Bromadiolone Property

Melting point:

200-210°

Boiling point:

723.4±60.0 °C(Predicted)

Density 

1.3243 (rough estimate)

vapor pressure 

2 x l0^-6Pa (20 °C)

refractive index 

1.4490 (estimate)

storage temp. 

-20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml

Water Solubility 

19 mg l^-1 (20 °C)

form 

Powder

pka

4.04(at 21℃)

Merck 

13,1366

BRN 

1335336

LogP

7.480 (est)

CAS DataBase Reference

28772-56-7(CAS DataBase Reference)

EPA Substance Registry System

Bromadiolone (28772-56-7)

Safety

Hazard Codes 

T+,N

Risk Statements 

27/28-50

Safety Statements 

28-36/37/39-45-61

RIDADR 

UN 2811

WGK Germany 

3

RTECS 

GN4934700

HazardClass 

6.1(a)

PackingGroup 

I

Hazardous Substances Data

28772-56-7(Hazardous Substances Data)

Toxicity

LD50 in rats, mice (mg/kg): 1.125, 1.75 orally (Grand)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Bromadiolone Chemical Properties,Usage,Production

Description

Bromadiolone is used to control rodents around buildings, inside transport vehicles and sewers. It is often formulated as meal bait, rat and mouse bait ready-to-use place packs, paraffinized pellets and blocks.

Chemical Properties

Bromadiolone is white to off-white (yellowish) powder.

Occurrence

Boldo is an evergreen found in Chile, Peru, and Morocco.

Uses

Bromadiolone is an anticoagulant rodenticide used on non-crop areas.

Uses

Rodenticide.

Uses

Bromadiolone is used for the control of rats and mice.

Definition

ChEBI: Bromadiolone is a diarylheptanoid.

General Description

Yellowish powder. Used as an anticoagulant rodenticide.

Health Hazard

The compound is toxic by oral exposure.

Fire Hazard

(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution. When heated to decomposition, Bromadiolone emits toxic fumes of bromine containing compounds.

Agricultural Uses

Rodenticide: Bromadiolone is used as an anticoagulant rodenticide and used as bait for rodent control against house mice, roof rats and warfarin-resistant Norway rats. It is also authorized by USDA for use in official establishments operating under the Federal meat, poultry, shell egg grading and egg products inspection program.

Trade name

BOLDO®; BOOT HILL®; BROMONE®; CANADIEN 2000®; CONTRAC®; HAWK®; LM- 637®; MAKI®; RAT ARREST®; RAT FREE®; RATIMUS®; RENTOKIL DEADLINE®; SLAYMOR®; SUPER-CAID®; SUPER-ROZOL®; SUP'ORATS®; TERMUS®

Potential Exposure

Bromadiolone is used as an anticoagulant rodenticide. It is bait for rodent control used against house mice, roof rats, warfarin-resistant Norway rats. It is also authorized by USDA for use in official establishments operating under the federal meat, poultry, shell egg grading, and egg products inspection program. May be used as a drug.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit. Keepvictim quiet and maintain normal body temperature. Effectsmay be delayed; keep victim under observation.

Environmental Fate

Bromadiolone belongs to second generation of long-acting anticoagulant rodenticide. It acts by interfering with the prothrombin synthesis by blocking the regeneration of vitamin K dependant proteins in the liver and thereby disrupting the clotting mechanisms and increasing the tendency to hemorrhages and subsequent death.

Metabolic pathway

Metabolism in the rat is very slow and products other than a conjugate of the parent compound have not been identified. Biodegradation in soil and plants has not been reported.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with bromadiolone you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area.

Shipping

UN3027 Coumarin derivative pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1—Poisonous materials. UN3026 Coumarin derivative pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1—Poisonous materials.

Degradation

Bromadiolone is a stable compound. It is a weak acid.

Toxicity evaluation

Bromadiolone may be released into the environment through various waste streams and its use. If released to air, it will exist in the particulate phase in the ambient atmosphere and will be removed by dry and wet deposition. In soil, it is not persistent under aerobic conditions (half-life is 14 days) and is usually immobile except in soils of low organic matter and clay, such as sand.
When released to water, it adsorbs to suspended solids and sediment. Bromadiolone is stable to hydrolysis at pH 5, 7, and 9. Two major degradates, [1,3-diphenyl-5(40-bromobiphenyl) pentane-1-ol] and [1,3-diphenyl-5(40-bromobiphenyl) pentane-1,5-diol], are detected in the aerobic soil metabolism study.
Bromadiolone is bioaccumulated in edible and nonedible tissues in bluegill sunfish at the bioaccumulation concentration factors of 160X and 1658X. It was also detected in birds.