CALPAIN INHIBITOR III
- Product Name
- CALPAIN INHIBITOR III
- CAS No.
- 88191-84-8
- Chemical Name
- CALPAIN INHIBITOR III
- Synonyms
- CS-1705;Calp III;MDL 28170;Z-Val-Phe-H;Z-VAL-PHE-CHO;4R)-Tofacitinib;Z-L-Val-L-Phe-OH;Z-VAL-PHE-ALDEHYDE;Cbz-L-Val-L-Phe-OH;CALPAIN INHIBITOR III
- CBNumber
- CB3723465
- Molecular Formula
- C22H26N2O4
- Formula Weight
- 382.45
- MOL File
- 88191-84-8.mol
CALPAIN INHIBITOR III Property
- Boiling point:
- 595.6±50.0 °C(Predicted)
- Density
- 1.153±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 26 mg/mL
- form
- White lyophilized solid
- pka
- 11.05±0.46(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 2924297099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- M6690
- Product name
- MDL 28170
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $260
- Updated
- 2024/03/01
- Product number
- 208722
- Product name
- Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem
- Packaging
- 25MG
- Price
- $216
- Updated
- 2024/03/01
- Product number
- J62919
- Product name
- Calpain Inhibitor III, 95+%
- Packaging
- 25mg
- Price
- $139
- Updated
- 2023/06/20
- Product number
- 14283
- Product name
- Calpain Inhibitor III
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 14283
- Product name
- Calpain Inhibitor III
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
CALPAIN INHIBITOR III Chemical Properties,Usage,Production
Description
MDL-28170 (88191-84-8) is a potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1?It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2?Displays neuroprotective effects in neurotrauma rodent models.3?Calpain I Ki?= 8 nM; Cathepsin B Ki?= 24 nM in isolated enzyme assays. IC50?= 0.3 μM in intact cell assay.4
Uses
MDL 28170 acts as a caplain inhibitor reducing hypoxia in ischemic-retinopathy, and various other neuroprotective effects.
Uses
Inhibits calpain proteolysis
Definition
ChEBI: A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpai I and II, and is also a gamma-secretase inhibitor.
General Description
A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
Biological Activity
Potent, selective inhibitor of calpain and cathepsin B (K i values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo .
Biochem/physiol Actions
Cell permeable: yes
References
1) Chard?et al.?(1995),?Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: involvement of calcium-activated proteases; Neuroscience,?65?1099 2) Li?et al.?(1998),?Postischemic treatment with calpain inhibitor MDL28170 ameliorates brain damage in a gerbil model of global ischemia; Neurosci. Lett.,?247?17 3) Thompson?et al. (2010),?A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model; J. Neurotrauma,?27?2233 4) Chatterjee?et al.?(1998),?D-amino acid containing, high-affinity inhibitors of recombinant human calpain I; J. Med. Chem.,?41?2663
CALPAIN INHIBITOR III Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CALPAIN INHIBITOR III manufacturers
- Product
- CALPAIN INHIBITOR III 88191-84-8
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18