ChemicalBook > CAS DataBase List > 2'-Hydroxychalcone

2'-Hydroxychalcone

Product Name
2'-Hydroxychalcone
CAS No.
1214-47-7
Chemical Name
2'-Hydroxychalcone
Synonyms
2-HYDROXYCHALC;O-CINNAMOYLPHENOL;6'-Hydroxychalcone;2'-HYDROXYCHALCONE;2'-hydroxychalcone;HYDROXYCHALCONE, 2'-;2'-HYDROXYCHALCONE 98%;2-HYDROXYBENZALACETOPHENONE;2-Hydroxyphenylstyryl ketone;2'-HYDROXYCHALCONE 1214-47-7
CBNumber
CB3771305
Molecular Formula
C15H12O2
Formula Weight
224.25
MOL File
1214-47-7.mol
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2'-Hydroxychalcone Property

Melting point:
86-88 °C(lit.)
Boiling point:
396.6±42.0 °C(Predicted)
Density 
1.191±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Store below +30°C.
pka
7.77±0.30(Predicted)
form 
Solid
color 
Light yellow to yellow
BRN 
976324
LogP
4.000 (est)
CAS DataBase Reference
1214-47-7(CAS DataBase Reference)
EPA Substance Registry System
2-Propen-1-one, 1-(2-hydroxyphenyl)-3-phenyl- (1214-47-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
UD5579400
F 
8
Autoignition Temperature
280 °C
TSCA 
Yes
HS Code 
29145090
Toxicity
mammal (species unspecified),LD50,unreported,620mg/kg (620mg/kg),Pharmaceutical Chemistry Journal Vol. 20, Pg. 406, 1986.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14776
Product name
1-(2-Hydroxyphenyl)-3-phenyl-2-propenone
Purity
for synthesis
Packaging
25g
Price
$69.8
Updated
2024/03/01
Sigma-Aldrich
Product number
S449725
Product name
2'-HYDROXYCHALCONE
Purity
Aldrich
Packaging
250mg
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14776
Product name
1-(2-Hydroxyphenyl)-3-phenyl-2-propenone
Purity
for synthesis
Packaging
100g
Price
$216
Updated
2024/03/01
TCI Chemical
Product number
H0385
Product name
2'-Hydroxychalcone
Purity
>98.0%(HPLC)
Packaging
25g
Price
$68
Updated
2021/12/16
Alfa Aesar
Product number
L13937
Product name
2'-Hydroxychalcone, 98+%
Packaging
5g
Price
$32.8
Updated
2024/03/01
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2'-Hydroxychalcone Chemical Properties,Usage,Production

Chemical Properties

Yellow needle-like crystals (ethanol). Melting point 88-89°C.

Uses

2'-Hydroxychalcone can be used as intermediates in drug synthesis, such as the preparation of flavonol compounds. Flavonols are widely distributed in nature as secondary metabolites in living organisms, and they have a wide variety of physiological activities, mainly in the cardiovascular system, antiviral, anti-inflammatory and antitumor effects.

Definition

ChEBI: 2'-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'. It has a role as an anti-inflammatory agent. It is a member of phenols and a member of chalcones. It derives from a trans-chalcone.

Preparation

Synthesis of 2'-hydroxychalcone: add 30 ml of 20% (V/V) ethanol and (11.06 mmol) sodium hydroxide in a 50 mL single mouth flask, stir for 0.5 h at room temperature and then add substituted 2-Hydroxyacetophenone (1.66 mmol) and benzaldehyde (1.66 mmol), stir for 18 h at room temperature, TLC monitoring until the new point produces raw material point no longer changes, stop the reaction Then the reaction was poured into water, stirred while adjusting the pH value to acidic with 6 mol/L hydrochloric acid, the reaction was filtered, the filter cake was obtained, rinsed twice with pure water, and 2'-hydroxychalcone was obtained by silica gel column chromatography [V(petroleum ether):V(ethyl acetate) = 5:1] in 85% yield.

2'-Hydroxychalcone Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Hydroxychalcone Suppliers

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View Lastest Price from 2'-Hydroxychalcone manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
2'-Hydroxychalcone 1214-47-7
Price
US $85.00-850.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-01
Wuhan Boyuan Import & Export Co., LTD
Product
2'-Hydroxychalcone 1214-47-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
500tons
Release date
2021-07-09
Henan Fengda Chemical Co., Ltd
Product
2'-HYDROXYCHALCONE 1214-47-7
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30

1214-47-7, 2'-HydroxychalconeRelated Search:

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  • 2-HydroxychalconeQ: What is 2-Hydroxychalcone Q: What is the CAS Number of 2-Hydroxychalcone Q: What is the storage condition of 2-Hydroxychalcone Q: What are the applications of 2-Hydroxychalcone
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