ChemicalBook > CAS DataBase List > 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE

4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE

Product Name
4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE
CAS No.
349-49-5
Chemical Name
4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE
Synonyms
2-Amino-4-trifluoromethyl-thiazol;4-(trifluoromethyl)thiazol-2-amine;-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE;4-(Trifluoromethyl)-2-Thiazolamine;2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE;4-TRIFLUOROMETHYL-THIAZOLE-2YLAMINE;4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE;2-ThiazolaMine, 4-(trifluoroMethyl)-;2-Amino-4-trifluoromethylthiazole HBr;2-Amino-4-trifluoromethyl-1,3-thiazole
CBNumber
CB9684953
Molecular Formula
C4H3F3N2S
Formula Weight
168.14
MOL File
349-49-5.mol
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4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE Property

Melting point:
60-62°C
Boiling point:
125-128 °C(Press: 22 Torr)
Density 
1.557±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
crystalline solid
pka
1.90±0.10(Predicted)
color 
Yellow
InChI
InChI=1S/C4H3F3N2S/c5-4(6,7)2-1-10-3(8)9-2/h1H,(H2,8,9)
InChIKey
OVMGTNMCYLZGLS-UHFFFAOYSA-N
SMILES
S1C=C(C(F)(F)F)N=C1N
CAS DataBase Reference
349-49-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38-43-36
Safety Statements 
26-36/37/39-36/37
RIDADR 
UN2811
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00174
Product name
2-Amino-4-trifluoromethylthiazole hydrobromide
Purity
Aldrich
Packaging
1g
Price
$216
Updated
2025/07/31
TRC
Product number
T792450
Product name
4-(Trifluoromethyl)-2-thiazolamine
Packaging
2.5g
Price
$275
Updated
2021/12/16
Ark Pharm
Product number
P000490123
Product name
4-(Trifluoromethyl)thiazol-2-amine
Purity
97%
Packaging
10g
Price
$386
Updated
2021/12/16
Oakwood
Product number
009875
Product name
4-Trifluoromethyl-thiazole-2ylamine
Packaging
250mg
Price
$16
Updated
2021/12/16
Ark Pharm
Product number
P000490123
Product name
4-(Trifluoromethyl)thiazol-2-amine
Purity
97%
Packaging
250mg
Price
$16
Updated
2021/12/16
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4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE Chemical Properties,Usage,Production

Uses

4-(Trifluoromethyl)-2-thiazolamine can be used to prepare phenethylthiazolylthiourea analogs as HIV-1 reverse transcriptase inhibitors. 4-(Trifluoromethyl)-2-thiazolamine can also be used to synthesize 2-amino benzamide derivatives as allosteric glucokinase activators.

Synthesis

431-35-6

17356-08-0

349-49-5

General procedure for the synthesis of 2-amino-4-trifluoromethylthiazole from 3-bromo-1,1,1-trifluoroacetone and thiourea: Thiourea (4.0 g, 52.3 mmol) and 3-bromo-1,1,1-trifluoropropan-2-one (5.5 mL, 10 g, 52.3 mmol) were added to ethanol (100 mL) and the reaction was heated for 2 hours at 50 °C. After completion of the reaction, it was cooled to room temperature and the reaction solution was concentrated to dryness. The residue was dissolved in water and the pH was adjusted with 2 M NaOH solution to >12. Subsequently, four extractions were performed with ether. The organic extracts were combined, dried with sodium sulfate, filtered and concentrated in vacuum. The resulting crude product was purified by silica gel column chromatography (CH2Cl2 as eluent) to afford 2-amino-4-trifluoromethylthiazole (6.9 g, 79% yield). es/MS m/z 169 (M + 1)+.

References

[1] Patent: WO2008/36579, 2008, A1. Location in patent: Page/Page column 43
[2] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 4, p. 907 - 911
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 1051 - 1053
[4] Journal of Organic Chemistry, 1955, vol. 20, p. 499,505
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 2335 - 2339

4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE Suppliers

China 126 Europe 2 France 1 Germany 7 India 3 Japan 1 Russia 1 Slovakia 1 The Netherlands 1 Ukraine 1 United Kingdom 9 United States 20 Global 173
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE manufacturers

Honest Joy Holdings Limited
Product
4-(trifluoromethyl)thiazol-2-amine 349-49-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99.3%
Supply Ability
100 tons
Release date
2022-02-18
Career Henan Chemical Co
Product
-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE 349-49-5
Price
US $5.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-12
Career Henan Chemical Co
Product
4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE 349-49-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-03

349-49-5, 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINERelated Search:

4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE 2-Methyl-4-trifluoromethyl-thiazol-5-ylamine 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-CYCLOPENTYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-([4-(TRIFLUOROMETHYL)-1,3-THIAZOL-2-YL]AMINO)-5,6,7,8-TETRAHYDRO-4(3H)-QUINAZOLINONE 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-C& 2-M-TOLYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID 2-ALLYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOHYDRAZIDE ETHYL 2-MORPHOLINO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE 2-CYCLOPROPYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-[3-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE 5-(TRIFLUOROMETHYL)-1-[4-(TRIFLUOROMETHYL)-1,3-THIAZOL-2-YL]-1H-PYRAZOLE-4-CARBOXYLIC ACID 2-ISOPROPYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-(1-PHENYL-ETHYLAMINO)-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID 2-SEC-BUTYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL 5-(TRIFLUOROMETHYL)-1-[4-(TRIFLUOROMETHYL)-1,3-THIAZOL-2-YL]-1H-PYRAZOLE-4-CARBOXYLATE 2-[4-(4-METHOXYPHENYL)PIPERAZINO]-4-(TRIFLUOROMETHYL)-1,3-THIAZOL-3-IUM BROMIDE

  • 4-(trifluoromethyl)thiazol-2-amine
  • 2-Amino-4-trifluoromethyl-1,3-thiazole
  • 4-(TRIFLUOROMETHYL)-1,3-THIAZOL-2-AMINE
  • 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE
  • 4-TRIFLUOROMETHYL-THIAZOLE-2YLAMINE
  • 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE
  • -TRIFLUOROMETHYL-THIAZOL-2-YLAMINE
  • 2-Amino-4-trifluoromethyl-thiazol
  • 2-ThiazolaMine, 4-(trifluoroMethyl)-
  • 2-Amino-4-trifluoromethylthiazole HBr
  • 2-Amino-4-trifluoromethylthiazole hydrobromide
  • 4-(Trifluoromethyl)-2-Thiazolamine
  • TIANFU-CHEM 349-49-5 4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE
  • 4-Trifluoromethyl-thiazol-2ylamine, 95%
  • 349-49-5
  • C4H3F3N2S
  • C4H3F3N2SHBr
  • Amines
  • Thiazoles, Isothiazoles & Benzothiazoles
  • LN202107