ChemicalBook > CAS DataBase List > L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)

L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)

Product Name
L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
CAS No.
220701-06-4
Chemical Name
L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
Synonyms
Fmoc-AENK-NH2;Fmoc-Ala-Glu-Asn-Lys-NH2;L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
CBNumber
CB58401114
Molecular Formula
C33H43N7O9
Formula Weight
681.75
MOL File
220701-06-4.mol
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L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) Property

Boiling point:
1151.3±65.0 °C(Predicted)
Density 
1.324±0.06 g/cm3(Predicted)
storage temp. 
-20°C, protect from light, stored under nitrogen
solubility 
DMSO: 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)
form 
Solid
pka
4.44±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0078435
Product name
Fmoc-Ala-Glu-Asn-Lys-NH2
Purity
98.04%
Packaging
5mg
Price
$135
Updated
2021/12/16
ChemScene
Product number
CS-0078435
Product name
Fmoc-Ala-Glu-Asn-Lys-NH2
Purity
98.04%
Packaging
10mg
Price
$235
Updated
2021/12/16
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L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) Chemical Properties,Usage,Production

Biological Activity

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1]. Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].

References

[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.

L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) Suppliers

Beijing Solarbio Science & Tecnology Co., Ltd.
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Chengdu Youngshe Chemical Co., Ltd.
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220701-06-4, L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)Related Search:


  • L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
  • Fmoc-Ala-Glu-Asn-Lys-NH2
  • Fmoc-AENK-NH2
  • 220701-06-4
  • C33H43N7O9