4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER
- Product Name
- 4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER
- CAS No.
- 28269-03-6
- Chemical Name
- 4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER
- Synonyms
- -DimethyL;(1R,2R)-reL;opentane-1,2-dicarboxyL;trans-Dimethyl 4-oxocyclopentane-1,2-dicarboxylate;dimethyl trans-4-oxocyclopentane-1,2-dicarboxylate;Dimethyl (1R,2R)-4-oxocyclopentane-1,2-dicarboxylate;(1R,2R)-rel-Dimethyl 4-oxocyclopentane-1,2-dicarboxylate;dimethyl Rel-(1R,2R)-4-oxocyclopentane-1,2-dicarboxylate;4-Oxo-cyclopentane-trans-1,2-dicarboxylic acid methyl ester;4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER
- CBNumber
- CB3719404
- Molecular Formula
- C9H12O5
- Formula Weight
- 200.19
- MOL File
- 28269-03-6.mol
4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER Property
- Boiling point:
- 299.0±40.0 °C(Predicted)
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- off-white solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2229-1-30
- Product name
- 4-Oxocyclopentane-trans-1,2-dicarboxylic acid, dimethyl ester
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 112801
- Product name
- 4-Oxo-cyclopentane-trans-1,2-dicarboxylic acid dimethyl ester
- Packaging
- 1g
- Price
- $167
- Updated
- 2021/12/16
- Product number
- 2229-1-30
- Product name
- 4-Oxocyclopentane-trans-1,2-dicarboxylic acid, dimethyl ester
- Packaging
- 5G
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 2804AL
- Product name
- 4-oxo-Cyclopentane-trans-1,2-dicarboxylicaciddimethylester
- Packaging
- 10g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- 112801
- Product name
- 4-Oxo-cyclopentane-trans-1,2-dicarboxylic acid dimethyl ester
- Packaging
- 5g
- Price
- $466
- Updated
- 2021/12/16
4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER Chemical Properties,Usage,Production
Synthesis
67-56-1
1703-61-3
6453-07-2
1. 4.5 kg (26.1 mol) of 4-cyclopentanone-1,2-dicarboxylic acid (Compound IV) was added to a solvent mixture of 20 L of methanol and 30 L of toluene. 2. 0.831 kg (13.7 mol) of concentrated sulfuric acid was added slowly dropwise, with the rate of dropwise acceleration controlled to maintain the reaction temperature below 30 °C. 3. the reaction mixture was heated to 70 °C with continuous stirring until dimethyl 4-oxocyclopentane-1,2-dicarboxylate (Compound JY) was completely converted (about 1-3 hours). 4. Upon completion of the reaction, the reaction solution was concentrated to half of the original volume (approximately 24 L of solvent was distilled). 5. The reaction mixture was cooled to 30 °C, 25 L of water and 6 L of methyl tert-butyl ether (MeTHF) were added sequentially and stirred for 1 h. Phase separation was carried out. 6. Discard the aqueous layer, the organic layer was washed sequentially with 10L of water, 10L of saturated sodium bicarbonate solution and 5L of brine. 7. The washed organic layer was concentrated to a final volume of about 9L. 8. The yield of dimethyl 4-oxocyclopentane-1,2-dicarboxylate in the resulting solution was determined by quantitative analysis to be 4.5 kg (86% yield), and the solution was used directly in the next step of the reaction.
References
[1] Patent: WO2016/157058, 2016, A1. Location in patent: Page/Page column 22; 32
[2] Synlett, 1997, vol. 1997, # 2, p. 193 - 194
4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER manufacturers
- Product
- 4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER 28269-03-6
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-08