6-THIOGUANOSINE Property

Melting point:

230-231°C

Boiling point:

756.9±70.0 °C(Predicted)

Density 

2.18

refractive index 

1.6460 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

form 

Solid

pka

13.21±0.70(Predicted)

color 

Off-white to light yellow

CAS DataBase Reference

85-31-4(CAS DataBase Reference)

Safety

Safety Statements 

24/25

RTECS 

UP0200000

HS Code 

29349990

Toxicity

LD50 intraperitoneal in mouse: 156mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

6-THIOGUANOSINE Chemical Properties,Usage,Production

Chemical Properties

Tan Powder

Uses

antineoplastic

Definition

ChEBI: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-3H-purine-6-thione is a purine nucleoside.

Purification Methods

Thioguanosine is crystallised (as hemihydrate) from hot H2O (charcoal) and cooled slowly to give tapered prisms. It also crystallises by dissolving in dilute NH3 and acidifying with acetic acid, and then recrystallising from H2O. UV: (pH 4-6) max at 257nm ( 8,820) and 342nm ( 24,800), and (pH 10.4-12.0) max at 252nm ( 14,700) and 319.5nm ( 21,000). [Fox et al. J Am Chem Soc 80 1667 1958, Beilstein 26 III/IV 3927.]