ILOPROST

Product Name: ILOPROST
CAS No.: 78919-13-8
Chemical Name: ILOPROST
Synonyms: zk36374;LLOPROST;Ilomedin;Endoprost;CILOPROST;Iloprost Na;iloprostaglandin;Iloprost (Ciloprost;1h)-pentalenylidene)-;(16r,s)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandini(sub2)
CBNumber: CB3775439
Molecular Formula: C22H32O4
Formula Weight: 360.49
MOL File: 78919-13-8.mol

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ILOPROST Property

Boiling point:: 539.2±50.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in methyl acetate
form: film
pka: 4.77±0.10(Predicted)
color: colorless
Stability:: Light Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H311Toxic in contact with skin

H331Toxic if inhaled

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1651
Product name: Iloprost
Purity: ≥98% (HPLC)
Packaging: 1MG
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1651
Product name: Iloprost
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $543
Updated: 2024/03/01

Cayman Chemical

Product number: 18215
Product name: Iloprost
Purity: ≥97%
Packaging: 500μg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 18215
Product name: Iloprost
Purity: ≥97%
Packaging: 1mg
Price: $236
Updated: 2024/03/01

Cayman Chemical

Product number: 18215
Product name: Iloprost
Purity: ≥97%
Packaging: 5mg
Price: $1010
Updated: 2024/03/01

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ILOPROST Chemical Properties,Usage,Production

Description

Iloprost is a stable epoprostenol derivative which acts as an inhibitor of platelet aggregation and is recommended for the treatment of peripheral vascular diseases. The compound was shown to be a potent agonist at PGE₂-sensitive and prostacyclin-sensitive receptors in animal studies. Iloprost is administered by IV infusion and has been reported to have beneficial effects in Buerger's and Raynaud's diseases as well as peripheral artery occlusive disease.

Chemical Properties

Colourless Oil

Chemical Properties

Quinone exists as a large, yellow, monoclinic prism with an irritating odor. Quinone is extensively used in the dye, textile, chemical, tanning, and cosmetic industries. In chemical synthesis for hydroquinone and other chemicals, quinone is used as an intermediate. It is also used in the manufacturing industries and chemical laboratories associated with protein fi ber, photographic fi lm, hydrogen peroxide, and gelatin making.

Originator

Schering AG (Germany)

Uses

A synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud''s phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time.

Definition

ChEBI: A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R /stereo>)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.

brand name

Ventavis (Schering);Iiomedin.

Health Hazard

Exposures to quinine vapor are highly irritating to the eyes and may be followed by corneal opacities, structural changes in the cornea, and loss of vision. Solid quinone may produce discoloration, severe irritation, swelling, and form papules and vesicles.

Biological Activity

Prostacyclin (PGI 2 ) analog that binds with high affinity to IP, EP 1 and EP 3 receptors (K i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP 1 , EP 3 , EP 4 , FP, DP, EP 2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC 50 values are 0.24, 0.71 and 1.07 nM respectively).

Biochem/physiol Actions

Iloprost is used to treat children with PH (pulmonary hypertension) after the surgery to clear CHD (congenital heart disease). In transplant patients, this prostacyclin analogue is used to inhibit renal dysfunction. Iloprost performs various functions like vasodilatation and cytoprotection. It has higher stability than prostacyclin.

ILOPROST Preparation Products And Raw materials

Raw materials

Iloprost

Preparation Products

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ILOPROST Suppliers

Canada 1 China 114 Europe 2 Germany 2 Hungary 1 India 5 United Kingdom 2 United States 17 Global 144

Chemvon Biotechnology Co., Ltd

Tel: 021-50790412
Fax: +86-21-50790419
Email: info@chemvon.com
Country: China
ProdList: 371
Advantage: 57

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 18502762009
Email: 721846333@qq.com
Country: China
ProdList: 2446
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Shanghai Hanhong Scientific Co.,Ltd.

Tel
Country: China
ProdList: 42982
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5700
Advantage: 66

China Nobel Chem Co., Limited

Tel: +86(0)21 60484900
Fax: +86(0)21 60484900
Country: China
ProdList: 764
Advantage: 50

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View Lastest Price from ILOPROST manufacturers

Dideu Industries Group Limited

Product: ILOPROST 78919-13-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-06-11

Career Henan Chemical Co

Product: ILOPROST 78919-13-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-07-09

78919-13-8, ILOPROSTRelated Search:

2,6-dichloro-4-aminophenol iloprost 15(R)-ILOPROST [3H]ILOPROST ILOPROST iloprost phenacyl ester

(16r,s)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandini(sub2)

LLOPROST

1h)-pentalenylidene)-

pentanoicacid,5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(

zk36374

6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID

Endoprost

Ilomedin

(5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoicacid

iloprostaglandin

(1S,2R,3R,5S)-7-[(E)-4-Carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-Methyl-6-octyn-1-enyl]-bicyclo[3.3.0]octane

(5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-Methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic Acid

Iloprost Na

Pentanoic acid,5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-Methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]-,(5E)-

CILOPROST

5-[Hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene]pentanoic acid

(E)-5-((3aS,4R,5R,6aS)-5-hydroxy-4-((3S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid

Iloprost (Ciloprost

78919-13-8

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