ChemicalBook > CAS DataBase List > 1H-1,2,4-Triazole-3,5-diamine

1H-1,2,4-Triazole-3,5-diamine

Product Name
1H-1,2,4-Triazole-3,5-diamine
CAS No.
1455-77-2
Chemical Name
1H-1,2,4-Triazole-3,5-diamine
Synonyms
3,5-DIAMINO-1,2,4-TRIAZOLE;GUANAZOLE;4H-1,2,4-TRIAZOLE-3,5-DIAMINE;nsc1895;MC 51762;NSC 1895;NCI-C04819;TIMTEC-BB SBB004371;Guanazole (VAN) (8CI);3,5-diamino-s-triazol
CBNumber
CB3756001
Molecular Formula
C2H5N5
Formula Weight
99.09
MOL File
1455-77-2.mol
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1H-1,2,4-Triazole-3,5-diamine Property

Melting point:
202-205 °C (lit.)
Boiling point:
473.7±28.0 °C(Predicted)
Density 
1.686±0.06 g/cm3(Predicted)
refractive index 
1.7330 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: clear to hazy
form 
powder
pka
12.10±0.40(Predicted)
color 
white
Water Solubility 
Soluble in water.
BRN 
112467
Stability:
Stability Air sensitive. Reacts with acids and oxidizing agents.
InChIKey
PKWIYNIDEDLDCJ-UHFFFAOYSA-N
CAS DataBase Reference
1455-77-2(CAS DataBase Reference)
NIST Chemistry Reference
3,5-Diamino-1,2,4-triazole(1455-77-2)
EPA Substance Registry System
Guanazole (1455-77-2)
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Safety

Hazard Codes 
Xn,Xi,C
Risk Statements 
22-34
Safety Statements 
36/37-45-36/37/39-27-26
WGK Germany 
3
RTECS 
XZ4535000
TSCA 
Yes
HS Code 
29339990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D26202
Product name
3,5-Diamino-1,2,4-triazole
Purity
98%
Packaging
25g
Price
$189
Updated
2024/03/01
Sigma-Aldrich
Product number
D26202
Product name
3,5-Diamino-1,2,4-triazole
Purity
98%
Packaging
100g
Price
$683
Updated
2024/03/01
TCI Chemical
Product number
D2587
Product name
3,5-Diamino-1,2,4-triazole
Purity
>97.0%(T)
Packaging
5g
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
D2587
Product name
3,5-Diamino-1,2,4-triazole
Purity
>97.0%(T)
Packaging
25g
Price
$128
Updated
2024/03/01
Alfa Aesar
Product number
B22775
Product name
3,5-Diamino-1,2,4-triazole, 98+%
Packaging
5g
Price
$33.65
Updated
2024/03/01
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1H-1,2,4-Triazole-3,5-diamine Chemical Properties,Usage,Production

Chemical Properties

colourless crystals or faintly yellow powder

Uses

3,5-Diamino-1,2,4-triazole is used as an inhibitor of DNA synthesis. It also serves as an antitumor agents in the treatment of epigenetically-based diseases. It acts as a corrosion inhibitor for copper.

Definition

ChEBI: An aromatic amine that is 1,2,4-triazole substituted at positions 3 and 5 by amino groups.

General Description

Colorless crystals.

Air & Water Reactions

1H-1,2,4-Triazole-3,5-diamine is sensitive to air. Dust can be explosive when suspended in air at specific concentrations. Water soluble.

Reactivity Profile

The triazoles, of which 1H-1,2,4-Triazole-3,5-diamine is a member, are a group of highly explosive materials that are sensitive to heat, friction, and impact. Sensitivity varies with the type of substitution to the triazole ring. The amine substituted derivatives, 1H-1,2,4-Triazole-3,5-diamine, tend not to be explosion sensitive. Metal chelated and halogen substitution of the triazol ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives. 1H-1,2,4-Triazole-3,5-diamine forms salts readily with acids.

Health Hazard

SYMPTOMS: 1H-1,2,4-Triazole-3,5-diamine is stable under normal laboratory conditions.

Fire Hazard

Flash point data for 1H-1,2,4-Triazole-3,5-diamine are not available. 1H-1,2,4-Triazole-3,5-diamine is probably combustible.

Safety Profile

Human systemic effects by intravenous route: leukopenia (reduced white blood cell count) and thrombo cytopenia (reduced blood platelet count). Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The triazole crystallises from water or EtOH. [Beilstein 26 III/IV 1161.]

