2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE

Product Name: 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE
CAS No.: 209959-33-1
Chemical Name: 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE
Synonyms: 5-Bromo-N,N-di-Boc-pyrimidin-2-amine;N,N-bis-Boc-2-aMino-5-broMopyriMidine;2-(N,N-BisBOC-Amino)-5-bromopyrimidine;2-Amino-5-bromopyrimidine, 2,2-Bis-BOC protected;2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE;(5-Bromopyrimidin-2-yl)bis(tert-butoxycarbonyl)amine;di-tert-butyl (5-bromopyrimidin-2-yl)imidodicarbonate;2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE, 95+%;2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE ISO 9001：2015 REACH;tert-butyl N-(5-broMopyriMidin-2-yl)-N-[(tert-butoxy)carbonyl]carbaMate
CBNumber: CB3714843
Molecular Formula: C14H20BrN3O4
Formula Weight: 374.23
MOL File: 209959-33-1.mol

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2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE Property

Boiling point:: 415.2±37.0 °C(Predicted)
Density: 1.390
storage temp.: Sealed in dry,Room Temperature
pka: -2.49±0.10(Predicted)
Appearance: white solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B809975
Product name: 2-[Bis(tert-Butoxycarbonyl)amino]-5-bromopyrimidine
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB153559
Product name: 2-[Bis(tert-Butoxycarbonyl)amino]-5-bromopyrimidine
Packaging: 500mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: Z4400
Product name: 2-[Bis(tert-Butoxycarbonyl)amino]-5-bromopyrimidine
Packaging: 1g
Price: $64
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H51-1-2Q
Product name: 2-Amino-5-bromopyrimidine, 2,2-Bis-Boc protected
Packaging: 5G
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB153559
Product name: 2-[Bis(tert-Butoxycarbonyl)amino]-5-bromopyrimidine
Packaging: 1g
Price: $100
Updated: 2021/12/16

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2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

7752-82-1

24424-99-5

209959-33-1

Step A: 2-Amino-5-bromopyrimidine (2.75 g, 15.8 mmol) and di-tert-butyl dicarbonate (7.58 g, 34.8 mmol) were dissolved in pyridine (30 mL) and the reaction was stirred at 70 °C overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was extracted by partitioning with ethyl acetate (EtOAc) and 1N hydrochloric acid aqueous solution. The aqueous layer was extracted once more with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give 2-[bis(tert-butoxycarbonyl)amino]-5-bromopyrimidine (5.5 g, 93% yield) as a white solid. Mass spectrometry (MS) analysis showed m/z 398.2 [M + Na]+.

References

[1] Patent: WO2013/101974, 2013, A1. Location in patent: Paragraph 00816; 00817
[2] Patent: US9617268, 2017, B2. Location in patent: Page/Page column 371
[3] Patent: WO2010/121164, 2010, A2. Location in patent: Page/Page column 93-94
[4] Patent: WO2017/176812, 2017, A1. Location in patent: Paragraph 0276
[5] Patent: EP946508, 2009, B1. Location in patent: Page/Page column 60

2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE Suppliers

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View Lastest Price from 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE manufacturers

Dideu Industries Group Limited

Product: 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE 209959-33-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

209959-33-1, 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINERelated Search:

5-Bromopyrimidine 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE

2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE

2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE, 95+%

2-(N,N-BisBOC-Amino)-5-bromopyrimidine

2-Amino-5-bromopyrimidine, 2,2-Bis-BOC protected

tert-butyl N-(5-broMopyriMidin-2-yl)-N-[(tert-butoxy)carbonyl]carbaMate

(5-Bromopyrimidin-2-yl)bis(tert-butoxycarbonyl)amine

Imidodicarbonic acid 2-(5-bromo-2-pyrimidinyl)-1,3-bis(1,1-dimethylethyl) ester

N,N-bis-Boc-2-aMino-5-broMopyriMidine

N-(5-bromo-2-pyrimidinyl)-N-[(2-methylpropan-2-yl)oxy-oxomethyl]carbamic acid tert-butyl ester

di-tert-butyl (5-bromopyrimidin-2-yl)imidodicarbonate

2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE ISO 9001：2015 REACH

5-Bromo-N,N-di-Boc-pyrimidin-2-amine

209959-33-1

C14H20BrN3O4

pyrimidine

Heterocycle-Pyrimidine series

API intermediates