Rebaudioside A

Product Name: Rebaudioside A
CAS No.: 58543-16-1
Chemical Name: Rebaudioside A
Synonyms: REBAUDIOSIDE;Steviol Glycoside;Reb A;4G-S;Rebiana;Reb-A 97;Pure Via;Glycoside X;Lebaldide A;Glycoside A3
CBNumber: CB3736050
Molecular Formula: C44H70O23
Formula Weight: 967.01
MOL File: 58543-16-1.mol

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Rebaudioside A Property

Melting point:: 235°C(lit.)
Boiling point:: 1102.8±65.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
vapor pressure: 0-1198Pa at 20-50℃
refractive index: 1.662
FEMA: 4601 | REBAUDIOSIDE A
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
form: Solid
pka: 12.51±0.70(Predicted)
color: White to Off-White
Odor: Mild odor
biological source: plant
optical activity: [α]/D -33.0±3.0°, c = 1% in H2O
Water Solubility: water: soluble
BRN: 6470556
Stability:: Hygroscopic
LogP: -1-2.61 at 20-25℃ and pH7

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: NZ8174800
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL80067
Product name: Rebaudioside A
Purity: phyproof? Reference Substance
Packaging: 20MG
Price: $294
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1600121
Product name: Rebaudioside A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $627
Updated: 2025/07/31

Sigma-Aldrich

Product number: 01432
Product name: Rebaudioside A
Purity: ≥96% (HPLC)
Packaging: 10g
Price: $145
Updated: 2025/07/31

TCI Chemical

Product number: R0095
Product name: Rebaudioside A
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $77
Updated: 2025/07/31

TCI Chemical

Product number: R0095
Product name: Rebaudioside A
Purity: >98.0%(HPLC)
Packaging: 25g
Price: $269
Updated: 2025/07/31

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Rebaudioside A Chemical Properties,Usage,Production

Description

Rebaudioside A is a natural non-caloric sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. It increases glucagon-like peptide 1 (GLP-1) secretion in a 2-dimensional mouse intestine model. In a two bottle preference test, mice drink more water containing rebaudioside A than unsweetened water, though saccharin-sweetened water is still preferred. Rebaudioside A is metabolized by gut microbiota to steviol , a compound whose safety is widely studied. Consumption of rebaudioside A formulations by pre-diabetic patients did not increase fasting or 2 hour plasma glucose levels or insulin levels.

Chemical Properties

White powder

Uses

Rebaudioside A is a glycoside from the stevia plant. Rebaudioside A is used as a sweetener with sweetness about 300 times that of sugar with negligible effect on blood glucose. As a result, Rebaudiosi de A is known for its application in treatment of many diseases like diabetes, high blood pressure and weight loss in some places. It is used as a food additive and in dietary supplements.

Uses

natural sweetener to diabetics and others on carbohydrate-controlled diets

Uses

Rebaudioside A is a natural, highly processed calorie free sweetener obtained from the leaves of the plant stevia rebaudiana bertoni. it is a steviol glycoside in which the steviol’s carboxyl and hydroxyl hydrogen atom is replaced with glucose, it has three linked glucose molecules at the hydroxyl site. rebaudiana (reb a) is 300–400 times sweeter than sugar and the least bitter of the glycosides. it is ph and heat stable with good solubility in water. uses include beverages, table top sweetener, general foods. it is also termed reb a, stevia extract, stevia.

Definition

Rebaudioside A is a rebaudioside that is rubusoside in which the hydroxy groups at positions 3 and 4 of the beta-D-glucopyranosyloxy group at the 13alpha position have both been converted to the corresponding beta-D-glucopyranoside. It has a role as a sweetening agent. It is a beta-D-glucoside, a tetracyclic diterpenoid and a rebaudioside. It derives from a rubusoside and a beta-D-Glcp-(1->2)-[beta-D-Glcp-(1->3)]-beta-D-Glcp.

benefits

Zero calories
No carbohydrate
Does not raise blood glucose or insulin levels (Zero Index Glycemic), safe for people with diabetes
Keto, Vegan, and Gluten-Free

Biological Activity

Rebaudioside A is a natural non-caloric sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. It increases glucagon-like peptide 1 (GLP-1) secretion in a 2-dimensional mouse intestine model. In a two bottle preference test, mice drink more water containing rebaudioside A than unsweetened water, though saccharin-sweetened water is still preferred. Rebaudioside A is metabolized by gut microbiota to steviol, a compound whose safety is widely studied. Consumption of rebaudioside A formulations by pre-diabetic patients did not increase fasting or 2 hour plasma glucose levels or insulin levels.

Safety

High-purity (95% minimum) of individual or combined steviol glycosides can be considered as GRAS (Generally Recognized as Safe) by the FDA. For example, FDA had no questions regarding Guilin Layn's conclusion that its reb A (≥97% by weight (w/w)) is GRAS as a table top sweetener and as a general purpose sweetener in foods, excluding meat and poultry products and infant formulas.
Its safety has also been approved by the EFSA, JECFA, FSANZ and other authorities.

