2021/12/16
Usbiological
Product number
C2591-02
Product name
Ceftiofur
Packaging
500ul
Price
$355
Updated
2021/12/16
Usbiological
Product number
226868
Product name
Ceftiofur
Packaging
500ul
Price
$360
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0000602
Product name
CEFTIOFUR
Purity
95.00%
Packaging
100MG
Price
$716.1
Updated
2021/12/16
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Ceftiofur Chemical Properties,Usage,Production

Brief introduction

Ceftiofur(80370-57-6) is the veterinary-exclusive third-generation cephalosporins successfully developed by United States in the 1980s. It entered into market for the first time in the United States. Owing to their excellent antibacterial activity and pharmacokinetic characteristics, it has been officially approved by the United States, Canada, Japan and some European countries for being use in the treatment of respiratory therapy of beef cattle, dairy cattle, horses, pigs, and sheep. Its appearance is white to light yellow powder. It is insoluble in water, slightly soluble in acetone, and almost insoluble in ethanol.

Antibacterial activity

Ceftiofur has a broad antimicrobial spectrum with strong antibacterial activity with strong antibacterial activity against Gram-positive and Gram-negative bacteria, and some anaerobic bacteria. Yancy RJ et al has studied the 264 pathogen strains from 17 kinds of veterinary clinical bacteria isolated from cattle, pigs, horses, poultry, dogs, and cats. Except S. aureus, the ceftiofur has a stronger antimicrobial activity than ampicillin against almost all strains (including strains production β-lactamase). Salmon S A et al has studied the antibacterial effect of ceftiofur and its major metabolite furan carbonyl ceftiofur on 539 veterinary clinical isolated pathogen strains and has shown that these two drugs has the same or similar antibacterial activity against Gram-negative bacteria.

Cephalosporins

Ceftiofur(80370-57-6) is a kind of animal-specific third-generation cephalosporin antibiotics with broad antibacterial spectrum and strong antibacterial activity. It has strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and anaerobic bacteria with comparable or weaker efficacy as first-generation cephalosporins in treating Gram positive bacteria. It also has strong antibacterial activity against many kinds of Gram-negative bacteria such as E. coli, Salmonella typhi Pasteurella multocida and Pasteurella hemolytica, and Streptococcus, being suitable for treating infection of respiratory, urinary tract and caused by various kinds of susceptible bacteria, especially for the prevention and treatment of the early-stage death of baby chicks caused by E. coli, Salmonella, Pseudomonas aeruginosa and Staphylococcus aureus, E. coli mediated yellow scour of daily old piglet and wound infection caused by cut of the umbilical cord, cutting teeth, and cutting tails as well as the porcine contagious pleuropneumonia and bovine bronchial pneumonia caused by Haemophilus Actinobacillus. It is generally not suitable for the treatment of the cows and goats mastitis. This product has characteristics such as complete intramuscular absorption and a long elimination half-life.
The injection varieties of the third-generation cephalosporins such as cefotaxime, ceftriaxone has a lower efficacy on treating Gram-positive bacteria than the first-generation cephalosporins but has good antibacterial effect against Streptococcus pneumoniae (including penicillin-resistant strains), Streptococcus pyogenes and other kinds of Streptococcus; It has strong antibacterial effect against Escherichia coli, Klebsiella pneumoniae, Proteus bacteria and some other kinds of Gram-negative bacteria; It also has strong effect against Haemophilus influenzae, Neisseria meningitidis, Neisseria gonorrhoeae and Moraxella catarrhalis bacteria while its effect on Serratia, Enterobacter, Acinetobacter and Pseudomonas vary among different bacteria varieties. Drug varieties of anti-Pseudomonas such as ceftazidime, cefoperazone, cefpiramide have a relative poor effect on Gram-positive cocci bacteria while having a comparable antibacterial activity on gram-negative bacilli as other third-generation cephalosporins. It has strong antibacterial activity against Pseudomonas aeruginosa. Most kind of third-generation cephalosporins is highly stable against the broad-spectrum β-lactamase generated by the gram-negative bacillus bacteria.

Precautions

1. Cephalosporins allergic animals should be disabled; animal allergic to penicillin should apply with caution.
2. Application of this drug to the horse under stress conditions can cause acute diarrhea which may be lethal. Once happening, immediately stop and take the appropriate therapeutic measures.
3. Animals of renal insufficiency should pay attention to adjust the dose.
4. Injection-purpose ceftiofur sodium should be dissolved in the water before injection to prepare ceftiofur to a concentration of 50 mg per ml (It can maintain its effect for seven days when stored at 2~8 ℃; it can maintain its effect for 12 hours upon 15~30 ℃ ambient temperature). Use suspension for injection and shake well before use. It is not suitable for been frozen and should be used up within 14 days after the first use.
5. Withdrawal period: injection-purpose ceftiofur sodium: cattle: 3 days; pigs: two days. Ceftiofur hydrochloride suspension: cattle: two days.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Uses

Animal-specific antibiotic medicines used for treating Gram-positive and Gram-negative bacteria and Mycoplasma infection.
Veterinary (original powder)

Chemical Properties

Powder.

Uses

antifungal

Uses

A third generation cephalosporin antibiotic for used in veterinary medicine. It is resistant to antibiotic resistance enzyme beta-lactamase.

Side effects

Adverse effects of Ceftiofur were the first day of intramuscular injection and the mare showed no signs of side effects of the drug. However, 24 hours later, during the second application, the patient experienced incoordination, dizziness and loss of balance. At the same time, dexamethasone was given. Signs returned and the mare returned to normal after the reaction. Treatment with ceftiofur was changed to enrofloxacin and the animal recovered completely.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Ceftiofur Preparation Products And Raw materials

Raw materials

Preparation Products

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Ceftiofur Suppliers

Taizhou Creating Bio-pharm Co.,Ltd.
Tel
+86-0576-88827176 +86-18906581668
Email
post@creatingchemical.com
Country
China
ProdList
171
Advantage
58
Shandong Jihao Biotechnology Co., Ltd.
Tel
0531-69958659 15668363232
Email
8598038@qq.com
Country
China
ProdList
39
Advantage
58
Nanjing Paite Meisheng Technology Co., Ltd
Tel
133-27728092 13327728092
Email
xu_meiqin@petmedtech.com
Country
China
ProdList
30
Advantage
58
Wuhan Xinru Chemical Industry Co., Ltd
Tel
15927387915
Email
2162228368@qq.com
Country
China
ProdList
3410
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
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View Lastest Price from Ceftiofur manufacturers

shandong perfect biotechnology co.ltd
Product
ceftiofur 80370-57-6
Price
US $0.00/KG
Min. Order
5KG
Purity
93% HPLC
Supply Ability
5 TON
Release date
2023-07-06
Nantong Guangyuan Chemicl Co,Ltd
Product
Ceftiofur 80370-57-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-17
Henan Tengmao Chemical Technology Co. LTD
Product
Ceftiofur 80370-57-6
Price
US $110.00-90.00/kilogram
Min. Order
1kilogram
Purity
99%
Supply Ability
10 tons/per week
Release date
2023-12-04

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