ChemicalBook > CAS DataBase List > L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
- Product Name
- L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
- CAS No.
- 220701-06-4
- Chemical Name
- L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
- Synonyms
- Fmoc-AENK-NH2;Fmoc-Ala-Glu-Asn-Lys-NH2;L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
- CBNumber
- CB58401114
- Molecular Formula
- C33H43N7O9
- Formula Weight
- 681.75
- MOL File
- 220701-06-4.mol
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L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) Property
- Boiling point:
- 1151.3±65.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light, stored under nitrogen
- solubility
- DMSO: 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)
- form
- Solid
- pka
- 4.44±0.10(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0078435
- Product name
- Fmoc-Ala-Glu-Asn-Lys-NH2
- Purity
- 98.04%
- Packaging
- 5mg
- Price
- $135
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0078435
- Product name
- Fmoc-Ala-Glu-Asn-Lys-NH2
- Purity
- 98.04%
- Packaging
- 10mg
- Price
- $235
- Updated
- 2021/12/16
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L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) Chemical Properties,Usage,Production
Uses
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].
Biological Activity
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1]. Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].
References
[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.
L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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