4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER

Product Name: 4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER
CAS No.: 28269-03-6
Chemical Name: 4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER
Synonyms: -DimethyL;(1R,2R)-reL;opentane-1,2-dicarboxyL;trans-Dimethyl 4-oxocyclopentane-1,2-dicarboxylate;dimethyl trans-4-oxocyclopentane-1,2-dicarboxylate;Dimethyl (1R,2R)-4-oxocyclopentane-1,2-dicarboxylate;(1R,2R)-rel-Dimethyl 4-oxocyclopentane-1,2-dicarboxylate;dimethyl Rel-(1R,2R)-4-oxocyclopentane-1,2-dicarboxylate;4-Oxo-cyclopentane-trans-1,2-dicarboxylic acid methyl ester;4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER
CBNumber: CB3719404
Molecular Formula: C9H12O5
Formula Weight: 200.19
MOL File: 28269-03-6.mol

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4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER Property

Boiling point:: 299.0±40.0 °C(Predicted)
Density: 1.247±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: off-white solid

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
HS Code: 2917399590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 2229-1-30
Product name: 4-Oxocyclopentane-trans-1,2-dicarboxylic acid, dimethyl ester
Packaging: 1g
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 112801
Product name: 4-Oxo-cyclopentane-trans-1,2-dicarboxylic acid dimethyl ester
Packaging: 1g
Price: $167
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2229-1-30
Product name: 4-Oxocyclopentane-trans-1,2-dicarboxylic acid, dimethyl ester
Packaging: 5G
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: 2804AL
Product name: 4-oxo-Cyclopentane-trans-1,2-dicarboxylicaciddimethylester
Packaging: 10g
Price: $277
Updated: 2021/12/16

Matrix Scientific

Product number: 112801
Product name: 4-Oxo-cyclopentane-trans-1,2-dicarboxylic acid dimethyl ester
Packaging: 5g
Price: $466
Updated: 2021/12/16

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4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER Chemical Properties,Usage,Production

Synthesis

67-56-1

1703-61-3

6453-07-2

1. 4.5 kg (26.1 mol) of 4-cyclopentanone-1,2-dicarboxylic acid (Compound IV) was added to a solvent mixture of 20 L of methanol and 30 L of toluene. 2. 0.831 kg (13.7 mol) of concentrated sulfuric acid was added slowly dropwise, with the rate of dropwise acceleration controlled to maintain the reaction temperature below 30 °C. 3. the reaction mixture was heated to 70 °C with continuous stirring until dimethyl 4-oxocyclopentane-1,2-dicarboxylate (Compound JY) was completely converted (about 1-3 hours). 4. Upon completion of the reaction, the reaction solution was concentrated to half of the original volume (approximately 24 L of solvent was distilled). 5. The reaction mixture was cooled to 30 °C, 25 L of water and 6 L of methyl tert-butyl ether (MeTHF) were added sequentially and stirred for 1 h. Phase separation was carried out. 6. Discard the aqueous layer, the organic layer was washed sequentially with 10L of water, 10L of saturated sodium bicarbonate solution and 5L of brine. 7. The washed organic layer was concentrated to a final volume of about 9L. 8. The yield of dimethyl 4-oxocyclopentane-1,2-dicarboxylate in the resulting solution was determined by quantitative analysis to be 4.5 kg (86% yield), and the solution was used directly in the next step of the reaction.

References

[1] Patent: WO2016/157058, 2016, A1. Location in patent: Page/Page column 22; 32
[2] Synlett, 1997, vol. 1997, # 2, p. 193 - 194

4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER manufacturers

Career Henan Chemical Co

Product: 4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER 28269-03-6
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-08

28269-03-6, 4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTERRelated Search:

trans-4-(trans-4-Butylcyclohexyl)cyclohexylanone trans-4′-Ethyl-1,1′-bicyclohexyl-4-on 4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER trans-DL-1,2-Cyclopentanedicarboxylic acid SALOR-INT L165123-1EA DIMETHYL 4-OXO-1,2-CYCLOPENTANEDICARBOXYLATE 4-KETOPIMELIC ACID 4-oxocyclopentane-1,2-dicarboxylic acid methyl 3-oxocyclopentane-1-carboxylate

4-Oxo-cyclopentane-trans-1,2-dicarboxylic acid methyl ester

trans-Dimethyl 4-oxocyclopentane-1,2-dicarboxylate

(1R,2R)-rel-Dimethyl 4-oxocyclopentane-1,2-dicarboxylate

4-Oxo-cyclopentane-trans-1,2-dicarboxylic acid dimethyl ester - X11214

TRANS-4-OXO-CYCLOPENTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER

4-OXO-CYCLOPENTANE-TRANS-1,2-DICARBOXYLIC ACID DIMETHYL ESTER

Dimethyl (1R,2R)-4-oxocyclopentane-1,2-dicarboxylate

(1R,2R)-reL

opentane-1,2-dicarboxyL

1,2-Cyclopentanedicarboxylic acid, 4-oxo-, 1,2-dimethyl ester, (1R,2R)-rel-

-DimethyL

dimethyl trans-4-oxocyclopentane-1,2-dicarboxylate

dimethyl Rel-(1R,2R)-4-oxocyclopentane-1,2-dicarboxylate

28269-03-6