Synthesis

57817-89-7

57-50-1

58543-16-1

A new structure based on (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl((4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R )-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methylcyclohepta[a]naphthalene-4-carboxylic acid ester and sucrose were used as raw materials, and the general procedure for the synthesis of rebaudioside A was as follows: firstly, the expression in E. coli of pEUGT- SUS vector in E. coli, followed by collecting the cells and washing them twice with potassium phosphate buffer (100 mM, pH 7.2). Next, the cells were broken by sonication in an ice-water bath and centrifuged at 4°C to remove cellular debris to obtain a lysate supernatant containing soluble proteins. This supernatant is the crude extract. The total protein concentration of the crude extract was determined by the Bradford method using bovine serum albumin (BSA) as a standard. Finally, rebaudioside A was synthesized by reacting the substrate acaricide with an equal volume of the crude extract in potassium phosphate buffer (100 mM, pH 7.2) containing different concentrations of UDP-glucose or UDP, sucrose, and 3 mM MgCl2 at 30 °C.

References

[1] Bioscience, Biotechnology and Biochemistry, 2016, vol. 80, # 1, p. 67 - 73

Rebaudioside A Preparation Products And Raw materials

Raw materials

Preparation Products

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Rebaudioside A Suppliers

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View Lastest Price from Rebaudioside A manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: REBAUDIOSIDE A 58543-16-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Henan Fengda Chemical Co., Ltd

Product: Rebaudioside A 58543-16-1
Price: US $10.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-28

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: stock Rebaudioside A 58543-16-1 58543-16-1
Price: US $60.00/mg
Min. Order: 20mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-11

58543-16-1, Rebaudioside ARelated Search:

CYCLOPENTADECANE METHYL CYCLOHEXANEACETATE ETHYL CYCLOHEXYLACETATE D-(-)-GULOSE Steviol Rebaudioside A Isophytol DELTA 12 CIS TRIDECENOIC ACID METHYL ESTER 4-tert-Butylcyclohexanol 1-VINYLCYCLOHEXANOL 97 CIS-4-TERT-BUTYLCYCLOHEXANOL CYCLOPENTADECANOL BUTYL UNDECYLENATE REBAUDIOSIDE A(P),REBAUDIOSIDE A(RG) REBAUDIOSIDE B(P) Stevioside propyl cyclohexaneacetate hexyl pivalate

(4α)-13-[(2-O-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]kaur-6-en-8-oic acid β-D-glucopyranosyl ester

Rebaudioside A (300 mg)

REBAUDIOSIDE A(rebiana)(RG)

(4α)-13-[(O-β-D-Glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl)oxy]kaur-16-en-18-oic Acid β-D-Glucopyranosyl Ester

4G-S

Glycoside A3, froM Stevia rebaudiana

Glycoside X

Pure Via

Reb-A 97

stock Rebaudioside A 58543-16-1

Rebaudioside A 50% (RA50)

Rebiana

Sooolite!-Pure

Sweetener 4G-S

Rebaudioside A, froM Steviarebaudiana

Rebaudioside A (500 mg)

(4α)-13-[(2-O-β-D-glucopyranosyl-3-O-β-D&shy

glucopyranosyl-β-D-glucopyranosyl)-oxy]kaur-6-en-8-oic acid β-D&shy

STEVIOSIDE A3

MONOGLYCOSYLSTEVIOSIDE

REBAUDIOSIDE

REBAUDIOSIDE, 60%

RebaudiosideA(enzymaticallymodified)

REBAUDIOSIDE A STANDARD

(4R)-13-[(2-O-β-D-Glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]kaur-16-en-18-oic acid β-D-glucopyranosyl ester

Rebaudioside A, 97%, from Steviarebaudiana

A Rebaudioside A &gt

Glycoside A3

Reb A

Kaur-16-en-18-oic acid, 13-[(O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl)oxy]-, β-D-glucopyranosyl ester, (4α)-

Steviol Glycoside

REBAUDIOSIDE A USP/EP/BP

Kaur-16-en-18-oic acid,13-[(O-b-D-glucopyranosyl-(1?2)-O-[b-D-glucopyranosyl-(1?3)]-b-D-glucopyranosyl)oxy]-, b-D-glucopyranosyl ester, (4a)-

Rebaudioside A

Lebaldide A

(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylate

Lepidoside A

Stevia diglycoside/Reb A

Rebaudioside A [-1.0mg/ml](P)

Rebaudioside A(Rebiana)(SH)

Rebaudioside A-RM

Rebaudioside A, 10 mM in DMSO

Rebaudioside A 98

Stevioside A

58543-16-1

C44H70O23

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