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2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID

Product Name
2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID
CAS No.
10058-38-5
Chemical Name
2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID
Synonyms
2-Phenyl-5-carboxythiazole;2-phenyl-5-thiazolecarboxylic acid;2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID;5-Thiazolecarboxylic acid, 2-phenyl-;2-phenyl-1,3-thiazole-5-carboxylic acid;2-PHENYL-1,3-THIAZOLE-5-CARBOXYLICACID2-PHENYL-1,3-OXAZOLE-5-CARBOXYLICACID
CBNumber
CB3741836
Molecular Formula
C10H7NO2S
Formula Weight
205.23
MOL File
Mol file
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2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID Property

Melting point:
186 °C
Boiling point:
420.5±37.0 °C(Predicted)
Density 
1.368±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
2.78±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2934208090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P399690
Product name
2-Phenylthiazole-5-carboxylicAcid
Packaging
25mg
Price
$45
Updated
2021/12/16
TRC
Product number
P399690
Product name
2-Phenylthiazole-5-carboxylicAcid
Packaging
250mg
Price
$285
Updated
2021/12/16
Matrix Scientific
Product number
059223
Product name
2-Phenyl-thiazole-5-carboxylic acid
Purity
95+%
Packaging
500mg
Price
$388
Updated
2021/12/16
Matrix Scientific
Product number
059223
Product name
2-Phenyl-thiazole-5-carboxylic acid
Purity
95+%
Packaging
1g
Price
$598
Updated
2021/12/16
Apolloscientific
Product number
OR300695
Product name
2-Phenylthiazole-5-carboxylic acid
Packaging
250mg
Price
$98
Updated
2021/12/16
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2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

172678-67-0

10058-38-5

General procedure for the synthesis of 2-phenylthiazole-5-carboxylic acid from ethyl 2-phenylthiazole-5-carboxylate: to a solution of ethyl 2-phenylthiazole-5-carboxylate (3.2 g, 13.8 mmol) in methanol (50 mL) was added a sodium hydroxide solution (130 mL, 4 M). The reaction mixture was stirred at room temperature for 2 hours and subsequently concentrated under reduced pressure to remove methanol. The aqueous phase was acidified to pH=3 with aqueous hydrochloric acid (1 M) and subsequently extracted with ethyl acetate. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography, eluting to give 2-phenylthiazole-5-carboxylic acid (2.3 g, 81.8% yield).MS m/z [ESI]: 206.0 [M+H]+.

References

[1] Patent: US2018/271846, 2018, A1. Location in patent: Paragraph 0121; 0126; 0127
[2] Patent: WO2018/160878, 2018, A1. Location in patent: Page/Page column 288
[3] Journal of the American Chemical Society, 1943, vol. 65, p. 2167
[4] Helvetica Chimica Acta, 1944, vol. 27, p. 1432,1433
[5] Journal of Chemical Research, 2011, vol. 35, # 5, p. 313 - 316

2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID Suppliers

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10058-38-5, 2-PHENYL-THIAZOLE-5-CARBOXYLIC ACIDRelated Search:

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