Brief introduction Antibacterial activity Cephalosporins Precautions Uses
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Ceftiofur

Brief introduction Antibacterial activity Cephalosporins Precautions Uses
Product Name
Ceftiofur
CAS No.
80370-57-6
Chemical Name
Ceftiofur
Synonyms
EXCENEL;U-67279A;CEFTIOFUR;Cefthiofur;CEFTIFURHCL;CEFTIOFUR HCL;Ceftiofur acid;Ceftiofur, >=98%;Ceftiofur Free Acid;Ceftiofur USP/EP/BP
CBNumber
CB3713790
Molecular Formula
C19H17N5O7S3
Formula Weight
523.56
MOL File
80370-57-6.mol
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Ceftiofur Property

Density 
1.81±0.1 g/cm3(Predicted)
storage temp. 
0-6°C
pka
2.62±0.50(Predicted)
form 
neat
InChIKey
ZBHXIWJRIFEVQY-IHMPYVIRSA-N
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Safety

Safety Statements 
24/25
WGK Germany 
2
HS Code 
29349990
Hazardous Substances Data
80370-57-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
34001
Product name
Ceftiofur
Purity
VETRANAL
Packaging
100mg-r
Price
$92.1
Updated
2020/08/18
Sigma-Aldrich
Product number
34001
Product name
Ceftiofur
Purity
VETRANAL?, analytical standard
Packaging
100 mg
Price
$95
Updated
2021/03/22
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Ceftiofur Chemical Properties,Usage,Production

Brief introduction

Ceftiofur is the veterinary-exclusive third-generation cephalosporins successfully developed by United States in the 1980s. It entered into market for the first time in the United States. Owing to their excellent antibacterial activity and pharmacokinetic characteristics, it has been officially approved by the United States, Canada, Japan and some European countries for being use in the treatment of respiratory therapy of beef cattle, dairy cattle, horses, pigs, and sheep. Its appearance is white to light yellow powder. It is insoluble in water, slightly soluble in acetone, and almost insoluble in ethanol.

Antibacterial activity

Ceftiofur has a broad antimicrobial spectrum with strong antibacterial activity with strong antibacterial activity against Gram-positive and Gram-negative bacteria, and some anaerobic bacteria. Yancy RJ et al has studied the 264 pathogen strains from 17 kinds of veterinary clinical bacteria isolated from cattle, pigs, horses, poultry, dogs, and cats. Except S. aureus, the ceftiofur has a stronger antimicrobial activity than ampicillin against almost all strains (including strains production β-lactamase). Salmon S A et al has studied the antibacterial effect of ceftiofur and its major metabolite furan carbonyl ceftiofur on 539 veterinary clinical isolated pathogen strains and has shown that these two drugs has the same or similar antibacterial activity against Gram-negative bacteria.

Cephalosporins

Ceftiofur is a kind of animal-specific third-generation cephalosporin antibiotics with broad antibacterial spectrum and strong antibacterial activity. It has strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and anaerobic bacteria with comparable or weaker efficacy as first-generation cephalosporins in treating Gram positive bacteria. It also has strong antibacterial activity against many kinds of Gram-negative bacteria such as E. coli, Salmonella typhi Pasteurella multocida and Pasteurella hemolytica, and Streptococcus, being suitable for treating infection of respiratory, urinary tract and caused by various kinds of susceptible bacteria, especially for the prevention and treatment of the early-stage death of baby chicks caused by E. coli, Salmonella, Pseudomonas aeruginosa and Staphylococcus aureus, E. coli mediated yellow scour of daily old piglet and wound infection caused by cut of the umbilical cord, cutting teeth, and cutting tails as well as the porcine contagious pleuropneumonia and bovine bronchial pneumonia caused by Haemophilus Actinobacillus. It is generally not suitable for the treatment of the cows and goats mastitis. This product has characteristics such as complete intramuscular absorption and a long elimination half-life.
The injection varieties of the third-generation cephalosporins such as cefotaxime, ceftriaxone has a lower efficacy on treating Gram-positive bacteria than the first-generation cephalosporins but has good antibacterial effect against Streptococcus pneumoniae (including penicillin-resistant strains), Streptococcus pyogenes and other kinds of Streptococcus; It has strong antibacterial effect against Escherichia coli, Klebsiella pneumoniae, Proteus bacteria and some other kinds of Gram-negative bacteria; It also has strong effect against Haemophilus influenzae, Neisseria meningitidis, Neisseria gonorrhoeae and Moraxella catarrhalis bacteria while its effect on Serratia, Enterobacter, Acinetobacter and Pseudomonas vary among different bacteria varieties. Drug varieties of anti-Pseudomonas such as ceftazidime, cefoperazone, cefpiramide have a relative poor effect on Gram-positive cocci bacteria while having a comparable antibacterial activity on gram-negative bacilli as other third-generation cephalosporins. It has strong antibacterial activity against Pseudomonas aeruginosa. Most kind of third-generation cephalosporins is highly stable against the broad-spectrum β-lactamase generated by the gram-negative bacillus bacteria.

Precautions

1. Cephalosporins allergic animals should be disabled; animal allergic to penicillin should apply with caution.
2. Application of this drug to the horse under stress conditions can cause acute diarrhea which may be lethal. Once happening, immediately stop and take the appropriate therapeutic measures.
3. Animals of renal insufficiency should pay attention to adjust the dose.
4. Injection-purpose ceftiofur sodium should be dissolved in the water before injection to prepare ceftiofur to a concentration of 50 mg per ml (It can maintain its effect for seven days when stored at 2~8 ℃; it can maintain its effect for 12 hours upon 15~30 ℃ ambient temperature). Use suspension for injection and shake well before use. It is not suitable for been frozen and should be used up within 14 days after the first use.
5. Withdrawal period: injection-purpose ceftiofur sodium: cattle: 3 days; pigs: two days. Ceftiofur hydrochloride suspension: cattle: two days.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Uses

Animal-specific antibiotic medicines used for treating Gram-positive and Gram-negative bacteria and Mycoplasma infection.
Veterinary (original powder)

Chemical Properties

Powder.

Uses

antifungal

Uses

A third generation cephalosporin antibiotic for used in veterinary medicine. It is resistant to antibiotic resistance enzyme beta-lactamase.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Ceftiofur Preparation Products And Raw materials

Raw materials

Preparation Products

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Ceftiofur Suppliers

Taizhou Creating Chemical Co., Ltd
Tel
576-88827176
Fax
86- 576 88822496
Email
sonya@creatingchem.com
Country
China
ProdList
129
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Chengdu BoShi Technology Co., Ltd.
Tel
13982188065
Fax
-
Email
2983871989@qq.com
Country
China
ProdList
49
Advantage
55
Fan De(Beijing) Biotechnology Co., Ltd.
Email
liming@bio-fount.com
Country
China
ProdList
9734
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15878
Advantage
69
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
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70
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15424
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XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8965
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Beijing Isomersyn Technology CO;LTD
Tel
010-82954736-
Email
sales@isomersyn.com
Country
China
ProdList
3927
Advantage
57
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
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57
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View Lastest Price from Ceftiofur manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ceftiofur 80370-57-6
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
300 MT
Release date
2020-05-23
career henan chemical co
Product
Ceftiofur 80370-57-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-17

80370-57-6, CeftiofurRelated Search:


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