4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE

Product Name: 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE
CAS No.: 349-49-5
Chemical Name: 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE
Synonyms: 2-Amino-4-trifluoromethyl-thiazol;4-(trifluoromethyl)thiazol-2-amine;-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE;4-(Trifluoromethyl)-2-Thiazolamine;2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE;4-TRIFLUOROMETHYL-THIAZOLE-2YLAMINE;4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE;2-ThiazolaMine, 4-(trifluoroMethyl)-;2-Amino-4-trifluoromethylthiazole HBr;2-Amino-4-trifluoromethyl-1,3-thiazole
CBNumber: CB9684953
Molecular Formula: C4H3F3N2S
Formula Weight: 168.14
MOL File: 349-49-5.mol

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4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE Property

Melting point:: 60-62°C
Boiling point:: 125-128 °C(Press: 22 Torr)
Density: 1.557±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: crystalline solid
pka: 1.90±0.10(Predicted)
color: Yellow
InChI: InChI=1S/C4H3F3N2S/c5-4(6,7)2-1-10-3(8)9-2/h1H,(H2,8,9)
InChIKey: OVMGTNMCYLZGLS-UHFFFAOYSA-N
SMILES: S1C=C(C(F)(F)F)N=C1N
CAS DataBase Reference: 349-49-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38-43-36
Safety Statements: 26-36/37/39-36/37
RIDADR: UN2811
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00174
Product name: 2-Amino-4-trifluoromethylthiazole hydrobromide
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

TRC

Product number: T792450
Product name: 4-(Trifluoromethyl)-2-thiazolamine
Packaging: 2.5g
Price: $275
Updated: 2021/12/16

Ark Pharm

Product number: P000490123
Product name: 4-(Trifluoromethyl)thiazol-2-amine
Purity: 97%
Packaging: 10g
Price: $386
Updated: 2021/12/16

Oakwood

Product number: 009875
Product name: 4-Trifluoromethyl-thiazole-2ylamine
Packaging: 250mg
Price: $16
Updated: 2021/12/16

Ark Pharm

Product number: P000490123
Product name: 4-(Trifluoromethyl)thiazol-2-amine
Purity: 97%
Packaging: 250mg
Price: $16
Updated: 2021/12/16

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4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE Chemical Properties,Usage,Production

Uses

4-(Trifluoromethyl)-2-thiazolamine can be used to prepare phenethylthiazolylthiourea analogs as HIV-1 reverse transcriptase inhibitors. 4-(Trifluoromethyl)-2-thiazolamine can also be used to synthesize 2-amino benzamide derivatives as allosteric glucokinase activators.

Synthesis

431-35-6

17356-08-0

349-49-5

General procedure for the synthesis of 2-amino-4-trifluoromethylthiazole from 3-bromo-1,1,1-trifluoroacetone and thiourea: Thiourea (4.0 g, 52.3 mmol) and 3-bromo-1,1,1-trifluoropropan-2-one (5.5 mL, 10 g, 52.3 mmol) were added to ethanol (100 mL) and the reaction was heated for 2 hours at 50 °C. After completion of the reaction, it was cooled to room temperature and the reaction solution was concentrated to dryness. The residue was dissolved in water and the pH was adjusted with 2 M NaOH solution to >12. Subsequently, four extractions were performed with ether. The organic extracts were combined, dried with sodium sulfate, filtered and concentrated in vacuum. The resulting crude product was purified by silica gel column chromatography (CH2Cl2 as eluent) to afford 2-amino-4-trifluoromethylthiazole (6.9 g, 79% yield). es/MS m/z 169 (M + 1)+.

References

[1] Patent: WO2008/36579, 2008, A1. Location in patent: Page/Page column 43
[2] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 4, p. 907 - 911
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 1051 - 1053
[4] Journal of Organic Chemistry, 1955, vol. 20, p. 499,505
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 2335 - 2339

4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE Suppliers

China 126 Europe 2 France 1 Germany 7 India 3 Japan 1 Russia 1 Slovakia 1 The Netherlands 1 Ukraine 1 United Kingdom 9 United States 20 Global 173

Zhijiang City Zhou Yuan Yao Biological Technology Co., LTD

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View Lastest Price from 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE manufacturers

Honest Joy Holdings Limited

Product: 4-(trifluoromethyl)thiazol-2-amine 349-49-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.3%
Supply Ability: 100 tons
Release date: 2022-02-18

Career Henan Chemical Co

Product: -TRIFLUOROMETHYL-THIAZOL-2-YLAMINE 349-49-5
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

Career Henan Chemical Co

Product: 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE 349-49-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-03

349-49-5, 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINERelated Search:

4-(trifluoromethyl)thiazol-2-amine

2-Amino-4-trifluoromethyl-1,3-thiazole

4-(TRIFLUOROMETHYL)-1,3-THIAZOL-2-AMINE

4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE

4-TRIFLUOROMETHYL-THIAZOLE-2YLAMINE

2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE

-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE

2-Amino-4-trifluoromethyl-thiazol

2-ThiazolaMine, 4-(trifluoroMethyl)-

2-Amino-4-trifluoromethylthiazole HBr

2-Amino-4-trifluoromethylthiazole hydrobromide

4-(Trifluoromethyl)-2-Thiazolamine

TIANFU-CHEM 349-49-5 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE

4-Trifluoromethyl-thiazol-2ylamine, 95%

349-49-5

C4H3F3N2S

C4H3F3N2SHBr

Amines

Thiazoles, Isothiazoles & Benzothiazoles

LN202107