ChemicalBook > CAS DataBase List > 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID

1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID

Product Name
1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
CAS No.
5733-86-8
Chemical Name
1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
Synonyms
AKOS BB-9373;AURORA 17719;BUTTPARK 17\07-15;IFLAB-BB F1799-0573;TIMTEC-BB SBB011410;OTAVA-BB BB7018611176;1-Benzyl-5-oxopyrrolidine...;1-Benzyl-4-carboxy-2-pyrrolidone;1-Benzyl-4-carboxy-2-pyrrolidinone;1-benzyl-5-oxo-3-pyrrolidinecarboxylicaci
CBNumber
CB3726244
Molecular Formula
C12H13NO3
Formula Weight
219.24
MOL File
5733-86-8.mol
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1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Property

Melting point:
142.0 to 146.0 °C
Boiling point:
471.3±45.0 °C(Predicted)
Density 
1.314±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
4.51±0.20(Predicted)
color 
White to Almost white
CAS DataBase Reference
5733-86-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
RTECS 
UY0686500
HazardClass 
IRRITANT
HS Code 
2933790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H320Causes eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4264
Product name
1-Benzyl-5-oxopyrrolidine-3-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$159
Updated
2022/04/27
TRC
Product number
B521445
Product name
1-Benzyl-5-oxopyrrolidine-3-carboxylic Acid
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB112131
Product name
1-Benzyl-5-oxopyrrolidine-3-carboxylic acid
Packaging
250mg
Price
$85
Updated
2021/12/16
Apolloscientific
Product number
OR6330
Product name
1-Benzyl-5-oxopyrrolidine-3-carboxylic Acid
Purity
97%
Packaging
5g
Price
$109
Updated
2021/12/16
SynQuest Laboratories
Product number
4H29-1-53
Product name
1-Benzyl-5-oxopyrrolidine-3-carboxylic acid
Purity
97%
Packaging
5G
Price
$120
Updated
2021/12/16
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1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

51535-00-3

5733-86-8

Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate (2.00 g, 8.57 mmol) was used as a raw material and dissolved in a mixed solvent of methanol (10 mL) and tetrahydrofuran (10 mL). Subsequently, 2 N aqueous lithium hydroxide (8.6 mL) was added to this solution. The reaction mixture was heated to reflux for 20 minutes. Upon completion of the reaction, the reaction solution was cooled in an ice bath, adjusted to acidity with aqueous potassium bisulfate, and then extracted with ethyl acetate. The organic layers were combined, concentrated and purified by repurification (ethyl acetate/hexane) and dried to give 1-benzyl-5-oxo-3-pyrrolidinecarboxylic acid (1.83 g, 97% yield).1H-NMR (DMSO-d6) δ: 2.56 (2H, m), 3.80 (1H, m), 3.15 (2H, m), 3.25 (2H, m), 4.36 (2H , q, J = 8.6 Hz), 7.27 (5H, m), 12.61 (1H, s).

References

[1] Patent: EP1403255, 2004, A1. Location in patent: Page 78
[2] Journal of Medicinal Chemistry, 1997, vol. 40, # 15, p. 2374 - 2385
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 377 - 379
[4] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[5] Patent: WO2006/123725, 2006, A1. Location in patent: Page/Page column 64-65

1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Suppliers

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View Lastest Price from 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
4-(2-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE 5733-86-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2020-03-05

5733-86-8, 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACIDRelated Search:

Pyrroloquinoline quinone ETHYL1-BENZYL-5-OXOPYRROLIDINE-3-CARBOXYLATE 1-(4-PROPYLPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLICACID 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER ,1-Benzyl-5-oxo-3-pyrrolidinecarboxylic acid methyl ester (S)-1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER 1-(4-ISOPROPYLPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLIC ACID 1-(4-METHYL-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID (2s,4r)-1-boc-4-benzyl-5-oxo-2-pyrrolidinecarboxylic acid,(2S,4R)-1-Boc-4-benzyl-5-oxo-2-pyrrolidinecarboxylic acid, (4R)-Boc-4-benzyl-L-pyroglutamic acid (R)-1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 1-(2-METHOXY-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 1-BENZYL-4-OXO-3-PYRROLIDINECARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE (R)-1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER 1-(4-FLUORO-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 1-(4-METHOXY-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 1-(4-ETHOXY-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID AMIDE (S)-1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid

  • 5-Oxo-1-benzyl-3-pyrrolidinecarboxylic acid
  • 1-Benzyl-5-oxopyrrolidine-3-carboxylicacid97%
  • AURORA 17719
  • BUTTPARK 17\07-15
  • IFLAB-BB F1799-0573
  • 1-BENZYL-5-OXO-3-PYRROLIDINECARBOXYLIC ACID
  • 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
  • AKOS BB-9373
  • OTAVA-BB BB7018611176
  • TIMTEC-BB SBB011410
  • 1-benzyl-5-oxo-3-pyrrolidinecarboxylicaci
  • 5-oxo-1-(phenylmethyl)-3-pyrrolidinecarboxylicaci
  • 5-oxo-1-(phenylmethyl)-3-pyrrolidinecarboxylicacid
  • 1-Benzyl-5-oxopyrrolidine-3-carboxylic acid 97%
  • 1-Benzyl-4-carboxy-2-pyrrolidone
  • 1-Benzyl-5-oxopyrrolidine...
  • 1-benzyl-5-oxopyrrolidine-3-carboxylic acid(SALTDATA: FREE)
  • 1-Benzyl-5-oxopyrrolidine-3-carboxylicAcid&gt
  • 3-Pyrrolidinecarboxylic acid, 5-oxo-1-(phenylmethyl)-
  • 1-Benzyl-4-carboxy-2-pyrrolidinone
  • 2-(5-FLUORO-2-HYDROXYPHENYL)-2-(1-OXOISOINDOLIN-5-YL)ACETICACID
  • 5-Oxo-1-(benzyl)-pyrrolidine-3-carboxylic acid
  • 1-Benzyl-2-oxopyrrolidine-4-carboxylic acid
  • 1-Benzyl-5-oxo-pyrroline-3-carboxylic acid
  • 5733-86-8
  • 5733-86-6
  • CARBOXYLIC ACID
  • pharmacetical
  • Carboxylic Acids
  • Pyrrolidines
  • Carboxylic Acids