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H-CYS-4-ABZ-MET-OH

Product Name
H-CYS-4-ABZ-MET-OH
CAS No.
156707-43-6
Chemical Name
H-CYS-4-ABZ-MET-OH
Synonyms
FTI II;FTASE INHIBITOR II;H-CYS-4-ABZ-MET-OH;FTase Inhibitor II(TFA salt);CYSTEINE-(4-AMINOBENOZYL)METHIONINE;N-[4-[[(2R)-2-Amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine;L-Methionine,N-[4-[[(2R)-2-aMino-3-Mercapto-1-oxopropyl]aMino]benzoyl]-;(2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]benzoyl]amino]-4-methylsulfanylbutanoic acid
CBNumber
CB3777453
Molecular Formula
C15H21N3O4S2
Formula Weight
371.47
MOL File
156707-43-6.mol
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H-CYS-4-ABZ-MET-OH Property

Boiling point:
700.6±60.0 °C(Predicted)
Density 
1.363±0.06 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
≤25mg/ml in
pka
3.46±0.10(Predicted)
form 
crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16607
Product name
FTase Inhibitor II
Purity
≥80%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
16607
Product name
FTase Inhibitor II
Purity
≥80%
Packaging
5mg
Price
$168
Updated
2024/03/01
TRC
Product number
F810350
Product name
FTaseInhibitorII
Packaging
1mg
Price
$45
Updated
2021/12/16
ApexBio Technology
Product number
C3203
Product name
FTaseInhibitorII
Packaging
5mg
Price
$189
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC109033
Product name
H-Cys-4-Abz-Met-OH
Packaging
10mg
Price
$273
Updated
2021/12/16
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H-CYS-4-ABZ-MET-OH Chemical Properties,Usage,Production

Uses

FTase Inhibitor II acts as a cell permeable analog of farnesyl pyrophosphate (FPP) that potently inhibits FTase. Possible cancer therapeutic agent

Biological Activity

ftase inhibitor ii is a potent farnesyl transferase inhibitor.protein prenylation is reported as a key mechanism by which functional association of proteins to membranes is mediated. ras proteins that are regulators of cell proliferation and differentiation are among the proteins undergoing farnesylation.

in vitro

previous study found that cells were treated with ftase inhibitor ii and two ggtase inhibitors (ggti-286 and ggti-2147) and the results showed that there was no change in cell growth in the presence of these inhibitors, even when 100 μm of the drugs were added to the culture. in addition, when cells were treated with a combination of ggti-2147 and ftase inhibitor ii, ranging from 0.1 nm to 100 μm, cell growth was not affected. additionally, in the presence of both 50 μm ftase inhibitor ii and 50 μm ggti-2147, the ftase and ggtase i enzyme activities were abolished [1].

References

[1] v. manne, c. s. ricca, j. g. brown, et al. ras farnesylation as a target for novel antitumor agents: potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase. drug development research 34, 121-137 (1995).

H-CYS-4-ABZ-MET-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-CYS-4-ABZ-MET-OH Suppliers

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9980
Advantage
55
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4840
Advantage
58
Nanjing NingFan Pharm-Tech CO. LTD.
Tel
17368696818
Country
China
ProdList
1984
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6756
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58

156707-43-6, H-CYS-4-ABZ-MET-OHRelated Search:


  • H-CYS-4-ABZ-MET-OH
  • FTASE INHIBITOR II
  • CYSTEINE-(4-AMINOBENOZYL)METHIONINE
  • L-Methionine,N-[4-[[(2R)-2-aMino-3-Mercapto-1-oxopropyl]aMino]benzoyl]-
  • (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]benzoyl]amino]-4-methylsulfanylbutanoic acid
  • FTI II
  • N-[4-[[(2R)-2-Amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine
  • FTase Inhibitor II(TFA salt)
  • 156707-43-6