TISSUE PLASMINOGEN ACTIVATOR, HUMAN

Product Name: TISSUE PLASMINOGEN ACTIVATOR, HUMAN
CAS No.: 189263-81-8
Chemical Name: TISSUE PLASMINOGEN ACTIVATOR, HUMAN
Synonyms: TISSUE PLASMINOGEN ACTIVATOR;TPA;TPA, HUMAN;1-CHAIN TPA;2-CHAIN TPA;TISSUE PLASMINOGEN ACTIVATOR, HUMAN;TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN;TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN;9,10-Bis[N-(m-tolyl)anilino]anthracene;9,10-Bis[N-(m-tolyl)anilino]anthracene
CBNumber: CB3746518
Molecular Formula: C40H32N2
Formula Weight: 540.7
MOL File: 189263-81-8.mol

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TISSUE PLASMINOGEN ACTIVATOR, HUMAN Property

Melting point:: 262 °C
Boiling point:: 723.8±53.0 °C(Predicted)
Density: 1.194±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: Lyophilized
pka: -0.33±0.50(Predicted)
color: Light yellow to Yellow to Orange

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 1
HS Code: 2921.59.8090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T0831
Product name: Tissue plasminogen activator human
Packaging: 100μG
Price: $512
Updated: 2023/06/20

Sigma-Aldrich

Product number: T0831
Product name: Tissue plasminogen activator human
Packaging: 1MG
Price: $1150
Updated: 2023/06/20

Sigma-Aldrich

Product number: T0831
Product name: Tissue plasminogen activator human
Packaging: 100UG
Price: $426
Updated: 2022/05/15

TCI Chemical

Product number: B4965
Product name: 9,10-Bis[N-(m-tolyl)anilino]anthracene
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $268
Updated: 2024/03/01

TCI Chemical

Product number: B4965
Product name: 9,10-Bis[N-(m-tolyl)anilino]anthracene
Purity: >98.0%(HPLC)
Packaging: 200mg
Price: $78
Updated: 2024/03/01

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TISSUE PLASMINOGEN ACTIVATOR, HUMAN Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

Tissue plasminogen activator has been used in a study to assess treatment risks of intracranial hemorrhage among patients with acute ischemic stroke. Tissue plasminogen activator has also been used in a study to investigate the successful treatment of early thrombosis of HeartWare left ventricular assist devices with intraventricular thrombolytics. Human tissue plasminogen activator has been used to study the effect of tyrosinase-related protein 2 (TRP-2) expression on melanin production in sheep.

General Description

Recombinant tPA (rtPA), alteplase (Activase), is identicalwith endogenous tPA. rtPA lacks a glycosyl residue atAsn184. At one time, rtPA was produced in two-chain formin CHO cultures. Now, large-scale cultures of recombinanthuman melanoma cells in fermenters are used to produce aproduct that is about 80% single-chain rtPA.
Alteplase is used to improve ventricular function followingan acute myocardial infarction, including reducing the incidenceof congestive heart failure and decreasing mortality.The drug is also used to treat acute ischemic stroke aftercomputed tomography (CT) or other diagnostic imaging hasruled out intracranial hemorrhage. rtPA is also used in casesof acute pulmonary thromboembolism and is being investigatedfor unstable angina pectoris.
Alteplase is supplied as powder for injection, and in reconstitutedform (normal saline or 5% dextrose in water) isintended for IV infusion only. The solution expires in 8 hoursat room temperature and must be prepared just before use.

Biochem/physiol Actions

tPA is a potent activator of fibrinolysis and converts plasminogen into plasmin and also initiates cell signaling. The plasminogen activation system may also be associated with degradation of amyloid fibrils. It is also known to mediate inflammatory and extracellular matrix remodeling processes and is predicted to participate in disease progression of intracranial aneurysm indicating brain vascular malformations. Upregulation of the gene is observed in aortic aneurysms.

TISSUE PLASMINOGEN ACTIVATOR, HUMAN Preparation Products And Raw materials

Raw materials

Preparation Products

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TISSUE PLASMINOGEN ACTIVATOR, HUMAN Suppliers

Americas 1 China 51 Europe 3 Germany 2 India 2 Japan 2 Switzerland 1 United Kingdom 2 United States 7 Global 71

TCI (Shanghai) Development Co., Ltd.

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Adamas Reagent, Ltd.

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TCI AMERICA

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Sigma-Aldrich

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189263-81-8, TISSUE PLASMINOGEN ACTIVATOR, HUMANRelated Search:

Tris(acetylacetonato)(1,10-phenanthroline)terbium(III) Bis(8-quinolinolato) zinc 9,10-Bis[N,N-di-(p-tolyl)-amino]anthracene N,N'-Dimethylquinacridone 10-(2-Benzothiazolyl)-2,3,6,7-tetrahydro-1,1,7,7-tetramethyl-1H,5H,11H-(1)benzopyropyrano(6,7-8-I,j)quinolizin-11-one (2,2'-Bipyridine)bis(2-phenylpyridinato)iridium(III) Hexafluorophosphate BIS[2-(2-BENZOXAZOLYL)PHENOLATO]ZINC(II) Quinacridone 9,10-Bis[phenyl(m-tolyl)-amino]anthracene 2-Bromo-9,10-diphenylanthracene Tissue Plasminogen Activator

2-CHAIN TPA

1-CHAIN TPA

Tissue Plasminogen Activator from human melanoma cells

9,10-Bis[N-(m-tolyl)anilino]anthracene

TISSUE PLASMINOGEN ACTIVATOR, HUMANphenyl)-N,N'-diphenyl-

TISSUE PLASMINOGEN ACTIVATOR, HUMAN

TISSUE PLASMINOGEN ACTIVATOR

TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN

TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN

TPA, HUMAN

TPA

9-N,10-N-bis(3-methylphenyl)-9-N,10-N-diphenylanthracene-9,10-diamine

9,10-Bis[<i>N</i>-(<i>m</i>-tolyl)anilino]anthracene

9,10-Anthracenediamine, N9,N10-bis(3-methylphenyl)-N9,N10-diphenyl-

N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-9,10-anthracenediamine

N,N'-Diphenyl-N,N'-di(m-tolyl)-9,10-anthracenediamine

N9,N10-Diphenyl-N9,N10-di-m-tolylanthracene-9,10-diamine

189263-81-8

Serum Related EnzymesEnzymes, Inhibitors, and Substrates

Therapeutic EnzymesProteolytic Enzymes and Substrates

Tissue Plasminogen Activator

Application Index

Proteases&Protein Sequencing

ProteasesApplication Index

Selective Proteolytic Enzymes

Serum Proteins and Related Enzymes