1H-1,2,4-Triazole-3,5-diamine Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-1,2,4-Triazole-3,5-diamine Suppliers

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View Lastest Price from 1H-1,2,4-Triazole-3,5-diamine manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
1H-1,2,4-Triazole-3,5-diamine 1455-77-2
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-19
Hebei Mojin Biotechnology Co., Ltd
Product
1H-1,2,4-Triazole-3,5-diamine 1455-77-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-11
Hebei Guanlang Biotechnology Co., Ltd.
Product
1H-1,2,4-Triazole-3,5-diamine 1455-77-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2023-04-06

1455-77-2, 1H-1,2,4-Triazole-3,5-diamineRelated Search:

1H-1,2,4-Triazole-3,5-diamine 3,5-DIAMINO-1,2,4-TRIAZOLE,3,5-diamino-1,3,5-triazole,3 5-DIAMINO-1 2 4-TRIAZOLE 98% 1,2,4-Triazole 3,5,7-TRIAMINO-1,2,4-TRIAZOLO[4,3-A]-1,3,5-TRIAZINE N3-(4-CHLOROPHENYL)-1H-1,2,4-TRIAZOLE-3,5-DIAMINE N3,N3,N5,N5-TETRAMETHYL-1-([3-(TRIFLUOROMETHYL)PHENYL]SULFONYL)-1H-1,2,4-TRIAZOLE-3,5-DIAMINE 1-phenyl-1H-1,2,4-triazole-3,5-diamine 1-(4-FLUOROBENZYL)-N3,N3,N5,N5-TETRAMETHYL-1H-1,2,4-TRIAZOLE-3,5-DIAMINE 1-(2,6-DICHLOROBENZYL)-N3,N3,N5,N5-TETRAMETHYL-1H-1,2,4-TRIAZOLE-3,5-DIAMINE 1H-1,2,4-Triazole-3,5-diamine,N-propyl-(9CI) N-phenyl-1H-1,2,4-triazole-3,5-diamine 1-[(4-METHOXYPHENYL)SULFONYL]-N3,N3,N5,N5-TETRAMETHYL-1H-1,2,4-TRIAZOLE-3,5-DIAMINE N3,N3,N5,N5-TETRAMETHYL-1-(4-METHYLBENZYL)-1H-1,2,4-TRIAZOLE-3,5-DIAMINE 4H-1,2,4-Triazole-3,4-diamine,5-ethyl-N-methyl-N-(phenylmethylene)-(9CI) 5-METHYL-1,2,4-TRIAZOLE-3,4-DIAMINE 4H-1,2,4-Triazole-3,4-diamine 1-(4-BROMOBENZYL)-N3,N3,N5,N5-TETRAMETHYL-1H-1,2,4-TRIAZOLE-3,5-DIAMINE 7-(4-BROMOPHENYL)-2-MORPHOLINO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE

  • 3,5-DiaMino-1,2,4-triazole, 98% 25GR
  • 3,5-Diamino-1H-1,2,4-triazole, Guanazole
  • 1,2,4-triazolidine-3,5-diiMine
  • Guanazole SynonyMs 1H-1,2,4-Triazole-3,5-diaMine
  • (5-amino-2H-1,2,4-triazol-3-yl)amine
  • Guanazole (VAN) (8CI)
  • 4H-1,2,4-TRIAZOLE-3,5-DIAMINE
  • 3-AMINO-1H-1,2,4-TRIAZOL-5-YLAMINE
  • 3,5-DIAMINO-1,2,4-TRIAZOLE
  • 3,5-DIAMINO-1H-1,2,4-TRIAZOLE
  • 1,2,4-Triazolidine, 3,5-diimino-
  • 3,5-diamino-s-triazol
  • 3,5-Diamino-s-triazole
  • MC 51762
  • NCI-C04819
  • NSC 1895
  • nsc1895
  • s-Triazole, 3,5-diamino-
  • GUANAZOLE
  • TIMTEC-BB SBB004371
  • 1H-1,2,4-TRIAZOLE-3,5-DIAMINE
  • 3,5-Diamino-1,2,4-triazole (Guanazole)
  • 1H-1,2,4-Triazole-3,5-diamine (Guanazole)
  • GUANETIDINEHEMISULPHATE
  • 3,5-DIAMINO-1,2,4-TRIAZOLE, 98+%
  • 2,3-Diamino-1H-1,2,4-triazole
  • Guanazole 3,5-Diamino-1,2,4-triazole (Guanazole) 3,5-Diamino-1H-1,2,4-triazole 1H-1,2,4-triazole-3,5-diamine
  • 3,5-Diamino-1,2,4-triazole, 98%, for synthesis
  • 3,5-Diamino-1,2,4-triazole&gt
  • 1455-77-2
  • 1455-72-2
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