3-FLUORO-4-NITROPYRIDINE-N-OXIDE
Uses- Product Name
- 3-FLUORO-4-NITROPYRIDINE-N-OXIDE
- CAS No.
- 769-54-0
- Chemical Name
- 3-FLUORO-4-NITROPYRIDINE-N-OXIDE
- Synonyms
- 3-fluoro-4-nitro-, 1-oxide;FLUORO-4-NITROPYRIDINE N-OXIDE;3-fluoro-4-nitro-1-pyridin-1-one;3-FLUORO-4-NITROPYRIDINE-N-OXIDE;Pyridine, 3-fluoro-4-nitro-, 1-oxide;3-Fluoro-4-nitropyridine-N-oxide 98%;3-fluoro-4-nitropyridin-1-ium-1-olate;3-fluoro-4-nitro-1-oxidopyridin-1-ium;3-fluoro-4-nitro-1$l^{5}-pyridin-1-one;3-FLUORO-4-NITROPYRIDINE-N-OXIDE ISO 9001：2015 REACH
- CBNumber
- CB3749847
- Molecular Formula
- C5H3FN2O3
- Formula Weight
- 158.09
- MOL File
- 769-54-0.mol
3-FLUORO-4-NITROPYRIDINE-N-OXIDE Property
- Melting point:
- 122℃
- Boiling point:
- 417.9±25.0 °C(Predicted)
- Density
- 1.56
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- pka
- -2.08±0.10(Predicted)
- form
- woolen crystalline needles
- color
- Lemon, tiny
- InChI
- InChI=1S/C5H3FN2O3/c6-4-3-7(9)2-1-5(4)8(10)11/h1-3H
- InChIKey
- QHWIGULJOZAPAQ-UHFFFAOYSA-N
- SMILES
- C1[N+]([O-])=CC=C([N+]([O-])=O)C=1F
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F597693
- Product name
- 3-Fluoro-4-nitropyridine-N-oxide
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- PC53338
- Product name
- 3-Fluoro-4-nitropyridine-N-oxide
- Purity
- 98%
- Packaging
- 5g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- J94918
- Product name
- 3-Fluoro-4-nitropyridine-N-oxide
- Packaging
- 5g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- 073104
- Product name
- 3-Fluoro-4-nitropyridine N-oxide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $51
- Updated
- 2021/12/16
- Product number
- 4H54-3-0U
- Product name
- 3-Fluoro-4-nitropyridine N-oxide
- Packaging
- 5G
- Price
- $56
- Updated
- 2021/12/16
3-FLUORO-4-NITROPYRIDINE-N-OXIDE Chemical Properties,Usage,Production
Uses
3-Fluoro-N-oxy-4-nitropyridine is a heterocyclic derivative and an important intermediate for the synthesis of novel pesticides and pharmaceuticals containing pyridine groups.
Synthesis
695-37-4
769-54-0
Example 19 Preparation of 3-fluoro-4-nitropyridine N-oxide (3-3): refer to the literature method of Bellas and Suschitzky (Chem. Soc., 1965, 2096-2100). Fuming nitric acid (21 mL) was added slowly and dropwise at 120°C to a stirred solution of 3-fluoropyridine N-oxide (3-2) (10.4 g, 90 mmol) dissolved in sulfuric acid (52 mL) over a period of 1 hour. After the dropwise addition, the reaction mixture was continued to be stirred at 120 °C for 3 hours. Subsequently, the reaction solution was cooled to room temperature and carefully poured into ice (300 mL). The pH of the mixture was adjusted to 7 with 20% sodium hydroxide solution, followed by extraction with chloroform. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue was recrystallized by mixed ether/hexane solvent to give a light yellow solid product (7.5 g, 51% yield).1H NMR (400 MHz, CDCl3): δ 8.05 (m, 2H), 8.22 (m, 1H).
References
[1] Patent: US2003/92679, 2003, A1
[2] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 3, p. 333 - 338
[3] Patent: US2007/167442, 2007, A1. Location in patent: Page/Page column 42
[4] Patent: US2004/14742, 2004, A1. Location in patent: Page 32
[5] Patent: WO2013/184757, 2013, A1. Location in patent: Page/Page column 85; 86
3-FLUORO-4-NITROPYRIDINE-N-OXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-4-NITROPYRIDINE-N-OXIDE manufacturers
- Product
- 3-FLUORO-4-NITROPYRIDINE-N-OXIDE 769-54-0
- Price
- US $0.00-0.00/G
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2025-09-05
- Product
- 3-Fluoro-4-nitropyridine-N-oxide 769-54-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 5000KGS
- Release date
- 2024-11-09
- Product
- 3-FLUORO-4-NITROPYRIDINE-N-OXIDE 769-54-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-27