ChemicalBook > CAS DataBase List > VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS

VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS

Product Name: VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS
CAS No.: 106021-96-9
Chemical Name: VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS
Synonyms: Sclavo peptide;IL-1B (163-171) (HUMAN);interleukin-1beta(163-171;IL-1BETA (163-171) (HUMAN);INTERLEUKIN-1B (163-171) (HUMAN);b-Interleukin I (163-171), human;β-Interleukin I (163-171), human;Interleukin-1β (163-171) (human);β-Interleukin I (163-171), human;VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS
CBNumber: CB3776638
Molecular Formula: C39H64N12O19
Formula Weight: 1004.99
MOL File: 106021-96-9.mol

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VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS Property

Boiling point:: 1682.6±65.0 °C(Predicted)
Density: 1.419±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: insoluble in EtOH; ≥100.4 mg/mL in DMSO; ≥24.75 mg/mL in H2O
form: solid
pka: 3.14±0.10(Predicted)
color: white
biological source: synthetic
Water Solubility: water: soluble 1mg/mL, clear, colorless

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A1026
Product name: β-InterleukinI(163-171),human
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ApexBio Technology

Product number: A1026
Product name: β-InterleukinI(163-171),human
Packaging: 10mg
Price: $100
Updated: 2021/12/16

ApexBio Technology

Product number: A1026
Product name: β-InterleukinI(163-171),human
Packaging: 25mg
Price: $140
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0009164
Product name: BETA-INTERLEUKIN I(163-171)-HUMAN
Purity: 95.00%
Packaging: 1MG
Price: $612.15
Updated: 2021/12/16

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VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS Chemical Properties,Usage,Production

Uses

β-Interleukin I (163-171), human, an immunostimulatory fragment of human IL-1β peptide, is a T cell activator. β-Interleukin I (163-171), human is not an IL-1R-binding domain of IL-1β. β-Interleukin I (163-171), human is a potent adjuvant that enhances the immune response in a variety of exptl. situations[1][3][4].

Biological Activity

β-interleukin i (163-171), human(c39h64n12o19), a peptide with the sequence val-gln-gly-glu-glu-ser-asn-asp-lys, mw= 1005. interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). interleukin 1 alpha and interleukin 1 beta (il-1 alpha and il-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.interleukin-1 beta (il-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the il1b gene. il-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). cytosolic thiol protease cleaves the product to form mature il-1β. il-1β is a member of the interleukin 1 cytokine family. this cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.figure1 formula of b-interleukin i (163-171), humanfigure2 structure of b-interleukin i

Biochem/physiol Actions

IL1B (interleukin 1 β) is an immune-activating cytokine. In presence of infection or cell stress, it gets converted into active mature form.

in vivo

β-Interleukin I (163-171), human (50 μg, daily, a poorly immunogenic fibrosarcoma (CE-2) of BALB/c mice model) induces a consistent but limited inhibition of tumor growth^[2].
β-Interleukin I (163-171), human (1 μmole/kg, i.v.) together with the T-dependent antigen SRBC increases the primary immune response against the antigen^[3].

References

1. Contassot E, Beer HD, French LE (2012). "Interleukin-1, inflammasomes, autoinflammation and the skin". Swiss Med Wkly 142: w135902. Matzinger P (2012). "The evolution of the danget theory. Interview by Lauren Constable, Commissioning Editor". Expert Rev Clin Immunol 8 (4): 311-7.3. Sahoo M, Ceballos-Olvera I, del Barrio L, Re F (2011). "Role of the inflammasome, IL-1β, and IL-18 inbacterial infections". ScientificWorldJournal 11: 2037-50.

VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS Preparation Products And Raw materials

Raw materials

Preparation Products

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106021-96-9, VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYSRelated Search:

ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU IL-1β (208-240) (human) IL-1β (178-207) (human) IL-1α (223-250) (human) VAL-GLN Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH H-GLY-ASP-GLY-OH L-LYSINE ACETATE SALT H-ASP-LYS-OH VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS

IL-1BETA (163-171) (HUMAN)

IL-1B (163-171) (HUMAN)

H-VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS-OH

INTERLEUKIN-1BETA FRAGMENT 163-171 HUMAN

INTERLEUKIN-1BETA (163-171) (HUMAN)

INTERLEUKIN-1B (163-171) (HUMAN)

BETA-INTERLEUKIN I (163-171), HUMAN

VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS

interleukin-1beta(163-171

interleukin-1B fragment 163-171 human

interleukin-1β fragment 163-171 human

b-Interleukin I (163-171), human

β-Interleukin I (163-171), human

IL-1β (163-171) (human)|β-Interleukin I (163-171),human

L-Lysine, L-valyl-L-glutaminylglycyl-L-α-glutamyl-L-α-glutamyl-L-seryl-L-asparaginyl-L-α-aspartyl-

Sclavo peptide

Interleukin-1β (163-171) (human)

IL-1beta (163-171) (human) trifluoroacetate salt

Interleukin I Beta (163-171) (Human)

β-Interleukin I (163-171), human

106021-96-9

C39H64N12O19

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Interleukins (IL)

IL-1 and Receptors

Cytokines, Growth Factors and Hormones

Cytokines and Growth Factors

Cytokine/Growth FactorStem Cell Differentiation

CytokinesCytokines and Growth Factors

CytokinesStem Cell Expansion

IL-1 and ReceptorsObesity Research

Interleukin-1 (IL-1)

Cytokines Growth Factors and Hormones (Obesity)

Cytokines/Growth Factors/Chemokines

Hematopoietic Stem Cell Biology

Hematopoietic Stem Cell Expansion/Differentiation

Immunology

peptides

Interleukins (IL)